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- 2024
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Mark
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
2024) In Journal of Medicinal Chemistry(
- Contribution to journal › Article
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Mark
Interplay of halogen bonding and solvation in protein-ligand binding
(
- Contribution to journal › Article
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Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket
(
- Contribution to journal › Article
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Mark
Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
(
- Contribution to journal › Article
- 2023
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Mark
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
(
- Contribution to journal › Article
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Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
(
- Contribution to journal › Article
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Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
(
- Contribution to journal › Article
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Mark
Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds
(
- Contribution to journal › Article
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Mark
Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
(
- Contribution to journal › Article
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Mark
Discovery of Selective and Orally Available Galectin-1 Inhibitors
(
- Contribution to journal › Article
- 2022
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Mark
Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside
(
- Contribution to journal › Article
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Mark
Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
(
- Contribution to journal › Article
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Mark
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia
(
- Contribution to journal › Article
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Mark
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors
(
- Contribution to journal › Article
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Mark
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
(
- Contribution to journal › Article
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Mark
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix
(
- Contribution to journal › Article
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Mark
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
(
- Contribution to journal › Article
- 2021
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Mark
Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C
(
- Contribution to journal › Article
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Mark
Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors
(
- Contribution to journal › Article
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Mark
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression
(
- Contribution to journal › Article
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Mark
Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals
(
- Contribution to journal › Article
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Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain : Structure-based design and optimisation
(
- Contribution to journal › Article
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Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
(
- Contribution to journal › Article
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Structure-Guided Design of d -Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain
(
- Contribution to journal › Article
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Mark
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
(
- Contribution to journal › Article
- 2020
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Mark
Epimers Switch Galectin-9 Domain Selectivity : 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal
(
- Contribution to journal › Article
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Mark
In Vivo Veritas : 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
(
- Contribution to journal › Article
- 2019
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Mark
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors
(
- Contribution to journal › Article
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Mark
Extracellular and intracellular small-molecule galectin-3 inhibitors
(
- Contribution to journal › Article
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Mark
Human trophoblast requires galectin-3 for cell migration and invasion
(
- Contribution to journal › Article
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Mark
An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade
(
- Contribution to journal › Article
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Mark
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
(
- Contribution to journal › Article
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Mark
C1-Galactopyranosyl Heterocycle Structure Guides Selectivity : Triazoles Prefer Galectin-1 and Oxazoles Prefer Galectin-3
(
- Contribution to journal › Article
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Mark
Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
(
- Contribution to journal › Article
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Mark
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
(
- Contribution to journal › Article
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Mark
Stereo- And regioselective hydroboration of 1-exo-methylene pyranoses : Discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors
(
- Contribution to journal › Article
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Mark
A galactoside-binding protein tricked into binding unnatural pyranose derivatives : 3-deoxy-3-methyl-gulosides selectively inhibit galectin-1
(
- Contribution to journal › Article
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Mark
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
(
- Contribution to journal › Article
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Mark
Structure and Energetics of Ligand–Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides : Insight into Solvation Effects and Multipolar Interactions
(
- Contribution to journal › Article
- 2018
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Mark
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
(
- Contribution to journal › Article
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Mark
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
(
- Contribution to journal › Article
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Mark
Designing interactions by control of protein-ligand complex conformation : Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
(
- Contribution to journal › Article
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Mark
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
(
- Contribution to journal › Article
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Mark
Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function
(
- Contribution to journal › Article
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Mark
Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions
(
- Contribution to journal › Article
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Mark
Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
(
- Contribution to journal › Article
- 2017
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Mark
Galectin-3 inhibition by a small-molecule inhibitor reduces both pathological corneal neovascularization and fibrosis
(
- Contribution to journal › Article
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Mark
Spindle pole cohesion requires glycosylation-mediated localization of NuMA
(
- Contribution to journal › Article
- 2016
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Mark
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3 '-sulfo-lactose, and 2 '-fucosyllactose
(
- Contribution to journal › Article
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Mark
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
(
- Contribution to journal › Article