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Xylooligosaccharides Increase Bifidobacteria and Lachnospiraceae in Mice on a High-Fat Diet, with a Concomitant Increase in Short-Chain Fatty Acids, Especially Butyric Acid

Berger, Karin LU orcid ; Burleigh, Stephen LU ; Lindahl, Maria LU ; Bhattacharya, Abhishek ; Patil, Prachiti ; Stålbrand, Henrik LU ; Nordberg Karlsson, Eva LU orcid ; Hållenius, Frida LU orcid ; Nyman, Margareta LU and Adlercreutz, Patrick LU orcid (2021) In Journal of Agricultural and Food Chemistry 69(12). p.3617-3625
Abstract

Effects of xylooligosaccharides (XOSs) as well as a mixture of XOS, inulin, oligofructose, and partially hydrolyzed guar gum (MIX) in mice fed a high-fat diet (HFD) were studied. Control groups were fed an HFD or a low-fat diet. Special attention was paid to the cecal composition of the gut microbiota and formation of short-chain fatty acids, but metabolic parameters were also documented. The XOS group had significantly higher cecum levels of acetic, propionic, and butyric acids than the HFD group, and the butyric acid content was higher in the XOS than in the MIX group. The cecum microbiota of the XOS group contained more Bifidobacteria, Lachnospiraceae, and S24-7 bacteria than the HFD group. A tendency of lower body... (More)

Effects of xylooligosaccharides (XOSs) as well as a mixture of XOS, inulin, oligofructose, and partially hydrolyzed guar gum (MIX) in mice fed a high-fat diet (HFD) were studied. Control groups were fed an HFD or a low-fat diet. Special attention was paid to the cecal composition of the gut microbiota and formation of short-chain fatty acids, but metabolic parameters were also documented. The XOS group had significantly higher cecum levels of acetic, propionic, and butyric acids than the HFD group, and the butyric acid content was higher in the XOS than in the MIX group. The cecum microbiota of the XOS group contained more Bifidobacteria, Lachnospiraceae, and S24-7 bacteria than the HFD group. A tendency of lower body weight gain was observed on comparing the XOS and HFD groups. In conclusion, the XOS was shown to be a promising prebiotic candidate. The fiber diversity in the MIX diet did not provide any advantages compared to the XOS diet.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Prebiotics, Xylooligosaccharides, Bifidobacteria, Lachnospiraceae, S24-7, Short-chain fatty acids, Butyrate, High-fat diet
in
Journal of Agricultural and Food Chemistry
volume
69
issue
12
pages
3617 - 3625
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:33724030
  • scopus:85103616701
ISSN
0021-8561
DOI
10.1021/acs.jafc.0c06279
language
English
LU publication?
yes
id
affde380-de99-4bb2-a21b-72043c47af44
date added to LUP
2021-03-19 14:01:18
date last changed
2025-04-18 14:54:41
@article{affde380-de99-4bb2-a21b-72043c47af44,
  abstract     = {{<p>Effects of xylooligosaccharides (XOSs) as well as a mixture of XOS, inulin, oligofructose, and partially hydrolyzed guar gum (MIX) in mice fed a high-fat diet (HFD) were studied. Control groups were fed an HFD or a low-fat diet. Special attention was paid to the cecal composition of the gut microbiota and formation of short-chain fatty acids, but metabolic parameters were also documented. The XOS group had significantly higher cecum levels of acetic, propionic, and butyric acids than the HFD group, and the butyric acid content was higher in the XOS than in the MIX group. The cecum microbiota of the XOS group contained more <i>Bifidobacteria</i>, <i>Lachnospiraceae</i>, and S24-7 bacteria than the HFD group. A tendency of lower body weight gain was observed on comparing the XOS and HFD groups. In conclusion, the XOS was shown to be a promising prebiotic candidate. The fiber diversity in the MIX diet did not provide any advantages compared to the XOS diet.</p>}},
  author       = {{Berger, Karin and Burleigh, Stephen and Lindahl, Maria and Bhattacharya, Abhishek and Patil, Prachiti and Stålbrand, Henrik and Nordberg Karlsson, Eva and Hållenius, Frida and Nyman, Margareta and Adlercreutz, Patrick}},
  issn         = {{0021-8561}},
  keywords     = {{Prebiotics; Xylooligosaccharides; Bifidobacteria; Lachnospiraceae; S24-7; Short-chain fatty acids; Butyrate; High-fat diet}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{12}},
  pages        = {{3617--3625}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Agricultural and Food Chemistry}},
  title        = {{Xylooligosaccharides Increase Bifidobacteria and Lachnospiraceae in Mice on a High-Fat Diet, with a Concomitant Increase in Short-Chain Fatty Acids, Especially Butyric Acid}},
  url          = {{http://dx.doi.org/10.1021/acs.jafc.0c06279}},
  doi          = {{10.1021/acs.jafc.0c06279}},
  volume       = {{69}},
  year         = {{2021}},
}