Diabetes - Islet Cell Exocytosis
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- 2015
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Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents
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- Contribution to journal › Article
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MiR-184 regulates pancreatic β-cell function according to glucose metabolism.
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- Contribution to journal › Article
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MiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells
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- Contribution to journal › Published meeting abstract
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Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
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- Thesis › Doctoral thesis (compilation)
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Type 2 diabetes mellitus
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- Contribution to journal › Article
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Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
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- Contribution to journal › Article
- 2014
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MicroRNA-7a regulates pancreatic beta cell function
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- Contribution to journal › Article
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Calcium Current Inactivation Rather than Pool Depletion Explains Reduced Exocytotic Rate with Prolonged Stimulation in Insulin-Secreting INS-1 832/13 Cells.
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- Contribution to journal › Article
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Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
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- Contribution to journal › Article
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Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2.
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- Contribution to journal › Article
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
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- Contribution to journal › Article
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Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.
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- Contribution to journal › Article
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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.
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- Contribution to journal › Article
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Nova1 is a master regulator of alternative splicing in pancreatic beta cells.
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- Contribution to journal › Article
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The exocytotic machinery.
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- Contribution to journal › Article
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Impaired Fibrous Repair: A Possible Contributor to Atherosclerotic Plaque Vulnerability in Patients With Type II Diabetes.
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- Contribution to journal › Article
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Role of non-coding RNAs in pancreatic beta-cell development and physiology.
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- Contribution to journal › Scientific review
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Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell.
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- Contribution to journal › Article
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Melatonin heals the gut
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- Contribution to journal › Debate/Note/Editorial
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Dynamic Magnetic Fields Remote-Control Apoptosis via Nanoparticle Rotation.
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- Contribution to journal › Article
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CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
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- Contribution to journal › Article
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Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
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- Contribution to journal › Scientific review
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Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans.
(
- Contribution to journal › Scientific review
- 2013
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Effects of mating system on adaptive potential for leaf morphology in Crepis tectorum (Asteraceae).
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- Contribution to journal › Article
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Progesterone metabolite influence feeding behaviour.
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- Contribution to journal › Debate/Note/Editorial
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Fast Surface Acoustic Wave-Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Cell Response from Islets of Langerhans.
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- Contribution to journal › Article
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New drug for treatment of insulin-resistant complication?
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- Contribution to journal › Letter
- 2012
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Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
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- Thesis › Doctoral thesis (compilation)
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Mark
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
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- Contribution to journal › Article
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Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
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- Contribution to journal › Article
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Synapsins I and II Are Not Required for Insulin Secretion from Mouse Pancreatic beta-cells
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- Contribution to journal › Article
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Multivesicular exocytosis in rat pancreatic beta cells
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- Contribution to journal › Article
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Reduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
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- Contribution to journal › Article
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CD46 costimulation leads to enhanced T cell activation and microrna expression
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- Contribution to journal › Published meeting abstract
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A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
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- Contribution to journal › Article
- 2011
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Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell.
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- Contribution to journal › Article
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Multiscale Modeling of Insulin Secretion
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- Contribution to journal › Article
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Electrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans
(
- Contribution to journal › Scientific review
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Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in beta-cells from mice and humans.
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- Contribution to journal › Article
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On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls.
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- Contribution to journal › Article
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Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.
(
- Contribution to journal › Article
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Mark
Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects.
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- Contribution to journal › Article
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Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
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- Contribution to journal › Article
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Beta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus.
(
- Contribution to journal › Article
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Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates
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- Contribution to journal › Article
- 2010
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Mark
Regulation of glucagon secretion from pancreatic alpha cells
(
- Thesis › Doctoral thesis (compilation)
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Mark
Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.
(
- Contribution to journal › Article
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Mark
MicroRNA differences in human islets and glucose-sensitive tissues
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.527-527(
- Contribution to journal › Published meeting abstract
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Mark
Active CFTR channels are important for insulin- and glucagon secretion
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.557-557(
- Contribution to journal › Published meeting abstract
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Mark
Pharmacological effects on insulin release in a mathematical model of human beta cells
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53. p.552-552(
- Contribution to journal › Published meeting abstract
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Mark
A Biophysical Model of Electrical Activity in Human β-Cells.
(
- Contribution to journal › Article
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GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
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- Contribution to journal › Article
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Secretion and Dipeptidyl Peptidase-4-Mediated Metabolism of Incretin Hormones after a Mixed Meal or Glucose Ingestion in Obese Compared to Lean, Nondiabetic Men.
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- Contribution to journal › Article
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Insulin Secretory Granules Enter a Highly Calcium-Sensitive State following Palmitate-Induced Dissociation from Calcium Channels: A Theoretical Study
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- Contribution to journal › Article
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Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
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- Contribution to journal › Article
- 2009
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Both rapid exocytosis and granule mobilization in glucagon secreting cells are reduced by antibodies against synaptosomal protein of 25 kDa (SNAP-25) and Syntaxin 1
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.442-442(
- Contribution to journal › Published meeting abstract
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Mark
Rapid changes in surface expression of L-type Cav1.2 channels in stimulated INS-1 cells
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl. 1). p.436-436(
- Contribution to journal › Published meeting abstract
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Mark
Deletion of the G protein-coupled Receptor GPR30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-stimulated Insulin Release in Female Mice.
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- Contribution to journal › Article
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Mark
Evidence for PKA-independent priming of insulin secretory granules: insight from mathematical modeling
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.443-443(
- Contribution to journal › Published meeting abstract
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Mark
Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.
(
- Contribution to journal › Article
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Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
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- Contribution to journal › Article
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Mark
Hyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.108-108(
- Contribution to journal › Published meeting abstract
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Mark
Dual effects of low and high concentrations of cAMP on glucagon secretion from mouse pancreatic A-cells
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.562-562(
- Contribution to journal › Published meeting abstract
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Mark
Differential Islet and Incretin Hormone Responses in Morning vs. Afternoon after Standardized Meal in Healthy Men.
(
- Contribution to journal › Article
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Predicted targets of co-expressed microRNAs in pancreatic islets of GK rats are enriched for genes involved in regulation of beta cell mass and glucose-stimulated insulin secretion
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.391-391(
- Contribution to journal › Published meeting abstract
- 2008
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Mark
Novel aspects of the molecular mechanisms controlling insulin secretion
(
- Contribution to journal › Scientific review
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Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans
2008) In Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Science 366(1880). p.3503-3523(
- Contribution to journal › Article
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Mark
Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.
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- Contribution to journal › Article
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CAPS1 and CAPS2 Regulate Stability and Recruitment of Insulin Granules in Mouse Pancreatic beta Cells.
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- Contribution to journal › Article
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GLP-1 inhibits glucagon secretion by affecting several cellular mechanisms
2008) 44th EASD Annual Meeting of the European Association for the Study of Diabetes In Diabetologia 51(S1). p.256-256(
- Contribution to journal › Published meeting abstract
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Mark
Exocytosis in insulin secreting cells - role of SNARE-proteins
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- Thesis › Doctoral thesis (compilation)
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Mark
Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon
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- Contribution to journal › Article
- 2007
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Mark
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells
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- Contribution to journal › Article
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Mark
A K-ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of langerhans
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- Contribution to journal › Article
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Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
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- Contribution to journal › Article
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Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: Evidence for the existence of insulinotropic agents in the stomach.
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- Contribution to journal › Article
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beta-cell PDE3B regulates Ca(2+)-stimulated exocytosis of insulin.
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- Contribution to journal › Article
- 2006
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Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.
(
- Contribution to journal › Article
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Mark
Intra-islet insulin suppresses glucagon release via GABA-GABA(A) receptor system
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- Contribution to journal › Article
- 2005
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Mark
Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat {beta}-Cells.
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- Contribution to journal › Article
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Mark
Glucagon stimulates exocytosis in mouse and rat pancreatic {alpha} cells by binding to glucagon receptors.
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- Contribution to journal › Article
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Adenovirus-mediated silencing of Synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets
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- Contribution to journal › Article
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Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
(
- Contribution to journal › Article
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Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca(2+) channels.
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- Contribution to journal › Article
- 2004
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Mark
GABAB-receptor activation inhibits exocytosis in rat pancreatic {beta}-cells by G-protein-dependent activation of calcineurin.
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- Contribution to journal › Article
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Capacitance measurements of exocytosis in mouse pancreatic {alpha}-, {beta}- and {delta}-cells studied in intact islets of Langerhans.
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- Contribution to journal › Article
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Mark
Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic {beta}-cells.
(
- Contribution to journal › Article
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Glucose Inhibition of Glucagon Secretion From Rat alpha-Cells Is Mediated by GABA Released From Neighboring beta-Cells.
(
- Contribution to journal › Article
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The first gamma-carboxyglutamic acid-containing contryphan - A selective L-type calcium ion channel blocker isolated from the venom of conus marmoreus
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- Contribution to journal › Article
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Mark
GABA in the islets of Langerhans
2004)(
- Thesis › Doctoral thesis (compilation)
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Mark
A pancreatic islet-specific microRNA regulates insulin secretion
(
- Contribution to journal › Article
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Mark
Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements
(
- Contribution to journal › Article
- 2003
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Mark
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(V)1.2 Ca(2+) channel null mice.
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- Contribution to journal › Article
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Mark
SUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells.
(
- Contribution to journal › Article
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Requirement for N-ethylmaleimide-sensitive factor for exocytosis of insulin-containing secretory granules in pancreatic beta-cells.
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- Contribution to journal › Article
- 2002
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Mark
A Subset of 50 Secretory Granules in Close Contact With L-Type Ca(2+) Channels Accounts for First-Phase Insulin Secretion in Mouse beta-Cells.
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- Contribution to journal › Article
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Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
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- Contribution to journal › Article
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Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells.
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- Contribution to journal › Article
- 2001
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Mark
Gastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels
(
- Contribution to journal › Article
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Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification
(
- Contribution to journal › Article