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Association of nut and seed intake with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition

Jenab, M; Ferrari, P; Slimani, N; Norat, T; Casagrande, C; Overad, K; Olsen, A; Stripp, C; Tjonneland, A and Boutron-Ruault, MC, et al. (2004) In Cancer Epidemiology Biomarkers & Prevention 13(10). p.1595-1603
Abstract
A link between unsaturated fatty acids or phytonutrients and reduced risk of colorectal cancer has been suggested. However, the effects of higher intake of dietary sources of these nutrients, such as the nuts and seeds food group, are less clear. The objective of this study was to determine the effects of nut and seed intake on colorectal cancer risk within the European Prospective Investigation into Cancer and Nutrition study, a large prospective cohort study involving 10 European countries. Total nut and seed intake was determined from country-specific dietary questionnaires. The data set included 478,040 subjects (141,988 men, 336,052 women) with a total of 855 (327 men, 528 women) colon and 474 (215 men, 259 women) rectal cancer cases.... (More)
A link between unsaturated fatty acids or phytonutrients and reduced risk of colorectal cancer has been suggested. However, the effects of higher intake of dietary sources of these nutrients, such as the nuts and seeds food group, are less clear. The objective of this study was to determine the effects of nut and seed intake on colorectal cancer risk within the European Prospective Investigation into Cancer and Nutrition study, a large prospective cohort study involving 10 European countries. Total nut and seed intake was determined from country-specific dietary questionnaires. The data set included 478,040 subjects (141,988 men, 336,052 women) with a total of 855 (327 men, 528 women) colon and 474 (215 men, 259 women) rectal cancer cases. A multivariate Cox proportional hazards model, stratified by center and controlled for fruit intake, dietary fiber, energy, height, weight, sex, age, physical activity, and smoking, was used. The data show no association between higher intake of nuts and seeds and risk of colorectal, colon, and rectal cancers in men and women combined, but a significant inverse association was observed in subgroup analyses for colon cancer in women at the highest (>6.2 g/d) versus the lowest (nonconsumers; hazard ratio, 0.69;, 95% confidence interval, 0.50-0.95) category of intake and for the linear effect of log-transformed intake (hazard ratio, 0.89; 95% confidence interval, 0.80-0.98), with no associations in men. It is not evident from this data why there may be a stronger association in women or why it may be limited to the colon, suggesting that much, further research is necessary. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
13
issue
10
pages
1595 - 1603
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American Association for Cancer Research
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  • pmid:15466975
  • wos:000224453700009
  • scopus:4944257154
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1538-7755
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English
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7fda76fb-ede6-4dc6-987d-7ce5b45fced6 (old id 898068)
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http://cebp.aacrjournals.org/cgi/content/abstract/13/10/1595
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@article{7fda76fb-ede6-4dc6-987d-7ce5b45fced6,
  abstract     = {A link between unsaturated fatty acids or phytonutrients and reduced risk of colorectal cancer has been suggested. However, the effects of higher intake of dietary sources of these nutrients, such as the nuts and seeds food group, are less clear. The objective of this study was to determine the effects of nut and seed intake on colorectal cancer risk within the European Prospective Investigation into Cancer and Nutrition study, a large prospective cohort study involving 10 European countries. Total nut and seed intake was determined from country-specific dietary questionnaires. The data set included 478,040 subjects (141,988 men, 336,052 women) with a total of 855 (327 men, 528 women) colon and 474 (215 men, 259 women) rectal cancer cases. A multivariate Cox proportional hazards model, stratified by center and controlled for fruit intake, dietary fiber, energy, height, weight, sex, age, physical activity, and smoking, was used. The data show no association between higher intake of nuts and seeds and risk of colorectal, colon, and rectal cancers in men and women combined, but a significant inverse association was observed in subgroup analyses for colon cancer in women at the highest (>6.2 g/d) versus the lowest (nonconsumers; hazard ratio, 0.69;, 95% confidence interval, 0.50-0.95) category of intake and for the linear effect of log-transformed intake (hazard ratio, 0.89; 95% confidence interval, 0.80-0.98), with no associations in men. It is not evident from this data why there may be a stronger association in women or why it may be limited to the colon, suggesting that much, further research is necessary.},
  author       = {Jenab, M and Ferrari, P and Slimani, N and Norat, T and Casagrande, C and Overad, K and Olsen, A and Stripp, C and Tjonneland, A and Boutron-Ruault, MC and Clavel-Chapelon, F and Kesse, E and Nieters, A and Bergmann, M and Boeing, H and Naska, A and Trichopoulou, A and Palli, D and Krogh, V and Celentano, E and Tumino, R and Sacerdote, C and Bueno-de-Mesquita, HB and Ocke, MC and Peeters, PHM and Engeset, D and Quiros, JR and Gonzalez, CA and Martinez, C and Chirlaque, MD and Ardanaz, E and Dorronsoro, M and Wallström, Peter and Palmqvist, R and Van Guelpen, B and Bingham, S and Joaquin, MAS and Saracci, R and Kaaks, R and Riboli, E},
  issn         = {1538-7755},
  language     = {eng},
  number       = {10},
  pages        = {1595--1603},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Association of nut and seed intake with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  volume       = {13},
  year         = {2004},
}