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Polyphenol intake and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (Epic) study

Londoño, Catalina ; Cayssials, Valerie ; de Villasante, Izar ; Crous-Bou, Marta ; Scalbert, Augustin ; Weiderpass, Elisabete ; Agudo, Antonio ; Tjønneland, Anne ; Olsen, Anja and Overvad, Kim , et al. (2021) In Antioxidants 10(8).
Abstract

Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up... (More)

Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1 ) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort, EPIC, Flavonoids, Intake, Ovarian cancer, Polyphenols
in
Antioxidants
volume
10
issue
8
article number
1249
publisher
MDPI AG
external identifiers
  • pmid:34439497
  • scopus:85111783395
ISSN
2076-3921
DOI
10.3390/antiox10081249
language
English
LU publication?
yes
id
4ad9e1e6-4375-44de-9a92-b5a6d62f5a0b
date added to LUP
2021-08-26 14:51:29
date last changed
2022-12-01 17:41:48
@article{4ad9e1e6-4375-44de-9a92-b5a6d62f5a0b,
  abstract     = {{<p>Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HR<sub>Q4vsQ1</sub> ) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HR<sub>Q4vsQ1</sub> = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.</p>}},
  author       = {{Londoño, Catalina and Cayssials, Valerie and de Villasante, Izar and Crous-Bou, Marta and Scalbert, Augustin and Weiderpass, Elisabete and Agudo, Antonio and Tjønneland, Anne and Olsen, Anja and Overvad, Kim and Katzke, Verena and Schulze, Matthias and Palli, Domenico and Krogh, Vittorio and de Magistris, Maria Santucci and Tumino, Rosario and Ricceri, Fulvio and Gram, Inger T. and Rylander, Charlotta and Skeie, Guri and Sánchez, Maria Jose and Amiano, Pilar and Huerta, José María and Barricarte, Aurelio and Sartor, Hanna and Sonestedt, Emily and Esberg, Anders and Idahl, Annika and Mahamat-Saleh, Yahya and Laouali, Nasser and Kvaskoff, Marina and Turzanski-Fortner, Renée and Zamora-Ros, Raul}},
  issn         = {{2076-3921}},
  keywords     = {{Cohort; EPIC; Flavonoids; Intake; Ovarian cancer; Polyphenols}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{MDPI AG}},
  series       = {{Antioxidants}},
  title        = {{Polyphenol intake and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (Epic) study}},
  url          = {{http://dx.doi.org/10.3390/antiox10081249}},
  doi          = {{10.3390/antiox10081249}},
  volume       = {{10}},
  year         = {{2021}},
}