Mikael Akke
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- 2024
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Mark
Interplay of halogen bonding and solvation in protein-ligand binding
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- Contribution to journal › Article
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Mark
Ligand-induced protein transition state stabilization switches the binding pathway from conformational selection to induced fit
2024) In Proceedings of the National Academy of Sciences of the United States of America 121(14). p.2317747121-2317747121(
- Contribution to journal › Article
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Mark
Proton Transfer Kinetics in Histidine Side Chains Determined by pH-Dependent Multi-Nuclear NMR Relaxation
(
- Contribution to journal › Article
- 2023
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Mark
Cosolvent Dimethyl Sulfoxide Influences Protein-Ligand Binding Kinetics via Solvent Viscosity Effects : Revealing the Success Rate of Complex Formation Following Diffusive Protein-Ligand Encounter
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- Contribution to journal › Article
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Mark
Identification of Distinct Soluble States During Fibril Formation Using Multilinear Analysis of NMR Diffusion Data
(
- Chapter in Book/Report/Conference proceeding › Book chapter
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Mark
NMR Studies of Aromatic Ring Flips to Probe Conformational Fluctuations in Proteins
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- Contribution to journal › Scientific review
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Mark
Flexibility and Function of Distal Substrate-Binding Tryptophans in the Blue Mussel β-Mannanase MeMan5A and Their Role in Hydrolysis and Transglycosylation
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- Contribution to journal › Article
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Mark
Conformational Dynamics of Phytoglobin BvPgb1.2 from Beta vulgaris ssp. vulgaris
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- Contribution to journal › Article
- 2022
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Mark
Characterizing Fast Conformational Exchange of Aromatic Rings Using Residual Dipolar Couplings : Distinguishing Jumplike Flips from Other Exchange Mechanisms
(
- Contribution to journal › Article
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Mark
Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain : Effects on Domain Dynamics and Internal Flexibility
(
- Contribution to journal › Article
- 2021
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Mark
1H R1ρ relaxation dispersion experiments in aromatic side chains
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- Contribution to journal › Article
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Mark
Mapping the energy landscape of protein-ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion
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- Contribution to journal › Article
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Mark
Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C
(
- Contribution to journal › Article
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Mark
Transition-State Compressibility and Activation Volume of Transient Protein Conformational Fluctuations
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- Contribution to journal › Article
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Mark
Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R1ρ accordion experiments
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- Contribution to journal › Article
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Mark
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
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- Contribution to journal › Article
- 2020
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Mark
Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor
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- Contribution to journal › Article
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Mark
Accurate Backbone 13C and 15N Chemical Shift Tensors in Galectin-3 Determined by MAS NMR and QM/MM : Details of Structure and Environment Matter
(
- Contribution to journal › Article
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Mark
Ultrastructural evidence for self-replication of alzheimer-associated Aβ42 amyloid along the sides of fibrils
2020) In Proceedings of the National Academy of Sciences of the United States of America 117(21). p.11265-11273(
- Contribution to journal › Article
- 2019
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Mark
Stability and Local Unfolding of SOD1 in the Presence of Protein Crowders
(
- Contribution to journal › Article
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Mark
Backbone
1
H,
13
C, and
15
N resonance assignments of BoMan26A, a β-mannanase of the glycoside hydrolase family 26 from the human gut bacterium Bacteroides ovatus
(
- Contribution to journal › Article
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Mark
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
(
- Contribution to journal › Article
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Mark
Minute Additions of DMSO Affect Protein Dynamics Measurements by NMR Relaxation Experiments through Significant Changes in Solvent Viscosity
(
- Contribution to journal › Article
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Mark
Rotamer jumps, proton exchange, and amine inversion dynamics of dimethylated lysine residues in proteins resolved by ph-dependent 1h and 13c nmr relaxation dispersion
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- Contribution to journal › Article
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Mark
Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data
(
- Contribution to journal › Article
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Mark
Adsorption of unfolded Cu/Zn superoxide dismutase onto hydrophobic surfaces catalyzes its formation of amyloid fibrils
(
- Contribution to journal › Article
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Mark
Rapid NMR Relaxation Rate Measurements Using Optimal Non-Uniform Sampling of Multi-Dimensional Accordion Data Analyzed by a Sparse Reconstruction Method
2019) In The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory 123(27). p.5718-5723(
- Contribution to journal › Article
- 2018
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Mark
Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant
(
- Contribution to journal › Article
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Mark
Chemical Shifts of the Carbohydrate Binding Domain of Galectin-3 from Magic Angle Spinning NMR and Hybrid Quantum Mechanics/Molecular Mechanics Calculations
(
- Contribution to journal › Article
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Mark
Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design
(
- Contribution to journal › Article
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Mark
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
(
- Contribution to journal › Article
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Mark
Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations
(
- Contribution to journal › Article
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Mark
Designing interactions by control of protein-ligand complex conformation : Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
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- Contribution to journal › Article
- 2017
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Mark
Cu/Zn Superoxide Dismutase Forms Amyloid Fibrils under Near-Physiological Quiescent Conditions : The Roles of Disulfide Bonds and Effects of Denaturant
(
- Contribution to journal › Article
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Mark
Structural model of dodecameric heat-shock protein Hsp21 : Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity
(
- Contribution to journal › Article
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Mark
The Dynameomics Entropy Dictionary : A Large-Scale Assessment of Conformational Entropy across Protein Fold Space
(
- Contribution to journal › Article
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Mark
Dynamics of Aromatic Side Chains in the Active Site of FKBP12
(
- Contribution to journal › Article
- 2016
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Mark
Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements.
(
- Contribution to journal › Article
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Mark
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD
(
- Contribution to journal › Article
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Mark
A de Novo Designed Coiled-Coil Peptide with a Reversible pH-Induced Oligomerization Switch
(
- Contribution to journal › Article
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Mark
Structural analysis of a complex between small ubiquitin-like modifier 1 (SUMO1) and the ZZ domain of CREB-binding protein (CBP/p300) reveals a new interaction surface on SUMO
(
- Contribution to journal › Article
- 2015
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Mark
Site-Specific Protonation Kinetics of Acidic Side Chains in Proteins Determined by pH-Dependent Carboxyl (13)C NMR Relaxation.
(
- Contribution to journal › Article
- 2014
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Mark
Off-resonance rotating-frame relaxation dispersion experiment for (13)C in aromatic side chains using L-optimized TROSY-selection.
(
- Contribution to journal › Article
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Mark
Computational design of a leucine-rich repeat protein with a predefined geometry.
(
- Contribution to journal › Article
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Mark
Multidimensional Cramér-Rao Lower Bound for Non-uniformly Sampled NMR Signals
2014) 22nd European Signal Processing Conference - EUSIPCO 2014(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
Ring Flips Revisited: C-13 Relaxation Dispersion Measurements of Aromatic Side Chain Dynamics and Activation Barriers in Basic Pancreatic Trypsin Inhibitor
(
- Contribution to journal › Article
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Mark
Conformational Entropies and Order Parameters: Convergence, Reproducibility, and Transferability
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- Contribution to journal › Article
- 2013
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Mark
Protein conformational exchange measured by (1)H R 1ρ relaxation dispersion of methyl groups.
(
- Contribution to journal › Article
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Mark
Slow Aromatic Ring Flips Detected Despite Near-Degenerate NMR Frequencies of the Exchanging Nuclei.
(
- Contribution to journal › Article
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Mark
Local Unfolding and Aggregation Mechanisms of SOD1: A Monte Carlo Exploration.
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- Contribution to journal › Article
- 2012
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Mark
Specific (CD2CD2SCHD2)-C-12-D-beta-C-12-D-gamma-C-13-H-epsilon Isotopomer Labeling of Methionine To Characterize Protein Dynamics by H-1 and C-13 NMR Relaxation Dispersion
(
- Contribution to journal › Article
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Mark
Conformational dynamics and thermodynamics of protein-ligand binding studied by NMR relaxation.
(
- Contribution to journal › Article
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Mark
(13)C relaxation experiments for aromatic side chains employing longitudinal- and transverse-relaxation optimized NMR spectroscopy.
(
- Contribution to journal › Article
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Mark
The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
(
- Contribution to journal › Article
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Mark
Conformational exchange of aromatic side chains characterized by L-optimized TROSY-selected (13)C CPMG relaxation dispersion.
(
- Contribution to journal › Article
- 2011
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Mark
Protein loop compaction and the origin of the effect of arginine and glutamic acid mixtures on solubility, stability and transient oligomerization of proteins
(
- Contribution to journal › Article
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Mark
100% complete assignment of non-labile H-1, C-13, and N-15 signals for calcium-loaded calbindin D-9k P43G
(
- Contribution to journal › Article
- 2010
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Mark
Starting-Condition Dependence of Order Parameters Derived from Molecular Dynamics Simulations
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- Contribution to journal › Article
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Mark
Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3.
(
- Contribution to journal › Article
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Mark
Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution.
(
- Contribution to journal › Article
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Mark
pK(a) Values for the Unfolded State under Native Conditions Explain the pH-Dependent Stability of PGB1.
(
- Contribution to journal › Article
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Mark
Structure and Dynamics of Ribosomal Protein L12: An Ensemble Model Based on SAXS and NMR Relaxation
(
- Contribution to journal › Article
- 2009
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Mark
Differential responses of the backbone and side-chain conformational dynamics in FKBP12 upon binding the transition-state analog FK506: implications for transition-state stabilization and target protein recognition.
(
- Contribution to journal › Article
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Mark
Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization.
(
- Contribution to journal › Article
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Mark
Conformational entropy changes upon lactose binding to the carbohydrate recognition domain of galectin-3.
(
- Contribution to journal › Article
- 2008
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Mark
Multiple-Timescale Dynamics of Side-Chain Carboxyl and Carbonyl Groups in Proteins by C-13 Nuclear Spin Relaxation
(
- Contribution to journal › Article
- 2007
-
Mark
Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Ca and side-chain methyl positions in protein
(
- Contribution to journal › Article
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Mark
Structural characterization of the ribosomal P1A-P2B protein dimer by small-angle X-ray scattering and NMR spectroscopy
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- Contribution to journal › Article
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Mark
The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G and RF3 via a conserved region of the L12 C-terminal domain
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- Contribution to journal › Article
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Mark
Characterization of Chemical Exchange Using Residual Dipolar Coupling
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- Contribution to journal › Article
- 2006
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Mark
The inverted chevron plot measured by NMR relaxation reveals a native-like unfolding intermediate in acyl-CoA binding protein
(
- Contribution to journal › Article
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Mark
Biosynthetic 13C labeling of aromatic side-chains in proteins for NMR relaxation measurements
(
- Contribution to journal › Article
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Mark
Functional dynamics of human FKBP12 revealed by methyl C-13 rotating frame relaxation dispersion NMR spectroscopy
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- Contribution to journal › Article
- 2005
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Mark
Correlated dynamics of consecutive residues reveal transient and cooperative unfolding of secondary structure in proteins
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- Contribution to journal › Article
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Mark
Off-resonance rotating-frame amide proton spin relaxation experiments measuring microsecond chemical exchange in proteins
(
- Contribution to journal › Article
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Mark
Microsecond protein dynamics measured by C-13(alpha) rotating-frame spin relaxation
(
- Contribution to journal › Article
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Mark
Compact oleic acid in HAMLET.
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- Contribution to journal › Article
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Mark
Unfolding and inactivation of cutinases by AOT and guanidine hydrochloride
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- Contribution to journal › Article
- 2004
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Mark
Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein
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- Contribution to journal › Article
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Mark
Conformation and dynamics of ribosomal stalk protein L12 in solution and on the ribosome
(
- Contribution to journal › Article
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Mark
Letter to the Editor: Sequential H-1, N-15 and C-13 NMR assignment of human calbindin D28k
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- Contribution to journal › Article
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Mark
Out of hot water
(
- Contribution to journal › Letter
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Mark
Quantitative analysis of conformational exchange contributions to H-1-N-15 multiple-quantum relaxation using field-dependent measurements. Time scale and structural characterization of exchange in a calmodulin C-terminal domain mutant
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- Contribution to journal › Article
- 2003
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Mark
Carbonyl 13C Transverse Relaxation Measurements to Sample Protein Backbone Dynamics.
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- Contribution to journal › Article
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Mark
A statistical analysis of NMR spectrometer noise.
(
- Contribution to journal › Article
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Mark
Combined use of NMR relaxation measurements and hydrodynamic calculations to study protein association. Evidence for tetramers of low molecular weight protein tyrosine phosphatase in solution
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- Contribution to journal › Article
- 2002
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Mark
Calbindin D28k exhibits properties characteristic of a Ca2+ sensor.
(
- Contribution to journal › Article
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Mark
NMR methods for characterizing microsecond to millisecond dynamics in recognition and catalysis
(
- Contribution to journal › Scientific review
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Mark
Intramolecular dynamics of low molecular weight protein tyrosine phosphatase in monomer-dimer equilibrium studied by NMR: A model for changes in dynamics upon target binding
(
- Contribution to journal › Article
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Mark
Enzyme dynamics during catalysis
(
- Contribution to journal › Article
- 2001
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Mark
An open and shut case
(
- Contribution to journal › Letter
- 1999
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Mark
From Snapshot to Movie: φ Analysis of Protein Folding Transition States Taken One Step Further
(
- Contribution to journal › Article
- 1998
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Mark
Sequence and context dependence of EF-hand loop dynamics. An 15N relaxation study of a calcium-binding site mutant of calbindin D(9k)
(
- Contribution to journal › Article