Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
(2021) In International Journal of Cancer 149(4). p.865-882- Abstract
Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard... (More)
Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.
(Less)
- author
- organization
- publishing date
- 2021-08-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarker, colorectal cancer, dietary intake, fatty acids
- in
- International Journal of Cancer
- volume
- 149
- issue
- 4
- pages
- 18 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85105928331
- pmid:33913149
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.33615
- language
- English
- LU publication?
- yes
- id
- 2bd2ec4c-4279-4b78-86b9-2c332187b26e
- date added to LUP
- 2021-06-10 11:04:13
- date last changed
- 2024-06-15 12:22:49
@article{2bd2ec4c-4279-4b78-86b9-2c332187b26e,
abstract = {{<p>Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HR<sub>Q5vsQ1</sub> = 0.80; 95%CI:0.69-0.92), myristic acid (HR<sub>Q5vsQ1</sub> = 0.83, 95%CI:0.74-0.93) and palmitic acid (HR<sub>Q5vsQ1</sub> = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, OR<sub>Q4vsQ1</sub> = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (OR<sub>Q4vsQ1</sub> = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR<sub>1-SD</sub> = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR<sub>1-SD</sub> = 1.04, 95%CI:0.95-1.15, P<sub>heterogeneity</sub> = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR<sub>1-SD</sub> = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.</p>}},
author = {{Aglago, Elom K. and Murphy, Neil and Huybrechts, Inge and Nicolas, Geneviève and Casagrande, Corinne and Fedirko, Veronika and Weiderpass, Elisabete and Rothwell, Joseph A. and Dahm, Christina C. and Olsen, Anja and Tjønneland, Anne and Kaaks, Rudolf and Katzke, Verena and Schulze, Matthias B. and Masala, Giovanna and Agnoli, Claudia and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Bueno-de-Mesquita, Bas H. and Derksen, Jeroen W.G. and Skeie, Guri and Gram, Inger Torhild and Brustad, Magritt and Jakszyn, Paula and Sánchez, Maria Jose and Amiano, Pilar and Huerta, José María and Ericson, Ulrika and Wennberg, Maria and Perez-Cornago, Aurora and Heath, Alicia K. and Jenab, Mazda and Chajes, Veronique and Gunter, Marc J.}},
issn = {{0020-7136}},
keywords = {{biomarker; colorectal cancer; dietary intake; fatty acids}},
language = {{eng}},
month = {{08}},
number = {{4}},
pages = {{865--882}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort}},
url = {{http://dx.doi.org/10.1002/ijc.33615}},
doi = {{10.1002/ijc.33615}},
volume = {{149}},
year = {{2021}},
}