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Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers : a multinational cohort study

Mayén, Ana-Lucia ; Aglago, Elom K ; Knaze, Viktoria ; Cordova, Reynalda ; Schalkwijk, Casper G ; Wagner, Karl-Heinz ; Aleksandrova, Krasimira ; Fedirko, Veronika ; Keski-Rahkonen, Pekka and Leitzmann, Michael F , et al. (2021) In International Journal of Cancer 149(4). p.854-864
Abstract

Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL), and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95%... (More)

Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL), and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder, and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer, and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with risk of HCC (per 1 standard deviation [SD] increment, HR-CML =0.87, 95% CI: 0.76 to 0.99, HR-CEL =0.84, 95% CI: 0.74 to 0.96, and HR-MH-G1 = 0.84, 95% CI: 0.74 to 0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML =1.28, 95% CI: 1.05 to 1.56, HR-CEL =1.17; 95% CI: 0.96 to 1.40, HR-MH-G1 =1.27, 95% CI: 1.06 to 1.54). No associations were observed for cancers of the intra- and extra-hepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
149
issue
4
pages
11 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:33899229
  • scopus:85105630736
ISSN
0020-7136
DOI
10.1002/ijc.33612
language
English
LU publication?
yes
id
0032fda5-bcaa-43c6-b56c-06f17af09aac
date added to LUP
2021-05-01 19:05:08
date last changed
2024-06-15 10:39:11
@article{0032fda5-bcaa-43c6-b56c-06f17af09aac,
  abstract     = {{<p>Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL), and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder, and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer, and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with risk of HCC (per 1 standard deviation [SD] increment, HR-CML =0.87, 95% CI: 0.76 to 0.99, HR-CEL =0.84, 95% CI: 0.74 to 0.96, and HR-MH-G1 = 0.84, 95% CI: 0.74 to 0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML =1.28, 95% CI: 1.05 to 1.56, HR-CEL =1.17; 95% CI: 0.96 to 1.40, HR-MH-G1 =1.27, 95% CI: 1.06 to 1.54). No associations were observed for cancers of the intra- and extra-hepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.</p>}},
  author       = {{Mayén, Ana-Lucia and Aglago, Elom K and Knaze, Viktoria and Cordova, Reynalda and Schalkwijk, Casper G and Wagner, Karl-Heinz and Aleksandrova, Krasimira and Fedirko, Veronika and Keski-Rahkonen, Pekka and Leitzmann, Michael F and Katzke, Verena and Srour, Bernard and Schulze, Matthias B and Masala, Giovanna and Krogh, Vittorio and Panico, Salvatore and Tumino, Rosario and Bueno-de-Mesquita, Bas and Brustad, Magritt and Agudo, Antonio and Chirlaque López, María Dolores and Amiano, Pilar and Ohlsson, Bodil and Ramne, Stina and Aune, Dagfinn and Weiderpass, Elisabete and Jenab, Mazda and Freisling, Heinz}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{4}},
  pages        = {{854--864}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers : a multinational cohort study}},
  url          = {{http://dx.doi.org/10.1002/ijc.33612}},
  doi          = {{10.1002/ijc.33612}},
  volume       = {{149}},
  year         = {{2021}},
}