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Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition

Saadatian-Elahi, Mitra; Slimani, Nadia; Chajes, Veronique; Jenab, Mazda; Goudable, Joelle; Biessy, Carine; Ferrari, Pietro; Byrnes, Graham; Autier, Philippe and Peeters, Petra H. M., et al. (2009) In American Journal of Clinical Nutrition 89(1). p.331-346
Abstract
Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study. Design: A cross-sectional study design nested to the European Prospective Investigation into Cancer and Nutrition (EPIC) was conducted to determine plasma fatty acid profiles in > 3000 subjects from 16 centers, who had also completed 24-h dietary recalls and dietary questionnaires. Plasma fatty acids were assessed by capillary gas... (More)
Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study. Design: A cross-sectional study design nested to the European Prospective Investigation into Cancer and Nutrition (EPIC) was conducted to determine plasma fatty acid profiles in > 3000 subjects from 16 centers, who had also completed 24-h dietary recalls and dietary questionnaires. Plasma fatty acids were assessed by capillary gas chromatography. Ecological and individual correlations were calculated between fatty acids and select food groups. Results: The most important determinant of plasma fatty acids was region, which suggests that the variations across regions are largely due to different food intakes. Strong ecological correlations were observed between fish intake and long-chain n-3 polyunsaturated fatty acids (r = 0.78, P < 0.01), olive oil and oleic acid (r = 0.73, P < 0.01), and margarine and elaidic acid (r = 0.76, P < 0.01). Individual correlations varied across the regions, particularly between olive oil and oleic acid and between alcohol and the saturation index, as an indicator of stearoyl CoA desaturase activity. Conclusions: These findings indicate that specific plasma phospholipid fatty acids are suitable biomarkers of some food intakes in the EPIC Study. Moreover, these findings suggest complex interactions between alcohol intake and fatty acid metabolism, which warrants further attention in epidemiologic studies relating dietary fatty acids to alcohol-related cancers and other chronic diseases. Am J Clin Nutr 2009; 89: 331-46. (Less)
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American Journal of Clinical Nutrition
volume
89
issue
1
pages
331 - 346
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000262262300043
  • scopus:58149379940
ISSN
1938-3207
DOI
10.3945/ajcn.2008.26834
language
English
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yes
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568a5f4e-bd74-4cf1-a187-7d4558d0627e (old id 1313495)
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2009-03-10 08:34:23
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2017-12-17 03:44:03
@article{568a5f4e-bd74-4cf1-a187-7d4558d0627e,
  abstract     = {Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study. Design: A cross-sectional study design nested to the European Prospective Investigation into Cancer and Nutrition (EPIC) was conducted to determine plasma fatty acid profiles in &gt; 3000 subjects from 16 centers, who had also completed 24-h dietary recalls and dietary questionnaires. Plasma fatty acids were assessed by capillary gas chromatography. Ecological and individual correlations were calculated between fatty acids and select food groups. Results: The most important determinant of plasma fatty acids was region, which suggests that the variations across regions are largely due to different food intakes. Strong ecological correlations were observed between fish intake and long-chain n-3 polyunsaturated fatty acids (r = 0.78, P &lt; 0.01), olive oil and oleic acid (r = 0.73, P &lt; 0.01), and margarine and elaidic acid (r = 0.76, P &lt; 0.01). Individual correlations varied across the regions, particularly between olive oil and oleic acid and between alcohol and the saturation index, as an indicator of stearoyl CoA desaturase activity. Conclusions: These findings indicate that specific plasma phospholipid fatty acids are suitable biomarkers of some food intakes in the EPIC Study. Moreover, these findings suggest complex interactions between alcohol intake and fatty acid metabolism, which warrants further attention in epidemiologic studies relating dietary fatty acids to alcohol-related cancers and other chronic diseases. Am J Clin Nutr 2009; 89: 331-46.},
  author       = {Saadatian-Elahi, Mitra and Slimani, Nadia and Chajes, Veronique and Jenab, Mazda and Goudable, Joelle and Biessy, Carine and Ferrari, Pietro and Byrnes, Graham and Autier, Philippe and Peeters, Petra H. M. and Ocke, Marga and de Mesquita, Bas Bueno and Johansson, Ingegerd and Hallmans, Goeran and Manjer, Jonas and Wirfält, Elisabet and Gonzalez, Carlos A. and Navarro, Carmen and Martinez, Carmen and Amiano, Pilar and Suaerz, Laudina Rodriguez and Ardanaz, Eva and Tjonneland, Anne and Halkjaer, Jytte and Overvad, Kim and Jakobsen, Marianne Uhre and Berrino, Franco and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Vineis, Paolo and de Magistris, Maria Santucci and Spencer, Elisabeth A. and Crowe, Francesca L. and Bingham, Sheila and Khaw, Kay-Tee and Linseisen, Jakob and Rohrmann, Sabine and Boeing, Heiner and Noethlings, Ute and Olsen, Karina Standahl and Skeie, Guri and Lund, Eiliv and Trichopoulou, Antonia and Oustoglou, Erifili and Clavel-Chapelon, Francoise and Riboli, Elio},
  issn         = {1938-3207},
  language     = {eng},
  number       = {1},
  pages        = {331--346},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.3945/ajcn.2008.26834},
  volume       = {89},
  year         = {2009},
}