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Physical activity and survival following breast cancer

Johnsson, Anna LU ; Broberg, Per LU ; Krüger, Ute LU ; Johnsson, Anders LU ; Tornberg, Åsa LU and Olsson, Håkan LU (2019) In European Journal of Cancer Care
Abstract
INTRODUCTION:
Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.
METHODS:
From a prospective population-based cohort of Swedish women, we included 847 women, aged 34-84 years, who were diagnosed with breast cancer from 1992 to 2012. A PA score was calculated based on three different questions regarding self-reported PA. Cox proportional hazard model was used to estimate the association between PA and mortality.
RESULTS:
A significant... (More)
INTRODUCTION:
Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.
METHODS:
From a prospective population-based cohort of Swedish women, we included 847 women, aged 34-84 years, who were diagnosed with breast cancer from 1992 to 2012. A PA score was calculated based on three different questions regarding self-reported PA. Cox proportional hazard model was used to estimate the association between PA and mortality.
RESULTS:
A significant association between PA score and all-cause mortality was observed, in a dose-response manner (ptrend = 0.01). The mortality was clearly lower in the most active compared to the least active group (hazard ratio 0.29, 95% confidence intervals 0.09-0.90). A subgroup analysis showed that the improved survival was only seen in women over 55 years of age at diagnosis.
CONCLUSION:
Physical activity, which is a modifiable lifestyle factor, should be encouraged after breast cancer diagnosis, especially in women with post-menopausal breast cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
European Journal of Cancer Care
publisher
John Wiley & Sons
external identifiers
  • scopus:85063164662
ISSN
1365-2354
DOI
10.1111/ecc.13037
language
English
LU publication?
yes
id
ed5acd65-2655-4a0e-8707-d4718efc13c9
date added to LUP
2019-03-22 13:22:35
date last changed
2019-04-23 04:47:16
@article{ed5acd65-2655-4a0e-8707-d4718efc13c9,
  abstract     = {INTRODUCTION:<br/>Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.<br/>METHODS:<br/>From a prospective population-based cohort of Swedish women, we included 847 women, aged 34-84 years, who were diagnosed with breast cancer from 1992 to 2012. A PA score was calculated based on three different questions regarding self-reported PA. Cox proportional hazard model was used to estimate the association between PA and mortality.<br/>RESULTS:<br/>A significant association between PA score and all-cause mortality was observed, in a dose-response manner (ptrend  = 0.01). The mortality was clearly lower in the most active compared to the least active group (hazard ratio 0.29, 95% confidence intervals 0.09-0.90). A subgroup analysis showed that the improved survival was only seen in women over 55 years of age at diagnosis.<br/>CONCLUSION:<br/>Physical activity, which is a modifiable lifestyle factor, should be encouraged after breast cancer diagnosis, especially in women with post-menopausal breast cancer.},
  articleno    = {e13037},
  author       = {Johnsson, Anna and Broberg, Per and Krüger, Ute and Johnsson, Anders and Tornberg, Åsa and Olsson, Håkan},
  issn         = {1365-2354},
  language     = {eng},
  month        = {03},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Cancer Care},
  title        = {Physical activity and survival following breast cancer},
  url          = {http://dx.doi.org/10.1111/ecc.13037},
  year         = {2019},
}