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Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

Fiolet, Thibault ; Casagrande, Corinne ; Nicolas, Geneviève ; Horvath, Zsuzsanna ; Frenoy, Pauline ; Weiderpass, Elisabete ; Katzke, Verena ; Kaaks, Rudolf ; Rodriguez-Barranco, Miguel and Panico, Salvatore , et al. (2022) In Environment International 163.
Abstract

Background: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure. Methods: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5–16.4).... (More)

Background: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure. Methods: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5–16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority. Results: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors. Conclusions: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.

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type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, Diet, Dioxins, PCBs, Persistent pollutants, Polychlorobiphenyls
in
Environment International
volume
163
article number
107213
publisher
Elsevier
external identifiers
  • scopus:85127167792
  • pmid:35364416
ISSN
0160-4120
DOI
10.1016/j.envint.2022.107213
language
English
LU publication?
yes
id
aba17169-6edf-46f1-8df6-a1d7ce315621
date added to LUP
2022-06-14 14:59:51
date last changed
2022-07-27 22:11:42
@article{aba17169-6edf-46f1-8df6-a1d7ce315621,
  abstract     = {{<p>Background: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure. Methods: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5–16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority. Results: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HR<sub>dioxins</sub> = 1.00 (0.98 to 1.02), HR<sub>dioxins+DL-PCB</sub> = 1.01 (0.98 to 1.03), HR<sub>DL-PCB</sub> = 1.01 (0.98 to 1.03), and HR<sub>NDL-PCB</sub> = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors. Conclusions: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.</p>}},
  author       = {{Fiolet, Thibault and Casagrande, Corinne and Nicolas, Geneviève and Horvath, Zsuzsanna and Frenoy, Pauline and Weiderpass, Elisabete and Katzke, Verena and Kaaks, Rudolf and Rodriguez-Barranco, Miguel and Panico, Salvatore and Sacerdote, Carlotta and Manjer, Jonas and Sonestedt, Emily and Grioni, Sara and Agudo, Antonio and Rylander, Charlotta and Haugdahl Nøst, Therese and Skeie, Guri and Tjønneland, Anne and Raaschou-Nielsen, Ole and Ardanaz, Eva and Amiano, Pilar and Dolores Chirlaque López, María and Schulze, Matthias B. and Wennberg, Maria and Harlid, Sophia and Cairat, Manon and Kvaskoff, Marina and Huybrechts, Inge and Romana Mancini, Francesca}},
  issn         = {{0160-4120}},
  keywords     = {{Breast cancer; Diet; Dioxins; PCBs; Persistent pollutants; Polychlorobiphenyls}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Environment International}},
  title        = {{Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries}},
  url          = {{http://dx.doi.org/10.1016/j.envint.2022.107213}},
  doi          = {{10.1016/j.envint.2022.107213}},
  volume       = {{163}},
  year         = {{2022}},
}