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Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Agudo, Antonio; Cayssials, Valerie; Bonet, Catalina; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie Christine; Affret, Aurélie; Fagherazzi, Guy; Katzke, Verena and Schübel, Ruth, et al. (2018) In American Journal of Clinical Nutrition 107(4). p.607-616
Abstract

Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. Design A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and... (More)

Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. Design A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders. Results The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively. Conclusions Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.

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published
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keywords
chronic inflammation, gastric cancer, inflammatory score of the diet, nutrition, prospective studies
in
American Journal of Clinical Nutrition
volume
107
issue
4
pages
10 pages
publisher
American Society for Clinical Nutrition
external identifiers
  • scopus:85045851436
ISSN
0002-9165
DOI
10.1093/ajcn/nqy002
language
English
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yes
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8fd9d7a8-0f74-45ed-9b7d-cdabb2fa0702
date added to LUP
2018-05-02 16:13:50
date last changed
2019-02-20 11:16:00
@article{8fd9d7a8-0f74-45ed-9b7d-cdabb2fa0702,
  abstract     = {<p>Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers. Design A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders. Results The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively. Conclusions Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.</p>},
  author       = {Agudo, Antonio and Cayssials, Valerie and Bonet, Catalina and Tjønneland, Anne and Overvad, Kim and Boutron-Ruault, Marie Christine and Affret, Aurélie and Fagherazzi, Guy and Katzke, Verena and Schübel, Ruth and Trichopoulou, Antonia and Karakatsani, Anna and La Vecchia, Carlo and Palli, Domenico and Grioni, Sara and Tumino, Rosario and Ricceri, Fulvio and Panico, Salvatore and Bueno-De-Mesquita, Bas and Peeters, Petra H. and Weiderpass, Elisabete and Skeie, Guri and Nøst, Theresa H. and Lasheras, Cristina and Rodríguez-Barranco, Miguel and Amiano, Pilar and Chirlaque, María Dolores and Ardanaz, Eva and Ohlsson, Bodil and Dias, Joana A. and Nilsson, Lena M. and Myte, Robin and Khaw, Kay Tee and Perez-Cornago, Aurora and Gunter, Marc and Huybrechts, Inge and Cross, Amanda J. and Tsilidis, Kostas and Riboli, Elio and Jakszyn, Paula},
  issn         = {0002-9165},
  keyword      = {chronic inflammation,gastric cancer,inflammatory score of the diet,nutrition,prospective studies},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {607--616},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.1093/ajcn/nqy002},
  volume       = {107},
  year         = {2018},
}