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Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Al-Delaimy, WK; Ferrari, P; Slimani, N; Pala, V; Johansson, I; Nilsson, S; Mattisson, Iréne LU ; Wirfält, Elisabet LU ; Galasso, R and Palli, D, et al. (2005) In European Journal of Clinical Nutrition 59(12). p.1387-1396
Abstract
Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly... (More)
Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%). Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma. (Less)
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Contribution to journal
publication status
published
subject
keywords
questionnaires, food frequency, plasma, carotenoids, fruits and vegetables, 24 h dietary recall, EPIC
in
European Journal of Clinical Nutrition
volume
59
issue
12
pages
1387 - 1396
publisher
Nature Publishing Group
external identifiers
  • wos:000233658000007
  • pmid:16160702
  • scopus:24344434734
ISSN
1476-5640
DOI
10.1038/sj.ejcn.1602252
language
English
LU publication?
yes
id
a5e4646d-f65c-4f6a-bfe2-6e9370323380 (old id 211670)
date added to LUP
2007-08-21 11:21:24
date last changed
2017-11-19 04:08:43
@article{a5e4646d-f65c-4f6a-bfe2-6e9370323380,
  abstract     = {Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%). Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.},
  author       = {Al-Delaimy, WK and Ferrari, P and Slimani, N and Pala, V and Johansson, I and Nilsson, S and Mattisson, Iréne and Wirfält, Elisabet and Galasso, R and Palli, D and Vineis, P and Tumino, R and Dorronsoro, M and Pera, G and Ocke, MC and Bueno-de-Mesquita, HB and Overvad, K and Chirlaque, MAD and Trichopoulou, A and Naska, A and Tjonneland, A and Olsen, A and Lund, E and Alsaker, EHR and Barricarte, A and Kesse, E and Boutron-Ruault, MC and Clavel-Chapelon, F and Key, TJ and Spencer, E and Bingham, S and Welch, AA and Sanchez-Perez, MJ and Nagel, G and Linseisen, J and Quiros, JR and Peeters, PHM and van Gils, CH and Boeing, H and van Kappel, AL and Steghens, JP and Riboli, E},
  issn         = {1476-5640},
  keyword      = {questionnaires,food frequency,plasma,carotenoids,fruits and vegetables,24 h dietary recall,EPIC},
  language     = {eng},
  number       = {12},
  pages        = {1387--1396},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1602252},
  volume       = {59},
  year         = {2005},
}