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- 2024
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Mark
Endocytic Roles of Glycans on Proteins and Lipids
(
- Contribution to journal › Article
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Mark
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket
(
- Contribution to journal › Article
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Mark
Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
(
- Contribution to journal › Article
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Mark
Interplay of halogen bonding and solvation in protein-ligand binding
(
- Contribution to journal › Article
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Mark
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
2024) In Journal of Medicinal Chemistry(
- Contribution to journal › Article
- 2023
-
Mark
Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds
(
- Contribution to journal › Article
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Mark
Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
(
- Contribution to journal › Article
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Mark
Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
(
- Contribution to journal › Article
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Mark
Discovery of Selective and Orally Available Galectin-1 Inhibitors
(
- Contribution to journal › Article
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Mark
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
(
- Contribution to journal › Article
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Mark
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
(
- Contribution to journal › Article
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Mark
Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts
(
- Contribution to journal › Article
-
Mark
Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1
(
- Contribution to journal › Article
- 2022
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Mark
Site-specific N-glycan profiles of α5β1 integrin from rat liver
(
- Contribution to journal › Article
-
Mark
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors
(
- Contribution to journal › Article
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Mark
Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
(
- Contribution to journal › Article
-
Mark
Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside
(
- Contribution to journal › Article
-
Mark
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix
(
- Contribution to journal › Article
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Mark
Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins
(
- Contribution to journal › Article
-
Mark
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia
(
- Contribution to journal › Article
-
Mark
Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB
(
- Contribution to journal › Article
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Mark
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
(
- Contribution to journal › Article
-
Mark
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
(
- Contribution to journal › Article
- 2021
-
Mark
Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors
(
- Contribution to journal › Article
-
Mark
Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals
(
- Contribution to journal › Article
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Mark
Structure-Guided Design of d -Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain
(
- Contribution to journal › Article
-
Mark
Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C
(
- Contribution to journal › Article
-
Mark
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression
(
- Contribution to journal › Article
-
Mark
Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain : Structure-based design and optimisation
(
- Contribution to journal › Article
-
Mark
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
(
- Contribution to journal › Article
-
Mark
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
(
- Contribution to journal › Article
- 2020
-
Mark
Epimers Switch Galectin-9 Domain Selectivity : 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal
(
- Contribution to journal › Article
-
Mark
In Vivo Veritas : 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
(
- Contribution to journal › Article
- 2019
-
Mark
Letter by Leffler Regarding Article, "Modified Citrus Pectin Prevents Blood-Brain Barrier Disruption in Mouse Subarachnoid Hemorrhage by Inhibiting Galectin-3"
(
- Contribution to journal › Letter
-
Mark
C1-Galactopyranosyl Heterocycle Structure Guides Selectivity : Triazoles Prefer Galectin-1 and Oxazoles Prefer Galectin-3
(
- Contribution to journal › Article
-
Mark
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
A galactoside-binding protein tricked into binding unnatural pyranose derivatives : 3-deoxy-3-methyl-gulosides selectively inhibit galectin-1
(
- Contribution to journal › Article
-
Mark
Stereo- And regioselective hydroboration of 1-exo-methylene pyranoses : Discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors
(
- Contribution to journal › Article
-
Mark
Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
(
- Contribution to journal › Article
-
Mark
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
(
- Contribution to journal › Article
-
Mark
Structure and Energetics of Ligand–Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides : Insight into Solvation Effects and Multipolar Interactions
(
- Contribution to journal › Article
-
Mark
Extracellular and intracellular small-molecule galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
(
- Contribution to journal › Article
-
Mark
An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade
(
- Contribution to journal › Article
-
Mark
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
(
- Contribution to journal › Article
- 2018
-
Mark
Galectins at a glance
(
- Contribution to journal › Article
-
Mark
Different angioregulatory activity of monovalent galectin-9 isoforms
(
- Contribution to journal › Article
-
Mark
Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function
(
- Contribution to journal › Article
-
Mark
Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions
(
- Contribution to journal › Article
-
Mark
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
(
- Contribution to journal › Article
-
Mark
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
(
- Contribution to journal › Article
-
Mark
The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
(
- Contribution to journal › Article
-
Mark
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
(
- Contribution to journal › Article
-
Mark
Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
(
- Contribution to journal › Article
- 2017
-
Mark
Galectin-3 inhibition by a small-molecule inhibitor reduces both pathological corneal neovascularization and fibrosis
(
- Contribution to journal › Article
-
Mark
Spindle pole cohesion requires glycosylation-mediated localization of NuMA
(
- Contribution to journal › Article
- 2016
-
Mark
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3 '-sulfo-lactose, and 2 '-fucosyllactose
(
- Contribution to journal › Article
-
Mark
Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis.
(
- Contribution to journal › Article
-
Mark
Galactose-amidine derivatives as selective antagonists of galectin-9
(
- Contribution to journal › Article
-
Mark
A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model
(
- Contribution to journal › Article
-
Mark
Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans
(
- Contribution to journal › Article
-
Mark
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
(
- Contribution to journal › Article
-
Mark
Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C
(
- Contribution to journal › Article
-
Mark
Intra- and inter-molecular interactions of human galectin-3: assessment by full-assignment-based NMR.
(
- Contribution to journal › Article
-
Mark
Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition
(
- Contribution to journal › Article
- 2015
-
Mark
Structural characterization of human galectin-4 C-terminal domain : Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens
(
- Contribution to journal › Article
-
Mark
Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury
(
- Contribution to journal › Article
-
Mark
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
(
- Contribution to journal › Article
- 2014
-
Mark
Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists
(
- Contribution to journal › Article
-
Mark
Ligand binding and complex formation of galectin-3 is modulated by pH variations
(
- Contribution to journal › Article
-
Mark
Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins
(
- Contribution to journal › Article
-
Mark
Design, synthesis, And applications of galectin modulators in human health
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
The role of Galectin-3 in α-synuclein-induced microglial activation
(
- Contribution to journal › Scientific review
-
Mark
Primary and secondary glomerulonephritides 1.
2014) In Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 29 Suppl 3(May). p.186-200(
- Contribution to journal › Article
- 2013
-
Mark
Galectin-3 guides intracellular trafficking of some human serotransferrin glycoforms
(
- Contribution to journal › Article
-
Mark
Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1
(
- Contribution to journal › Article
-
Mark
Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro
(
- Contribution to journal › Article
-
Mark
Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors
(
- Contribution to journal › Article
- 2012
-
Mark
Low-Molecular Weight Inhibitors of Galectins
(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
-
Mark
Ligand induced galectin-3 self-association.
(
- Contribution to journal › Article
-
Mark
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual
(
- Contribution to journal › Article
-
Mark
Taloside Inhibitors of Galectin-1 and Galectin-3
(
- Contribution to journal › Article
-
Mark
Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types.
(
- Contribution to journal › Article
-
Mark
Inhibition mechanism of human galectin-7 by a novel galactose- benzylphosphate inhibitor
(
- Contribution to journal › Article
-
Mark
Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins.
(
- Contribution to journal › Article
-
Mark
Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice
(
- Contribution to journal › Article
-
Mark
Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy subjects.
(
- Contribution to journal › Article
-
Mark
The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
(
- Contribution to journal › Article
-
Mark
Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease.
(
- Contribution to journal › Article
-
Mark
Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3
(
- Contribution to journal › Article
- 2011
-
Mark
Inhibition of Galectins with Small Molecules
(
- Contribution to journal › Article
-
Mark
Synthesis of 3-amido-3-deoxy-beta-D-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors
(
- Contribution to journal › Article
-
Mark
Arene-anion based arginine-binding motif on a galactose scaffold : Structure-activity relationships of interactions with arginine-rich galectins
(
- Contribution to journal › Article
-
Mark
The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins
(
- Contribution to journal › Article
-
Mark
Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.
(
- Contribution to journal › Article
- 2010
-
Mark
Copper-free huisgen 1,3-dipolar cycloaddition to 3-benzotriazolo-3-deoxy-β-D-galactopyranoside : Cyclization of a galactopyranoside azide and benzyne
(
- Contribution to journal › Article
-
Mark
1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
The inflammatory mediator galectin-3 is bound to phagocytes in circulation
(
- Contribution to journal › Published meeting abstract
-
Mark
Essential role of galectin3 in reducing the severity of S. aureus-induced arthritis in mice
(
- Contribution to journal › Published meeting abstract
-
Mark
Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3.
(
- Contribution to journal › Article