Hakon Leffler

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2025
Mark Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Purić, Edvin ; Hassan, Mujtaba ^LU ; Sjövall, Fredrik ^LU ; Tomašič, Tihomir ; Pevec, Mojca ; Lah, Jurij ; Forteza, Jaume Adrover ^LU ; Sundin, Anders ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU , et al. (2025) In Communications Chemistry 8(1).
- Contribution to journal › Article
Mark Spatial N-glycan rearrangement on α₅β₁ integrin nucleates galectin-3 oligomers to determine endocytic fate
Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Hamitouche, Ilyes ; Wunder, Christian ; Chambon, Valérie ; Valades-Cruz, Cesar A. ; Leconte, Ludovic ; Sarangi, Nirod Kumar ; Robinson, Jack and Bai, Siau-Kun , et al. (2025) In Nature Communications 16.
- Contribution to journal › Article
Mark Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors
Purić, Edvin ; Marinović, Marina ; Kojek, Zala ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Anderluh, Marko ^LU and Mravljak, Janez (2025) In Acta Pharmaceutica 75(2). p.273-282
- Contribution to journal › Article
Mark Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis
MacDonald, Ewan ; Forrester, Alison ; Valades-Cruz, Cesar A. ; Madsen, Thomas D. ^LU ; Hetmanski, Joseph H.R. ; Dransart, Estelle ; Ng, Yeap ; Godbole, Rashmi ; Shp, Ananthan Akhil and Leconte, Ludovic , et al. (2025) In Nature Cell Biology 27(3). p.449-463
- Contribution to journal › Article
Mark Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition
Dahlqvist, Alexander ^LU ; Go, Rob Marc ; Kishor, Chandan ; Leffler, Hakon ^LU ; Blanchard, Helen and Nilsson, Ulf J ^LU (2025) In RSC Chemical Biology 6(9). p.1437-1450
- Contribution to journal › Article
2024
Mark Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils
Karlsson, Veronika ; Stål, Ebba ; Stoopendahl, Emma ; Ivarsson, Anton ; Leffler, Hakon ^LU ; Lycke, Maria ; Sundqvist, Martina ; Sundfeldt, Karin ; Christenson, Karin and Bernson, Elin (2024) In Frontiers in Immunology 15.
- Contribution to journal › Article
Mark The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Comeglio, Paolo ; Guarnieri, Giulia ; Filippi, Sandra ; Cellai, Ilaria ; Acciai, Gabriele ; Holyer, Ian ; Zetterberg, Fredrik ; Leffler, Hakon ^LU ; Kahl-Knutson, Barbro ^LU and Sarchielli, Erica , et al. (2024) In Frontiers in Pharmacology 15.
- Contribution to journal › Article
Mark Exploration into Galectin-3 Driven Endocytosis and Lattices
Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Mani, Satish Kailasam ; Sampaio, Julio Lopes ; Bouidghaghen, Lydia ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Johannes, Ludger (2024) In Biomolecules 14(9).
- Contribution to journal › Article
Mark Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
MacKinnon, Alison C. ; Humphries, Duncan C. ; Herman, Kimberley ; Roper, James A. ; Holyer, Ian ; Mabbitt, Joseph ; Mills, Ross ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Pedersen, Anders , et al. (2024) In European Journal of Pharmacology 985.
- Contribution to journal › Article
Mark Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R. ; Peterson, Kristoffer ; Nilsson, Ulf J. ^LU ; Andréasson Dahlgren, Kajsa ; Diehl, Carl ; Hoyler, Ian ; Håkansson, Maria ; Khabut, Areej ^LU ; Kahl-Knutson, Barbro ^LU and Leffler, Hakon ^LU , et al. (2024) In Journal of Medicinal Chemistry 67(11). p.9374-9388
- Contribution to journal › Article

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