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Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros, Raul ; Lujan-Barroso, Leila ; Achaintre, David ; Franceschi, Silvia ; Kyrø, Cecilie ; Overvad, Kim ; Tjønneland, Anne ; Truong, Therese ; Lecuyer, Lucie and Boutron-Ruault, Marie Christine , et al. (2021) In American Journal of Clinical Nutrition 113(1). p.162-171
Abstract

Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted... (More)

Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, EPIC, Nested case–control study, Polyphenol, Thyroid cancer
in
American Journal of Clinical Nutrition
volume
113
issue
1
pages
10 pages
publisher
Oxford University Press
external identifiers
  • scopus:85100292857
  • pmid:33021645
ISSN
0002-9165
DOI
10.1093/ajcn/nqaa277
language
English
LU publication?
no
id
02f35986-8a84-4bc2-9b73-86139bbb9e3e
date added to LUP
2021-02-15 13:12:15
date last changed
2021-06-08 04:58:29
@article{02f35986-8a84-4bc2-9b73-86139bbb9e3e,
  abstract     = {<p>Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (OR<sub>log2</sub>: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (OR<sub>log2</sub>: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (OR<sub>log2</sub>: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.</p>},
  author       = {Zamora-Ros, Raul and Lujan-Barroso, Leila and Achaintre, David and Franceschi, Silvia and Kyrø, Cecilie and Overvad, Kim and Tjønneland, Anne and Truong, Therese and Lecuyer, Lucie and Boutron-Ruault, Marie Christine and Katzke, Verena and Johnson, Theron S. and Schulze, Matthias B. and Trichopoulou, Antonia and Peppa, Eleni and La Vechia, Carlo and Masala, Giovanna and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Ricceri, Fulvio and Skeie, Guri and Ramón Quirós, J. and Rodriguez-Barranco, Miguel and Amiano, Pilar and Chirlaque, María Dolores and Ardanaz, Eva and Almquist, Martin and Hennings, Joakim and Vermeulen, Roel and Wareham, Nicholas J. and Tong, Tammy Y.N. and Aune, Dagfinn and Byrnes, Graham and Weiderpass, Elisabete and Scalbert, Augustin and Rinaldi, Sabina and Agudo, Antonio},
  issn         = {0002-9165},
  language     = {eng},
  number       = {1},
  pages        = {162--171},
  publisher    = {Oxford University Press},
  series       = {American Journal of Clinical Nutrition},
  title        = {Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.1093/ajcn/nqaa277},
  doi          = {10.1093/ajcn/nqaa277},
  volume       = {113},
  year         = {2021},
}