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Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer : A Prospective Analysis of the EPIC Study

Almanza-Aguilera, Enrique ; Guiñón-Fort, Daniel ; Perez-Cornago, Aurora ; Martínez-Huélamo, Miriam ; Andrés-Lacueva, Cristina ; Tjønneland, Anne ; Eriksen, Anne Kirstine ; Katzke, Verena ; Bajracharya, Rashmita and Schulze, Matthias B. , et al. (2023) In Cancers 15(16).
Abstract

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models... (More)

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort, diet, EPIC, intake, polyphenols, prostate cancer
in
Cancers
volume
15
issue
16
article number
4067
publisher
MDPI AG
external identifiers
  • pmid:37627095
  • scopus:85168888820
ISSN
2072-6694
DOI
10.3390/cancers15164067
language
English
LU publication?
yes
id
2653fc03-d6af-468f-abe9-355ab68b1ecd
date added to LUP
2023-11-01 11:20:47
date last changed
2024-04-19 03:23:36
@article{2653fc03-d6af-468f-abe9-355ab68b1ecd,
  abstract     = {{<p>Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HR<sub>log2</sub> = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.</p>}},
  author       = {{Almanza-Aguilera, Enrique and Guiñón-Fort, Daniel and Perez-Cornago, Aurora and Martínez-Huélamo, Miriam and Andrés-Lacueva, Cristina and Tjønneland, Anne and Eriksen, Anne Kirstine and Katzke, Verena and Bajracharya, Rashmita and Schulze, Matthias B. and Masala, Giovanna and Oliverio, Andreina and Tumino, Rosario and Manfredi, Luca and Lasheras, Cristina and Crous-Bou, Marta and Sánchez, Maria José and Amiano, Pilar and Colorado-Yohar, Sandra M. and Guevara, Marcela and Sonestedt, Emily and Bjartell, Anders and Thysell, Elin and Weiderpass, Elisabete and Aune, Dagfinn and Aglago, Elom K. and Travis, Ruth C. and Zamora-Ros, Raul}},
  issn         = {{2072-6694}},
  keywords     = {{cohort; diet; EPIC; intake; polyphenols; prostate cancer}},
  language     = {{eng}},
  number       = {{16}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer : A Prospective Analysis of the EPIC Study}},
  url          = {{http://dx.doi.org/10.3390/cancers15164067}},
  doi          = {{10.3390/cancers15164067}},
  volume       = {{15}},
  year         = {{2023}},
}