Metabolic remission precedes possible weight regain after gastric bypass surgery
(2023) In Obesity 31(10). p.2530-2542- Abstract
OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.
METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.
RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2... (More)
OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.
METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.
RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2 months post RYGB. Notably, thereafter the metabolome started to return toward the presurgical state. Consequently, a close-to-presurgical metabolome was observed at the time when patients reached their lowest weight and glucose level. Lipids with longer acyl chains and a higher degree of unsaturation were altered more dramatically compared with shorter and more saturated lipids, suggesting a systematic and reversible lipid remodeling.
CONCLUSIONS: Remission of the metabolic state was observed prior to notable weight regain. Further and more long-term studies are required to assess whether the extent of metabolic remission predicts future weight regain and glycemic deterioration.
(Less)
- author
- Rogova, Oksana LU ; Herzog, Katharina LU ; Al-Majdoub, Mahmoud LU ; Miskelly, Michael LU ; Lindqvist, Andreas LU ; Bennet, Louise LU ; Hedenbro, Jan L LU ; Wierup, Nils LU and Spégel, Peter LU
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- Centre for Analysis and Synthesis
- Diabetes - Molecular Metabolism (research group)
- Neuroendocrine Cell Biology (research group)
- LUDC (Lund University Diabetes Centre)-lup-obsolete (research group)
- EpiHealth: Epidemiology for Health
- Family Medicine and Community Medicine (research group)
- publishing date
- 2023-08-16
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Obesity
- volume
- 31
- issue
- 10
- pages
- 2530 - 2542
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85168110045
- pmid:37587639
- ISSN
- 1930-739X
- DOI
- 10.1002/oby.23864
- language
- English
- LU publication?
- yes
- additional info
- © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
- id
- b2d68ee1-b28e-4120-ada4-4917fd305951
- alternative location
- https://onlinelibrary.wiley.com/doi/10.1002/oby.23864
- date added to LUP
- 2023-08-18 13:00:40
- date last changed
- 2024-04-25 06:11:24
@article{b2d68ee1-b28e-4120-ada4-4917fd305951, abstract = {{<p>OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.</p><p>METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.</p><p>RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2 months post RYGB. Notably, thereafter the metabolome started to return toward the presurgical state. Consequently, a close-to-presurgical metabolome was observed at the time when patients reached their lowest weight and glucose level. Lipids with longer acyl chains and a higher degree of unsaturation were altered more dramatically compared with shorter and more saturated lipids, suggesting a systematic and reversible lipid remodeling.</p><p>CONCLUSIONS: Remission of the metabolic state was observed prior to notable weight regain. Further and more long-term studies are required to assess whether the extent of metabolic remission predicts future weight regain and glycemic deterioration.</p>}}, author = {{Rogova, Oksana and Herzog, Katharina and Al-Majdoub, Mahmoud and Miskelly, Michael and Lindqvist, Andreas and Bennet, Louise and Hedenbro, Jan L and Wierup, Nils and Spégel, Peter}}, issn = {{1930-739X}}, language = {{eng}}, month = {{08}}, number = {{10}}, pages = {{2530--2542}}, publisher = {{Nature Publishing Group}}, series = {{Obesity}}, title = {{Metabolic remission precedes possible weight regain after gastric bypass surgery}}, url = {{http://dx.doi.org/10.1002/oby.23864}}, doi = {{10.1002/oby.23864}}, volume = {{31}}, year = {{2023}}, }