Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition
(2021) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 30(6). p.1270-1274- Abstract
BACKGROUND: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
METHODS: A total of 389,220 EPIC participants with median age of 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for RCC incidence and... (More)
BACKGROUND: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
METHODS: A total of 389,220 EPIC participants with median age of 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially sweetened soft drinks.
RESULTS: A total of 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment = 1.03; 95% CI, 0.97-1.09), total soft drinks (HR = 1.01; 95% CI, 0.98-1.05), sugar-sweetened soft drinks (HR = 0.99; 95% CI, 0.94-1.05), or artificially sweetened soft drinks (HR = 1.02; 95% CI, 0.96-1.08). In these fully adjusted models, none of the beverages was associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively).
CONCLUSIONS: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity.
IMPACT: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.
(Less)
- author
- Heath, Alicia K
; Clasen, Joanna L
; Jayanth, Nick P
; Jenab, Mazda
; Tjønneland, Anne
; Petersen, Kristina Elin Nielsen
; Overvad, Kim
; Srour, Bernard
; Katzke, Verena
; Bergmann, Manuela M
; Schulze, Matthias B
; Masala, Giovanna
; Krogh, Vittorio
; Tumino, Rosario
; Catalano, Alberto
; Pasanisi, Fabrizio
; Brustad, Magritt
; Olsen, Karina Standahl
; Skeie, Guri
; Luján-Barroso, Leila
; Rodríguez-Barranco, Miguel
; Amiano, Pilar
; Santiuste, Carmen
; Barricarte Gurrea, Aurelio
; Axelson, Håkan
LU
; Ramne, Stina
LU
; Ljungberg, Börje
; Watts, Eleanor L
; Huybrechts, Inge
; Weiderpass, Elisabete
; Riboli, Elio
and Muller, David C
(Less) - organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- volume
- 30
- issue
- 6
- pages
- 1270 - 1274
- publisher
- American Association for Cancer Research
- external identifiers
-
- pmid:33849969
- scopus:85106999926
- ISSN
- 1538-7755
- DOI
- 10.1158/1055-9965.EPI-20-1726
- language
- English
- LU publication?
- yes
- additional info
- ©2021 American Association for Cancer Research.
- id
- 8fa08d01-c56a-4bcc-9898-e5094170ba9b
- date added to LUP
- 2021-10-16 23:06:05
- date last changed
- 2024-06-15 18:15:43
@article{8fa08d01-c56a-4bcc-9898-e5094170ba9b,
abstract = {{<p>BACKGROUND: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).</p><p>METHODS: A total of 389,220 EPIC participants with median age of 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially sweetened soft drinks.</p><p>RESULTS: A total of 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment = 1.03; 95% CI, 0.97-1.09), total soft drinks (HR = 1.01; 95% CI, 0.98-1.05), sugar-sweetened soft drinks (HR = 0.99; 95% CI, 0.94-1.05), or artificially sweetened soft drinks (HR = 1.02; 95% CI, 0.96-1.08). In these fully adjusted models, none of the beverages was associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively).</p><p>CONCLUSIONS: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity.</p><p>IMPACT: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.</p>}},
author = {{Heath, Alicia K and Clasen, Joanna L and Jayanth, Nick P and Jenab, Mazda and Tjønneland, Anne and Petersen, Kristina Elin Nielsen and Overvad, Kim and Srour, Bernard and Katzke, Verena and Bergmann, Manuela M and Schulze, Matthias B and Masala, Giovanna and Krogh, Vittorio and Tumino, Rosario and Catalano, Alberto and Pasanisi, Fabrizio and Brustad, Magritt and Olsen, Karina Standahl and Skeie, Guri and Luján-Barroso, Leila and Rodríguez-Barranco, Miguel and Amiano, Pilar and Santiuste, Carmen and Barricarte Gurrea, Aurelio and Axelson, Håkan and Ramne, Stina and Ljungberg, Börje and Watts, Eleanor L and Huybrechts, Inge and Weiderpass, Elisabete and Riboli, Elio and Muller, David C}},
issn = {{1538-7755}},
language = {{eng}},
number = {{6}},
pages = {{1270--1274}},
publisher = {{American Association for Cancer Research}},
series = {{Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}},
title = {{Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition}},
url = {{http://dx.doi.org/10.1158/1055-9965.EPI-20-1726}},
doi = {{10.1158/1055-9965.EPI-20-1726}},
volume = {{30}},
year = {{2021}},
}