Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Metabolic Effects of Gastric Bypass Surgery : Is It All About Calories?

Herzog, Katharina LU ; Berggren, Johan LU ; Al Majdoub, Mahmoud LU ; Balderas Arroyo, Claudia LU ; Lindqvist, Andreas LU ; Hedenbro, Jan LU ; Groop, Leif LU ; Wierup, Nils LU and Spégel, Peter LU (2020) In Diabetes 69(9). p.2027-2035
Abstract

Bariatric surgery is an efficient method to induce weight loss and also, frequently, remission of type 2 diabetes (T2D). Unpaired studies have shown bariatric surgery and dietary interventions to differentially affect multiple hormonal and metabolic parameters, suggesting that bariatric surgery causes T2D remission at least partially via unique mechanisms. In the current study, plasma metabolite profiling was conducted in patients with (n = 10) and without T2D (n = 9) subjected to Roux-en-Y gastric bypass surgery (RYGB). Mixed-meal tests were conducted at baseline, after the presurgical very-low-calorie diet (VLCD) intervention, immediately after RYGB, and after a 6-week recovery period. Thereby, we could compare fasted and postprandial... (More)

Bariatric surgery is an efficient method to induce weight loss and also, frequently, remission of type 2 diabetes (T2D). Unpaired studies have shown bariatric surgery and dietary interventions to differentially affect multiple hormonal and metabolic parameters, suggesting that bariatric surgery causes T2D remission at least partially via unique mechanisms. In the current study, plasma metabolite profiling was conducted in patients with (n = 10) and without T2D (n = 9) subjected to Roux-en-Y gastric bypass surgery (RYGB). Mixed-meal tests were conducted at baseline, after the presurgical very-low-calorie diet (VLCD) intervention, immediately after RYGB, and after a 6-week recovery period. Thereby, we could compare fasted and postprandial metabolic consequences of RYGB and VLCD in the same patients. VLCD yielded a pronounced increase in fasting acylcarnitine levels, whereas RYGB, both immediately and after a recovery period, resulted in a smaller but opposite effect. Furthermore, we observed profound changes in lipid metabolism following VLCD but not in response to RYGB. Most changes previously associated with RYGB were found to be consequences of the presurgical dietary intervention. Overall, our results question previous findings of unique metabolic effects of RYGB and suggest that the effect of RYGB on the metabolite profile is mainly attributed to caloric restriction.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
69
issue
9
pages
9 pages
publisher
American Diabetes Association Inc.
external identifiers
  • pmid:32527768
  • scopus:85089787182
ISSN
1939-327X
DOI
10.2337/db20-0131
language
English
LU publication?
yes
id
9c893bbc-79d3-4728-8acf-eaf818b5b9cd
date added to LUP
2020-09-07 11:35:44
date last changed
2024-05-02 15:09:38
@article{9c893bbc-79d3-4728-8acf-eaf818b5b9cd,
  abstract     = {{<p>Bariatric surgery is an efficient method to induce weight loss and also, frequently, remission of type 2 diabetes (T2D). Unpaired studies have shown bariatric surgery and dietary interventions to differentially affect multiple hormonal and metabolic parameters, suggesting that bariatric surgery causes T2D remission at least partially via unique mechanisms. In the current study, plasma metabolite profiling was conducted in patients with (n = 10) and without T2D (n = 9) subjected to Roux-en-Y gastric bypass surgery (RYGB). Mixed-meal tests were conducted at baseline, after the presurgical very-low-calorie diet (VLCD) intervention, immediately after RYGB, and after a 6-week recovery period. Thereby, we could compare fasted and postprandial metabolic consequences of RYGB and VLCD in the same patients. VLCD yielded a pronounced increase in fasting acylcarnitine levels, whereas RYGB, both immediately and after a recovery period, resulted in a smaller but opposite effect. Furthermore, we observed profound changes in lipid metabolism following VLCD but not in response to RYGB. Most changes previously associated with RYGB were found to be consequences of the presurgical dietary intervention. Overall, our results question previous findings of unique metabolic effects of RYGB and suggest that the effect of RYGB on the metabolite profile is mainly attributed to caloric restriction.</p>}},
  author       = {{Herzog, Katharina and Berggren, Johan and Al Majdoub, Mahmoud and Balderas Arroyo, Claudia and Lindqvist, Andreas and Hedenbro, Jan and Groop, Leif and Wierup, Nils and Spégel, Peter}},
  issn         = {{1939-327X}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2027--2035}},
  publisher    = {{American Diabetes Association Inc.}},
  series       = {{Diabetes}},
  title        = {{Metabolic Effects of Gastric Bypass Surgery : Is It All About Calories?}},
  url          = {{http://dx.doi.org/10.2337/db20-0131}},
  doi          = {{10.2337/db20-0131}},
  volume       = {{69}},
  year         = {{2020}},
}