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Plasma carotenoids as biomarkers of intake of fruits and vegetables: ecological-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Al-Delaimy, WK; Slimani, N; Ferrari, P; Key, T; Spencer, E; Johansson, I; Johansson, G; Mattisson, Iréne LU ; Wirfält, Elisabet LU and Sieri, S, et al. (2005) In European Journal of Clinical Nutrition 59(12). p.1397-1408
Abstract
Objective: The aim of this study was to assess the ability of a single 24-h dietary recall (24HDR) and food questionnaires (FQ) to predict plasma carotenoid levels at the ecological level by assessing the relationship between mean plasma carotenoid levels and mean intake of fruit and vegetables measured by 24HDR and FQ across 16 European regions. Design: A random subsample of 3089 subjects was included, stratified by age and gender. They provided blood samples and dietary information between 1992 and 2000 as part of the European Prospective Investigation into Cancer and Nutrition. Results: Using Spearman's correlation coefficients, the correlations between mean regional 24HDR fruit and vegetable variables and corresponding mean plasma... (More)
Objective: The aim of this study was to assess the ability of a single 24-h dietary recall (24HDR) and food questionnaires (FQ) to predict plasma carotenoid levels at the ecological level by assessing the relationship between mean plasma carotenoid levels and mean intake of fruit and vegetables measured by 24HDR and FQ across 16 European regions. Design: A random subsample of 3089 subjects was included, stratified by age and gender. They provided blood samples and dietary information between 1992 and 2000 as part of the European Prospective Investigation into Cancer and Nutrition. Results: Using Spearman's correlation coefficients, the correlations between mean regional 24HDR fruit and vegetable variables and corresponding mean plasma carotenoid levels were generally higher than the correlations using FQ means. The highest correlation was between the 24HDR citrus fruit variable and beta-cryptoxanthin (r = 0.90). For 24HDR, total fruits and vegetables were highly correlated with lutein, zeaxanthin, and beta-cryptoxanthin (r = 0.83-0.87), while vegetables were more closely related with lutein (r = 0.69) and zeaxanthin (r = 0.68), and fruits correlated with zeaxanthin (r = 0.87) and beta-cryptoxanthin (r = 0.84). Root vegetables (r = 0.81) and total carrots (r = 0.71) were well correlated with alpha-carotene. In the multivariate models adjusting for age, body mass index, and season, and using observations of means stratified by sex and region, the association was generally higher for 24HDR compared to FQ. Conclusion: Mean regional intakes of fruits and vegetables in several European countries were closely correlated with corresponding mean plasma levels of individual carotenoids. Fruits and vegetables measured by 24HDR were generally better able to predict plasma carotenoids at the ecological level. (Less)
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Contribution to journal
publication status
published
subject
keywords
fruits and vegetables, carotenoids, plasma, ecology, questionnaires, food frequency, 24-h dietary recall, EPIC
in
European Journal of Clinical Nutrition
volume
59
issue
12
pages
1397 - 1408
publisher
Nature Publishing Group
external identifiers
  • wos:000233658000008
  • pmid:16160701
  • scopus:31344471771
ISSN
1476-5640
DOI
10.1038/sj.ejcn.1602253
language
English
LU publication?
yes
id
c577050b-3c80-41b0-8f1b-b40aad2b5323 (old id 211713)
date added to LUP
2007-08-21 11:32:23
date last changed
2017-09-03 04:39:16
@article{c577050b-3c80-41b0-8f1b-b40aad2b5323,
  abstract     = {Objective: The aim of this study was to assess the ability of a single 24-h dietary recall (24HDR) and food questionnaires (FQ) to predict plasma carotenoid levels at the ecological level by assessing the relationship between mean plasma carotenoid levels and mean intake of fruit and vegetables measured by 24HDR and FQ across 16 European regions. Design: A random subsample of 3089 subjects was included, stratified by age and gender. They provided blood samples and dietary information between 1992 and 2000 as part of the European Prospective Investigation into Cancer and Nutrition. Results: Using Spearman's correlation coefficients, the correlations between mean regional 24HDR fruit and vegetable variables and corresponding mean plasma carotenoid levels were generally higher than the correlations using FQ means. The highest correlation was between the 24HDR citrus fruit variable and beta-cryptoxanthin (r = 0.90). For 24HDR, total fruits and vegetables were highly correlated with lutein, zeaxanthin, and beta-cryptoxanthin (r = 0.83-0.87), while vegetables were more closely related with lutein (r = 0.69) and zeaxanthin (r = 0.68), and fruits correlated with zeaxanthin (r = 0.87) and beta-cryptoxanthin (r = 0.84). Root vegetables (r = 0.81) and total carrots (r = 0.71) were well correlated with alpha-carotene. In the multivariate models adjusting for age, body mass index, and season, and using observations of means stratified by sex and region, the association was generally higher for 24HDR compared to FQ. Conclusion: Mean regional intakes of fruits and vegetables in several European countries were closely correlated with corresponding mean plasma levels of individual carotenoids. Fruits and vegetables measured by 24HDR were generally better able to predict plasma carotenoids at the ecological level.},
  author       = {Al-Delaimy, WK and Slimani, N and Ferrari, P and Key, T and Spencer, E and Johansson, I and Johansson, G and Mattisson, Iréne and Wirfält, Elisabet and Sieri, S and Agudo, A and Celentano, E and Palli, D and Sacerdote, C and Tumino, R and Dorronsoro, M and Ocke, MC and Bueno-De-Mesquita, HB and Overvad, K and Chirlaque, MD and Trichopoulou, A and Naska, A and Tjonneland, A and Olsen, A and Lund, E and Skeie, G and Ardanaz, E and Kesse, E and Boutron-Ruault, MC and Clavel-Chapelon, F and Bingham, S and Welch, AA and Martinez-Garcia, C and Nagel, G and Linseisen, J and Quiros, JR and Peeters, PHM and van Gils, CH and Boeing, H and van Kappel, AL and Steghens, JP and Riboli, E},
  issn         = {1476-5640},
  keyword      = {fruits and vegetables,carotenoids,plasma,ecology,questionnaires,food frequency,24-h dietary recall,EPIC},
  language     = {eng},
  number       = {12},
  pages        = {1397--1408},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Plasma carotenoids as biomarkers of intake of fruits and vegetables: ecological-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1602253},
  volume       = {59},
  year         = {2005},
}