Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations : The EPIC-InterAct Study

Ibsen, Daniel B ; Steur, Marinka ; Imamura, Fumiaki ; Overvad, Kim ; Schulze, Matthias B ; Bendinelli, Benedetta ; Guevara, Marcela ; Agudo, Antonio ; Amiano, Pilar and Aune, Dagfinn , et al. (2020) In Diabetes Care 43(11). p.2660-2667
Abstract

OBJECTIVE: There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact.

RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer (EPIC)-InterAct case cohort included 11,741 individuals with type 2 diabetes and a subcohort of 15,450 participants in eight countries. We modeled the replacement of self-reported red and processed meat with poultry, fish, eggs, legumes, cheese, cereals, yogurt, milk, and nuts. Country-specific hazard ratios (HRs) for incident type 2 diabetes were... (More)

OBJECTIVE: There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact.

RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer (EPIC)-InterAct case cohort included 11,741 individuals with type 2 diabetes and a subcohort of 15,450 participants in eight countries. We modeled the replacement of self-reported red and processed meat with poultry, fish, eggs, legumes, cheese, cereals, yogurt, milk, and nuts. Country-specific hazard ratios (HRs) for incident type 2 diabetes were estimated by Prentice-weighted Cox regression and pooled using random-effects meta-analysis.

RESULTS: There was a lower hazard for type 2 diabetes for the modeled replacement of red and processed meat `(50 g/day) with cheese (HR 0.90, 95% CI 0.83-0.97) (30 g/day), yogurt (0.90, 0.86-0.95) (70 g/day), nuts (0.90, 0.84-0.96) (10 g/day), or cereals (0.92, 0.88-0.96) (30 g/day) but not for replacements with poultry, fish, eggs, legumes, or milk. If a causal association is assumed, replacing red and processed meat with cheese, yogurt, or nuts could prevent 8.8%, 8.3%, or 7.5%, respectively, of new cases of type 2 diabetes.

CONCLUSIONS: Replacement of red and processed meat with cheese, yogurt, nuts, or cereals was associated with a lower rate of type 2 diabetes. Substituting red and processed meat by other protein sources may contribute to the prevention of incident type 2 diabetes in European populations.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
43
issue
11
pages
2660 - 2667
publisher
American Diabetes Association
external identifiers
  • scopus:85093862635
  • pmid:32868270
ISSN
1935-5548
DOI
10.2337/dc20-1038
language
English
LU publication?
yes
additional info
© 2020 by the American Diabetes Association.
id
97a75644-be60-4646-9acb-cb057bf24afb
date added to LUP
2020-09-02 20:27:47
date last changed
2024-04-17 14:49:39
@article{97a75644-be60-4646-9acb-cb057bf24afb,
  abstract     = {{<p>OBJECTIVE: There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact.</p><p>RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer (EPIC)-InterAct case cohort included 11,741 individuals with type 2 diabetes and a subcohort of 15,450 participants in eight countries. We modeled the replacement of self-reported red and processed meat with poultry, fish, eggs, legumes, cheese, cereals, yogurt, milk, and nuts. Country-specific hazard ratios (HRs) for incident type 2 diabetes were estimated by Prentice-weighted Cox regression and pooled using random-effects meta-analysis.</p><p>RESULTS: There was a lower hazard for type 2 diabetes for the modeled replacement of red and processed meat `(50 g/day) with cheese (HR 0.90, 95% CI 0.83-0.97) (30 g/day), yogurt (0.90, 0.86-0.95) (70 g/day), nuts (0.90, 0.84-0.96) (10 g/day), or cereals (0.92, 0.88-0.96) (30 g/day) but not for replacements with poultry, fish, eggs, legumes, or milk. If a causal association is assumed, replacing red and processed meat with cheese, yogurt, or nuts could prevent 8.8%, 8.3%, or 7.5%, respectively, of new cases of type 2 diabetes.</p><p>CONCLUSIONS: Replacement of red and processed meat with cheese, yogurt, nuts, or cereals was associated with a lower rate of type 2 diabetes. Substituting red and processed meat by other protein sources may contribute to the prevention of incident type 2 diabetes in European populations.</p>}},
  author       = {{Ibsen, Daniel B and Steur, Marinka and Imamura, Fumiaki and Overvad, Kim and Schulze, Matthias B and Bendinelli, Benedetta and Guevara, Marcela and Agudo, Antonio and Amiano, Pilar and Aune, Dagfinn and Barricarte, Aurelio and Ericson, Ulrika and Fagherazzi, Guy and Franks, Paul W and Freisling, Heinz and Quiros, Jose R and Grioni, Sara and Heath, Alicia K and Huybrechts, Inge and Katze, Verena and Laouali, Nasser and Mancini, Francesca and Masala, Giovanna and Olsen, Anja and Papier, Keren and Ramne, Stina and Rolandsson, Olov and Sacerdote, Carlotta and Sánchez, Maria-José and Santiuste, Carmen and Simeon, Vittorio and Spijkerman, Annemieke M W and Srour, Bernard and Tjønneland, Anne and Tong, Tammy Y N and Tumino, Rosario and van der Schouw, Yvonne T and Weiderpass, Elisabete and Wittenbecher, Clemens and Sharp, Stephen J and Riboli, Elio and Forouhi, Nita G and Wareham, Nick J}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2660--2667}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations : The EPIC-InterAct Study}},
  url          = {{http://dx.doi.org/10.2337/dc20-1038}},
  doi          = {{10.2337/dc20-1038}},
  volume       = {{43}},
  year         = {{2020}},
}