Advanced

Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition

Perez-Cornago, Aurora ; Huybrechts, Inge ; Appleby, Paul N. ; Schmidt, Julie A. ; Crowe, Francesca L. ; Overvad, Kim ; Tjønneland, Anne ; Kühn, Tilman ; Katzke, Verena and Trichopoulou, Antonia , et al. (2020) In International Journal of Cancer 146(1). p.44-57
Abstract


The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).... (More)


The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (p
heterogeneity
< 0.015), with a positive association with risk of advanced stage disease for butyric acid (4:0; HR
1SD
= 1.08; 95%CI = 1.01–1.15; p-trend = 0.026). There were no associations with fatal prostate cancer, with the exception of a slightly higher risk for those who consumed more eicosenoic acid (22:1n-9c; HR
1SD
= 1.05; 1.00–1.11; p-trend = 0.048) and eicosapentaenoic acid (20:5n-3c; HR
1SD
= 1.07; 1.00–1.14; p-trend = 0.045). There was no evidence that dietary intakes of individual fatty acids were associated with overall prostate cancer risk. However, a higher intake of butyric acid might be associated with a higher risk of advanced, whereas intakes of eicosenoic and eicosapentaenoic acids might be positively associated with fatal prostate cancer risk.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
individual fatty acids, prospective, prostate cancer, tumor subtypes
in
International Journal of Cancer
volume
146
issue
1
pages
44 - 57
publisher
John Wiley and Sons Inc.
external identifiers
  • scopus:85062988761
  • pmid:30807653
ISSN
0020-7136
DOI
10.1002/ijc.32233
language
English
LU publication?
yes
id
c7cc5554-25f3-4904-8e2e-3adb186b8884
date added to LUP
2019-03-29 14:40:07
date last changed
2020-04-27 10:01:19
@article{c7cc5554-25f3-4904-8e2e-3adb186b8884,
  abstract     = {<p><br>
                                                         The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (p                             <br>
                            <sub>heterogeneity</sub><br>
                                                          &lt; 0.015), with a positive association with risk of advanced stage disease for butyric acid (4:0; HR                             <br>
                            <sub>1SD</sub><br>
                                                          = 1.08; 95%CI = 1.01–1.15; p-trend = 0.026). There were no associations with fatal prostate cancer, with the exception of a slightly higher risk for those who consumed more eicosenoic acid (22:1n-9c; HR                             <br>
                            <sub>1SD</sub><br>
                                                          = 1.05; 1.00–1.11; p-trend = 0.048) and eicosapentaenoic acid (20:5n-3c; HR                             <br>
                            <sub>1SD</sub><br>
                                                          = 1.07; 1.00–1.14; p-trend = 0.045). There was no evidence that dietary intakes of individual fatty acids were associated with overall prostate cancer risk. However, a higher intake of butyric acid might be associated with a higher risk of advanced, whereas intakes of eicosenoic and eicosapentaenoic acids might be positively associated with fatal prostate cancer risk.                         <br>
                        </p>},
  author       = {Perez-Cornago, Aurora and Huybrechts, Inge and Appleby, Paul N. and Schmidt, Julie A. and Crowe, Francesca L. and Overvad, Kim and Tjønneland, Anne and Kühn, Tilman and Katzke, Verena and Trichopoulou, Antonia and Karakatsani, Anna and Peppa, Eleni and Grioni, Sara and Palli, Domenico and Sacerdote, Carlotta and Tumino, Rosario and Bueno-de-Mesquita, H. Bas and Larrañaga, Nerea and Sánchez, Maria Jose and Quirós, J. Ramón and Ardanaz, Eva and Chirlaque, María Dolores and Agudo, Antonio and Bjartell, Anders and Wallström, Peter and Chajes, Veronique and Tsilidis, Konstantinos K. and Aune, Dagfinn and Riboli, Elio and Travis, Ruth C. and Key, Timothy J.},
  issn         = {0020-7136},
  language     = {eng},
  number       = {1},
  pages        = {44--57},
  publisher    = {John Wiley and Sons Inc.},
  series       = {International Journal of Cancer},
  title        = {Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.32233},
  doi          = {10.1002/ijc.32233},
  volume       = {146},
  year         = {2020},
}