Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
(2022) In Antioxidants 11(12).- Abstract
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using... (More)
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
(Less)
- author
- Gil-Lespinard, Mercedes
; Castañeda, Jazmín
; Almanza-Aguilera, Enrique
; Gómez, Jesús Humberto
; Tjønneland, Anne
; Kyrø, Cecilie
; Overvad, Kim
; Katzke, Verena
; Schulze, Matthias B.
; Masala, Giovanna
; Agnoli, Claudia
; Santucci de Magistris, Maria
; Tumino, Rosario
; Sacerdote, Carlotta
; Skeie, Guri
; Lasheras, Cristina
; Molina-Montes, Esther
; Huerta, José María
; Barricarte, Aurelio
; Amiano, Pilar
; Sonestedt, Emily
LU
; da Silva, Marisa
LU
; Johansson, Ingegerd
; Hultdin, Johan
; May, Anne M.
; Forouhi, Nita G.
; Heath, Alicia K.
; Freisling, Heinz
; Weiderpass, Elisabete
; Scalbert, Augustin
and Zamora-Ros, Raul
(Less) - organization
- publishing date
- 2022-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- body weight, cohort, EPIC, intake, obesity, polyphenol
- in
- Antioxidants
- volume
- 11
- issue
- 12
- article number
- 2425
- publisher
- MDPI AG
- external identifiers
-
- pmid:36552633
- scopus:85144944086
- ISSN
- 2076-3921
- DOI
- 10.3390/antiox11122425
- language
- English
- LU publication?
- yes
- id
- 29c3bb79-116b-45ee-b94a-a4f1159e54b9
- date added to LUP
- 2023-01-05 10:27:05
- date last changed
- 2024-04-18 18:25:16
@article{29c3bb79-116b-45ee-b94a-a4f1159e54b9,
abstract = {{<p>Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.</p>}},
author = {{Gil-Lespinard, Mercedes and Castañeda, Jazmín and Almanza-Aguilera, Enrique and Gómez, Jesús Humberto and Tjønneland, Anne and Kyrø, Cecilie and Overvad, Kim and Katzke, Verena and Schulze, Matthias B. and Masala, Giovanna and Agnoli, Claudia and Santucci de Magistris, Maria and Tumino, Rosario and Sacerdote, Carlotta and Skeie, Guri and Lasheras, Cristina and Molina-Montes, Esther and Huerta, José María and Barricarte, Aurelio and Amiano, Pilar and Sonestedt, Emily and da Silva, Marisa and Johansson, Ingegerd and Hultdin, Johan and May, Anne M. and Forouhi, Nita G. and Heath, Alicia K. and Freisling, Heinz and Weiderpass, Elisabete and Scalbert, Augustin and Zamora-Ros, Raul}},
issn = {{2076-3921}},
keywords = {{body weight; cohort; EPIC; intake; obesity; polyphenol}},
language = {{eng}},
number = {{12}},
publisher = {{MDPI AG}},
series = {{Antioxidants}},
title = {{Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort}},
url = {{http://dx.doi.org/10.3390/antiox11122425}},
doi = {{10.3390/antiox11122425}},
volume = {{11}},
year = {{2022}},
}