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- 2019
- Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
- Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
- 2018
- The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
- Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
- Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
- Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
- Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
- Different angioregulatory activity of monovalent galectin-9 isoforms
- Designing interactions by control of protein-ligand complex conformation : Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
- Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function
- Galectins at a glance
- Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions
- 2017
- Spindle pole cohesion requires glycosylation-mediated localization of NuMA
- Galectin-3 inhibition by a small-molecule inhibitor reduces both pathological corneal neovascularization and fibrosis
- 2016
- Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans
- Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C
- Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
- Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition
- Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.
- Intra- and inter-molecular interactions of human galectin-3: assessment by full-assignment-based NMR.
- Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3 '-sulfo-lactose, and 2 '-fucosyllactose
- Galactose-amidine derivatives as selective antagonists of galectin-9
- A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model
- 2015
- Structural characterisation of human galectin-4 C-terminal domain -elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens.
- Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury
- Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
- 2014
- Primary and secondary glomerulonephritides 1.
- Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins
- Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists.
- 2013
- Galectin-3 guides intracellular trafficking of some human serotransferrin glycoforms
- Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro
- Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors
- Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1
- 2012
- Taloside inhibitors of Galectin-1 and Galectin-3.
- Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.
- The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
- Ligand induced galectin-3 self-association.
- Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3
- Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins.
- Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy subjects.
- Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual
- Low-Molecular Weight Inhibitors of Galectins
- Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease.
- 2011
- Arene-Anion Based Arginine-Binding Motif on a Galactose Scaffold: Structure-Activity Relationships of Interactions with Arginine-Rich Galectins.
- Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.
- Inhibition of Galectins with Small Molecules
- The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.
- Synthesis of 3-amido-3-deoxy-beta-D-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors
- 2010
- 1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors
- Copper-Free Huisgen 1,3-Dipolar Cycloaddition to 3-Benzotriazolo-3-Deoxy-β-D-Galactopyranosides – Cyclization of a Secondary Azide and Benzyne