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- 2024
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Mark
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket
(
- Contribution to journal › Article
-
Mark
Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
(
- Contribution to journal › Article
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Mark
Interplay of halogen bonding and solvation in protein-ligand binding
(
- Contribution to journal › Article
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Mark
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
2024) In Journal of Medicinal Chemistry(
- Contribution to journal › Article
- 2023
-
Mark
Discovery of Selective and Orally Available Galectin-1 Inhibitors
(
- Contribution to journal › Article
-
Mark
Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
(
- Contribution to journal › Article
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Mark
Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds
(
- Contribution to journal › Article
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Mark
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
(
- Contribution to journal › Article
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Mark
Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
(
- Contribution to journal › Article
-
Mark
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
(
- Contribution to journal › Article
- 2022
-
Mark
Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside
(
- Contribution to journal › Article
-
Mark
Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
(
- Contribution to journal › Article
-
Mark
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix
(
- Contribution to journal › Article
-
Mark
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors
(
- Contribution to journal › Article
-
Mark
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia
(
- Contribution to journal › Article
-
Mark
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
(
- Contribution to journal › Article
-
Mark
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
(
- Contribution to journal › Article
- 2021
-
Mark
Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors
(
- Contribution to journal › Article
-
Mark
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
(
- Contribution to journal › Article
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Mark
Structure-Guided Design of d -Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain
(
- Contribution to journal › Article
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Mark
Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain : Structure-based design and optimisation
(
- Contribution to journal › Article
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Mark
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression
(
- Contribution to journal › Article
-
Mark
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
(
- Contribution to journal › Article
-
Mark
Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C
(
- Contribution to journal › Article
-
Mark
Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals
(
- Contribution to journal › Article
- 2020
-
Mark
Epimers Switch Galectin-9 Domain Selectivity : 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal
(
- Contribution to journal › Article
-
Mark
In Vivo Veritas : 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
(
- Contribution to journal › Article
- 2019
-
Mark
Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
(
- Contribution to journal › Article
-
Mark
An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade
(
- Contribution to journal › Article
-
Mark
Extracellular and intracellular small-molecule galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
Human trophoblast requires galectin-3 for cell migration and invasion
(
- Contribution to journal › Article
-
Mark
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
(
- Contribution to journal › Article
-
Mark
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
(
- Contribution to journal › Article
-
Mark
C1-Galactopyranosyl Heterocycle Structure Guides Selectivity : Triazoles Prefer Galectin-1 and Oxazoles Prefer Galectin-3
(
- Contribution to journal › Article
-
Mark
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
(
- Contribution to journal › Article
-
Mark
Structure and Energetics of Ligand–Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides : Insight into Solvation Effects and Multipolar Interactions
(
- Contribution to journal › Article
-
Mark
A galactoside-binding protein tricked into binding unnatural pyranose derivatives : 3-deoxy-3-methyl-gulosides selectively inhibit galectin-1
(
- Contribution to journal › Article
-
Mark
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
Stereo- And regioselective hydroboration of 1-exo-methylene pyranoses : Discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors
(
- Contribution to journal › Article
- 2018
-
Mark
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
(
- Contribution to journal › Article
-
Mark
Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
(
- Contribution to journal › Article
-
Mark
Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function
(
- Contribution to journal › Article
-
Mark
Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions
(
- Contribution to journal › Article
-
Mark
Designing interactions by control of protein-ligand complex conformation : Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
(
- Contribution to journal › Article
-
Mark
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
(
- Contribution to journal › Article
-
Mark
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
(
- Contribution to journal › Article
- 2017
-
Mark
Spindle pole cohesion requires glycosylation-mediated localization of NuMA
(
- Contribution to journal › Article
-
Mark
Galectin-3 inhibition by a small-molecule inhibitor reduces both pathological corneal neovascularization and fibrosis
(
- Contribution to journal › Article
- 2016
-
Mark
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3 '-sulfo-lactose, and 2 '-fucosyllactose
(
- Contribution to journal › Article
-
Mark
Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C
(
- Contribution to journal › Article
-
Mark
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
(
- Contribution to journal › Article
-
Mark
A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model
(
- Contribution to journal › Article
-
Mark
Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition
(
- Contribution to journal › Article
-
Mark
Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans
(
- Contribution to journal › Article
- 2015
-
Mark
Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury
(
- Contribution to journal › Article
-
Mark
Structural characterization of human galectin-4 C-terminal domain : Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens
(
- Contribution to journal › Article
- 2014
-
Mark
Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins
(
- Contribution to journal › Article
-
Mark
Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists
(
- Contribution to journal › Article
-
Mark
Design, synthesis, And applications of galectin modulators in human health
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
The role of Galectin-3 in α-synuclein-induced microglial activation
(
- Contribution to journal › Scientific review
-
Mark
Ligand binding and complex formation of galectin-3 is modulated by pH variations
(
- Contribution to journal › Article
- 2013
-
Mark
Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1
(
- Contribution to journal › Article
-
Mark
Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors
(
- Contribution to journal › Article
-
Mark
Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro
(
- Contribution to journal › Article
- 2012
-
Mark
Low-Molecular Weight Inhibitors of Galectins
(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
-
Mark
Ligand induced galectin-3 self-association.
(
- Contribution to journal › Article
-
Mark
The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
(
- Contribution to journal › Article
-
Mark
Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3
(
- Contribution to journal › Article
-
Mark
Inhibition mechanism of human galectin-7 by a novel galactose- benzylphosphate inhibitor
(
- Contribution to journal › Article
-
Mark
Taloside Inhibitors of Galectin-1 and Galectin-3
(
- Contribution to journal › Article
-
Mark
Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types.
(
- Contribution to journal › Article
- 2011
-
Mark
Synthesis of 3-amido-3-deoxy-beta-D-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors
(
- Contribution to journal › Article
-
Mark
Inhibition of Galectins with Small Molecules
(
- Contribution to journal › Article
-
Mark
The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins
(
- Contribution to journal › Article
-
Mark
Arene-anion based arginine-binding motif on a galactose scaffold : Structure-activity relationships of interactions with arginine-rich galectins
(
- Contribution to journal › Article
- 2010
-
Mark
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
(
- Contribution to journal › Article
-
Mark
Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3.
(
- Contribution to journal › Article
-
Mark
Mutational tuning of galectin-3 specificity and biological function.
(
- Contribution to journal › Article
-
Mark
The inflammatory mediator galectin-3 is bound to phagocytes in circulation
(
- Contribution to journal › Published meeting abstract
-
Mark
1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
Monovalent Interactions of Galectin-1
(
- Contribution to journal › Article
-
Mark
Multimeric Lactoside "Click Clusters" as Tools to Investigate the Effect of Linker Length in Specific Interactions with Peanut Lectin, Galectin-1, and-3
(
- Contribution to journal › Article
-
Mark
Copper-free huisgen 1,3-dipolar cycloaddition to 3-benzotriazolo-3-deoxy-β-D-galactopyranoside : Cyclization of a galactopyranoside azide and benzyne
(
- Contribution to journal › Article
- 2009
-
Mark
Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3.
(
- Contribution to journal › Article
-
Mark
Synthesis and Evaluation of New Thiodigalactoside-Based Chemical Probes to Label Galectin-3
(
- Contribution to journal › Article
-
Mark
Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer
(
- Contribution to journal › Article
- 2008
-
Mark
Regulation of alternative macrophage activation by galectin-3
(
- Contribution to journal › Article
-
Mark
Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins.
(
- Contribution to journal › Article
-
Mark
Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors.
(
- Contribution to journal › Article
-
Mark
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.
(
- Contribution to journal › Article
-
Mark
Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido-Thiodigalactosides.
(
- Contribution to journal › Article
-
Mark
Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.
(
- Contribution to journal › Article
-
Mark
Small-Molecule Galectin Inhibitors
(
- Contribution to journal › Scientific review
- 2007
-
Mark
Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors.
(
- Contribution to journal › Article
-
Mark
Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters
(
- Contribution to journal › Article
-
Mark
Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface.
(
- Contribution to journal › Article
- 2006
-
Mark
Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition.
(
- Contribution to journal › Article
-
Mark
Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors
(
- Contribution to journal › Article
-
Mark
Cobalt-mediated solid phase synthesis of 3-O-alkynylbenzyl galactosides and their evaluation as galectin inhibitors
(
- Contribution to journal › Article
-
Mark
Synthesis of a 3'-naphthamido-LacNAc fluorescein conjugate with high selectivity and affinity for galectin-3.
(
- Contribution to journal › Article