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2021
Mark Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling, Daniel ; Zhang, Si Min ; Jemth, Ann-Sofie ; Koolmeister, Tobias ; Throup, Adam ; Wallner, Olov ; Scaletti, Emma ^LU ; Moriyama, Takaya ; Nishii, Rina and Davies, Jonathan , et al. (2021) In The Journal of biological chemistry 296.
- Contribution to journal › Article
Mark NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang, Si Min ; Rehling, Daniel ; Jemth, Ann-Sofie ; Throup, Adam ; Landázuri, Natalia ; Almlöf, Ingrid ; Göttmann, Mona ; Valerie, Nicholas C K ; Borhade, Sanjay R and Wakchaure, Prasad , et al. (2021) In Cell Chemical Biology 28(12). p.6-1702
- Contribution to journal › Article
2020
Mark Development of a chemical probe against NUDT15
Zhang, Si Min ; Desroses, Matthieu ; Hagenkort, Anna ; Valerie, Nicholas C K ; Rehling, Daniel ; Carter, Megan ; Wallner, Olov ; Koolmeister, Tobias ; Throup, Adam and Jemth, Ann-Sofie , et al. (2020) In Nature Chemical Biology 16(10). p.1120-1128
- Contribution to journal › Article
2018
Mark Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter, Megan ; Jemth, Ann-Sofie ; Carreras-Puigvert, Jordi ; Herr, Patrick ; Martínez Carranza, Markel ; Vallin, Karl S A ; Throup, Adam ; Helleday, Thomas and Stenmark, Pål ^LU (2018) In Structure 26(2). p.6-303
- Contribution to journal › Article
2017
Mark Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction
Llona-Minguez, Sabin ; Throup, Adam ; Steiner, Emilie ; Lightowler, Molly ; Van der Haegen, Sandra ; Homan, Evert ; Eriksson, Lars ; Stenmark, Pål ^LU ; Jenmalm-Jensen, Annika and Helleday, Thomas (2017) In Organic and Biomolecular Chemistry 15(37). p.7758-7764
- Contribution to journal › Article