Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Metabolic remission precedes possible weight regain after gastric bypass surgery

Rogova, Oksana LU ; Herzog, Katharina LU ; Al-Majdoub, Mahmoud LU ; Miskelly, Michael LU ; Lindqvist, Andreas LU ; Bennet, Louise LU orcid ; Hedenbro, Jan L LU ; Wierup, Nils LU and Spégel, Peter LU (2023) In Obesity 31(10). p.2530-2542
Abstract

OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.

METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.

RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2... (More)

OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.

METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.

RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2 months post RYGB. Notably, thereafter the metabolome started to return toward the presurgical state. Consequently, a close-to-presurgical metabolome was observed at the time when patients reached their lowest weight and glucose level. Lipids with longer acyl chains and a higher degree of unsaturation were altered more dramatically compared with shorter and more saturated lipids, suggesting a systematic and reversible lipid remodeling.

CONCLUSIONS: Remission of the metabolic state was observed prior to notable weight regain. Further and more long-term studies are required to assess whether the extent of metabolic remission predicts future weight regain and glycemic deterioration.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
31
issue
10
pages
2530 - 2542
publisher
Nature Publishing Group
external identifiers
  • scopus:85168110045
  • pmid:37587639
ISSN
1930-739X
DOI
10.1002/oby.23864
language
English
LU publication?
yes
additional info
© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
id
b2d68ee1-b28e-4120-ada4-4917fd305951
alternative location
https://onlinelibrary.wiley.com/doi/10.1002/oby.23864
date added to LUP
2023-08-18 13:00:40
date last changed
2024-04-25 06:11:24
@article{b2d68ee1-b28e-4120-ada4-4917fd305951,
  abstract     = {{<p>OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.</p><p>METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.</p><p>RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2 months post RYGB. Notably, thereafter the metabolome started to return toward the presurgical state. Consequently, a close-to-presurgical metabolome was observed at the time when patients reached their lowest weight and glucose level. Lipids with longer acyl chains and a higher degree of unsaturation were altered more dramatically compared with shorter and more saturated lipids, suggesting a systematic and reversible lipid remodeling.</p><p>CONCLUSIONS: Remission of the metabolic state was observed prior to notable weight regain. Further and more long-term studies are required to assess whether the extent of metabolic remission predicts future weight regain and glycemic deterioration.</p>}},
  author       = {{Rogova, Oksana and Herzog, Katharina and Al-Majdoub, Mahmoud and Miskelly, Michael and Lindqvist, Andreas and Bennet, Louise and Hedenbro, Jan L and Wierup, Nils and Spégel, Peter}},
  issn         = {{1930-739X}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{10}},
  pages        = {{2530--2542}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Obesity}},
  title        = {{Metabolic remission precedes possible weight regain after gastric bypass surgery}},
  url          = {{http://dx.doi.org/10.1002/oby.23864}},
  doi          = {{10.1002/oby.23864}},
  volume       = {{31}},
  year         = {{2023}},
}