Brain Repair and Imaging in Neural Systems (BRAINS)
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- 2024
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Mark
Basal activity of PINK1 and PRKN in cell models and rodent brain
(
- Contribution to journal › Article
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Mark
Image post-processing for SILMAS : structured illumination light sheet microscopy with axial sweeping
(
- Contribution to journal › Article
- 2023
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Mark
Immune response in blood before and after epileptic and psychogenic non-epileptic seizures
(
- Contribution to journal › Article
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Mark
Reduced epilepsy development in synapsin 2 knockout mice with autistic behavior following early systemic treatment with interleukin-6 receptor antibody
(
- Contribution to journal › Article
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Mark
Cell-specific switch for epileptiform activity : critical role of interneurons in the mouse subicular network
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- Contribution to journal › Article
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Mark
Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation
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- Contribution to journal › Article
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Mark
Optogenetics for controlling seizure circuits for translational approaches
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- Contribution to journal › Article
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Mark
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease
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- Contribution to journal › Article
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Mark
Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene
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- Contribution to journal › Article
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Mark
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease
(
- Contribution to journal › Article
- 2022
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Mark
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
(
- Contribution to journal › Article
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Mark
High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping
(
- Contribution to journal › Article
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Mark
Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
(
- Contribution to journal › Article
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Mark
Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats
(
- Contribution to journal › Article
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Mark
Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients
(
- Contribution to journal › Article
- 2021
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Mark
Structured light sheet microscopy for high contrast 3D imaging of whole mouse brain
2021) Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 In Optics InfoBase Conference Papers(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease
(
- Contribution to journal › Article
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Mark
Early white matter pathology in the fornix of the limbic system in Huntington disease
(
- Contribution to journal › Article
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Mark
Viral-based rodent and nonhuman primate models of multiple system atrophy : Fidelity to the human disease
(
- Contribution to journal › Article
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Mark
Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model
(
- Contribution to journal › Article
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Mark
Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
(
- Contribution to journal › Article
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Mark
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease
(
- Contribution to journal › Article
- 2020
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Mark
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
(
- Contribution to journal › Article
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Mark
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
(
- Contribution to journal › Article
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Mark
Parkinson’s disease laterality : a 11C-PE2I PET imaging study
2020) In Journal of Neurology(
- Contribution to journal › Article
- 2019
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Mark
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease
(
- Contribution to journal › Article
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Mark
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS) : a new animal model of relevance to schizophrenia
(
- Contribution to journal › Article
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Mark
How is alpha-synuclein cleared from the cell?
(
- Contribution to journal › Scientific review
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Mark
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
(
- Contribution to journal › Article
- 2018
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Mark
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein
(
- Contribution to journal › Article
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Mark
Multivoxel 1H-MR Spectroscopy Biometrics for Preoprerative Differentiation Between Brain Tumors
(
- Contribution to journal › Article
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Mark
Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs
(
- Contribution to journal › Article
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Mark
Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay
(
- Contribution to journal › Article
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Mark
Pre- and postsynaptic dysregulation of dopamine signalling in Parkinson's disease
(
- Thesis › Doctoral thesis (compilation)
-
Mark
Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice
(
- Contribution to journal › Article
- 2017
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Mark
Toxic effects of human and rodent variants of alpha-synuclein in vivo
(
- Contribution to journal › Article
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Mark
Gene therapy for Parkinson's disease : Disease modification by GDNF family of ligands
(
- Contribution to journal › Scientific review
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Mark
Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats
(
- Contribution to journal › Article
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Mark
Multibiometric multivoxel mr spectroscopy for distinction between brain tumours
(
- Contribution to journal › Published meeting abstract
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Mark
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy : studies in rodents and nonhuman primates
(
- Contribution to journal › Article
- 2016
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Mark
Reduced baseline sensitivity to Maraviroc inhibition among R5 HIV-1 isolates from individuals with severe immunodeficiency.
(
- Contribution to journal › Letter
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Mark
Neurochemical Signatures for the Evaluation of Disease State and Therapeutic Strategies in Neurodegenerative Diseases: a Magnetic Resonance Spectroscopy Study
2016)(
- Thesis › Doctoral thesis (compilation)
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Mark
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
(
- Contribution to journal › Article
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Mark
Pathogenic effects of alpha-synuclein: modifications and toxicity
2016)(
- Thesis › Doctoral thesis (compilation)
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Mark
Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.
(
- Contribution to journal › Article
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Mark
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?
(
- Contribution to journal › Scientific review
- 2015
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Mark
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.
(
- Contribution to journal › Article
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Mark
Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.
(
- Contribution to journal › Article
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Mark
The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.
(
- Contribution to journal › Article
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Mark
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
(
- Contribution to journal › Article
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Mark
Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
(
- Contribution to journal › Article
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Mark
Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study.
(
- Contribution to journal › Letter
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Mark
Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
(
- Contribution to journal › Article
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Mark
A doctor's dilemma
(
- Contribution to journal › Article
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Mark
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.
(
- Contribution to journal › Article
- 2014
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Mark
Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
(
- Contribution to journal › Article
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Mark
Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease
(
- Thesis › Doctoral thesis (compilation)
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Mark
Twisting mice move the dystonia field forward
(
- Contribution to journal › Debate/Note/Editorial
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Mark
Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease
(
- Contribution to journal › Article
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Mark
Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.
(
- Contribution to journal › Article
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Mark
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
(
- Contribution to journal › Article
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Mark
Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.
(
- Contribution to journal › Article
- 2013
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Mark
Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents
(
- Thesis › Doctoral thesis (compilation)
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Mark
The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats
(
- Contribution to journal › Article
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Mark
Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration
(
- Contribution to journal › Article
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Mark
Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
(
- Contribution to journal › Article
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Mark
Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.
(
- Contribution to journal › Article
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Mark
Variability in Neuronal Expression of Dopamine Receptors and Transporters in the Substantia Nigra
(
- Contribution to journal › Article
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Mark
Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
(
- Contribution to journal › Article
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Mark
Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies
(
- Contribution to journal › Scientific review
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Mark
Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein
(
- Contribution to journal › Article
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Mark
Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents.
(
- Contribution to journal › Article
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Mark
LAMP2A as a therapeutic target in Parkinson disease
(
- Contribution to journal › Debate/Note/Editorial
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Mark
Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
(
- Contribution to journal › Article
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Mark
Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntingtons disease
(
- Contribution to journal › Article
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Mark
Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry
(
- Contribution to journal › Article
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Mark
A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.
(
- Contribution to journal › Article
- 2012
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Mark
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
(
- Contribution to journal › Article
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Mark
Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.
(
- Contribution to journal › Article
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Mark
Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
(
- Contribution to journal › Article
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Mark
Special Issue: Viral delivery of genes: new frontiers Introduction
(
- Contribution to journal › Debate/Note/Editorial
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Mark
GIRK2 Expression in Dopamine Neurons of the Substantia Nigra and Ventral Tegmental Area
(
- Contribution to journal › Article
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Mark
Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
(
- Contribution to journal › Article
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Mark
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.
(
- Contribution to journal › Article
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Mark
Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain
(
- Contribution to journal › Scientific review
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Mark
alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
(
- Contribution to journal › Article
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Mark
Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
(
- Contribution to journal › Article
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Mark
Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease.
(
- Contribution to journal › Article
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Mark
Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
(
- Contribution to journal › Article
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Mark
Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue.
2012) In Journal of Neurochemistry(
- Contribution to journal › Article
- 2011
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Mark
Imaging of Brain Prion Protein Amyloid in Patients with Gertstmann-Straussler-Scheinker Disease
(
- Contribution to journal › Debate/Note/Editorial
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Mark
Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.
(
- Contribution to journal › Article
-
Mark
Systemic Rotenone Does Not Enhance Parkinsonian Pathology Caused By Intracerebral Alpha-Synuclein In Rats
(
- Contribution to journal › Published meeting abstract
-
Mark
GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
(
- Contribution to journal › Article
-
Mark
Magnetic Resonance Spectroscopic Methods for the Assessment of Metabolic Functions in the Diseased Brain.
2011) In Current Topics in Behavioral Neurosciences(
- Contribution to journal › Article
-
Mark
Gene therapy for Parkinson's disease shows promise.
(
- Contribution to journal › Article
-
Mark
Statistically Guided Visualization and Exploratory Analysis of Omics Data
2011)(
- Thesis › Doctoral thesis (compilation)
-
Mark
Efficacy of L-DOPA therapy in Parkinson's disease
2011) p.454-463(
- Chapter in Book/Report/Conference proceeding › Book chapter
- 2010
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Mark
Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats
(
- Contribution to journal › Article