Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.
(2014) In Diabetes 63(5). p.1665-1671- Abstract
- The most frequently used, and effective, treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB), which results in rapid remission of T2D in most cases. To what extent this is accounted for by weight loss or other factors remains elusive. To gain insight into these mechanisms, we investigated the effects of RYGB on ß-cell function and ß-cell mass in the pig, a species highly reminiscent of the human. RYGB was performed using linear staplers during open surgery. Sham-operated pigs were used as controls. Both groups were fed a low calorie diet for 3 weeks after surgery. Intravenous glucose-tolerance tests were performed 2 weeks after surgery. Body weight in RYGB-pigs and sham-operated, pair-fed control pigs developed... (More)
- The most frequently used, and effective, treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB), which results in rapid remission of T2D in most cases. To what extent this is accounted for by weight loss or other factors remains elusive. To gain insight into these mechanisms, we investigated the effects of RYGB on ß-cell function and ß-cell mass in the pig, a species highly reminiscent of the human. RYGB was performed using linear staplers during open surgery. Sham-operated pigs were used as controls. Both groups were fed a low calorie diet for 3 weeks after surgery. Intravenous glucose-tolerance tests were performed 2 weeks after surgery. Body weight in RYGB-pigs and sham-operated, pair-fed control pigs developed similarly. RYGB-pigs displayed improved glycaemic control, which was attributed to increases in ß-cell mass, islet number and number of extra-islet ß-cells. Pancreatic expression of insulin and glucagon was elevated, and cells expressing the GLP-1-receptor were more abundant in RYGB-pigs. Our data from a pig model of RYGB emphasize the key role of improved ß-cell function and ß-cell mass to explain the improved glucose tolerance after RYGB as food intake and body weight remained identical. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4335894
- author
- Lindqvist, Andreas LU ; Spégel, Peter LU ; Ekelund, Mikael LU ; Garcia Vaz, Eliana LU ; Pierzynowski, Stefan ; Gomez, Maria LU ; Mulder, Hindrik LU ; Hedenbro, Jan LU ; Groop, Leif LU and Wierup, Nils LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 63
- issue
- 5
- pages
- 1665 - 1671
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- pmid:24487021
- wos:000334796600029
- scopus:84899126845
- ISSN
- 1939-327X
- DOI
- 10.2337/db13-0969
- language
- English
- LU publication?
- yes
- id
- b1d2d5da-8519-404f-8b02-150fb1a4e95d (old id 4335894)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24487021?dopt=Abstract
- date added to LUP
- 2016-04-01 09:50:46
- date last changed
- 2024-04-20 21:27:03
@article{b1d2d5da-8519-404f-8b02-150fb1a4e95d, abstract = {{The most frequently used, and effective, treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB), which results in rapid remission of T2D in most cases. To what extent this is accounted for by weight loss or other factors remains elusive. To gain insight into these mechanisms, we investigated the effects of RYGB on ß-cell function and ß-cell mass in the pig, a species highly reminiscent of the human. RYGB was performed using linear staplers during open surgery. Sham-operated pigs were used as controls. Both groups were fed a low calorie diet for 3 weeks after surgery. Intravenous glucose-tolerance tests were performed 2 weeks after surgery. Body weight in RYGB-pigs and sham-operated, pair-fed control pigs developed similarly. RYGB-pigs displayed improved glycaemic control, which was attributed to increases in ß-cell mass, islet number and number of extra-islet ß-cells. Pancreatic expression of insulin and glucagon was elevated, and cells expressing the GLP-1-receptor were more abundant in RYGB-pigs. Our data from a pig model of RYGB emphasize the key role of improved ß-cell function and ß-cell mass to explain the improved glucose tolerance after RYGB as food intake and body weight remained identical.}}, author = {{Lindqvist, Andreas and Spégel, Peter and Ekelund, Mikael and Garcia Vaz, Eliana and Pierzynowski, Stefan and Gomez, Maria and Mulder, Hindrik and Hedenbro, Jan and Groop, Leif and Wierup, Nils}}, issn = {{1939-327X}}, language = {{eng}}, number = {{5}}, pages = {{1665--1671}}, publisher = {{American Diabetes Association Inc.}}, series = {{Diabetes}}, title = {{Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.}}, url = {{https://lup.lub.lu.se/search/files/1312413/4647201.pdf}}, doi = {{10.2337/db13-0969}}, volume = {{63}}, year = {{2014}}, }