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Anthropometric and metabolic improvements in human type 2 diabetes after introduction of an Okinawan-based Nordic diet are not associated with changes in microbial diversity or SCFA concentrations

Huang, Fang; Nilholm, Clara LU ; Roth, Bodil LU ; Linninge, Caroline LU ; Höglund, Peter LU ; Nyman, Margareta LU and Ohlsson, Bodil LU (2017) In International Journal of Food Sciences and Nutrition
Abstract

The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study mechanisms behind improvements by examining Enterobacteriaceae abundance, microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A secondary aim was exploring if metformin treatment affects microbiota or SCFAs. Thirty T2DM patients received the O-BN diet for 12 weeks. Faecal and blood samples were collected at baseline, 12 and 28 weeks. Although patients experienced weight loss and improved metabolic parameters, there were no significant changes in Enterobacteriaceae abundance or microbial diversity. Patients on metformin displayed higher Enterobacteriaceae... (More)

The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study mechanisms behind improvements by examining Enterobacteriaceae abundance, microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A secondary aim was exploring if metformin treatment affects microbiota or SCFAs. Thirty T2DM patients received the O-BN diet for 12 weeks. Faecal and blood samples were collected at baseline, 12 and 28 weeks. Although patients experienced weight loss and improved metabolic parameters, there were no significant changes in Enterobacteriaceae abundance or microbial diversity. Patients on metformin displayed higher Enterobacteriaceae abundance throughout the study (p = .008, p = .038, and p = .001, respectively). Isovaleric acid was decreased after 12 weeks (p = .018). Butyric acid was decreased at follow-up (p = .007). Improved anthropometry and metabolism in T2DM after introduction of the O-BN diet is not associated with changes in Enterobacteriaceae abundance, microbial diversity or SCFA concentrations.

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organization
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type
Contribution to journal
publication status
epub
subject
keywords
Enterobacteriaceae, microbial diversity, Okinawan-based Nordic diet, short-chain fatty acids (SCFA)
in
International Journal of Food Sciences and Nutrition
pages
12 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85036503576
ISSN
0963-7486
DOI
10.1080/09637486.2017.1408059
language
English
LU publication?
yes
id
29be7ad4-4676-41bd-8c43-f3f25a04e02e
date added to LUP
2017-12-18 08:37:18
date last changed
2018-01-07 12:28:59
@article{29be7ad4-4676-41bd-8c43-f3f25a04e02e,
  abstract     = {<p>The Okinawan-based Nordic (O-BN) diet improves anthropometry and metabolism in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to study mechanisms behind improvements by examining Enterobacteriaceae abundance, microbial diversity, and concentrations of short-chain fatty acids (SCFAs). A secondary aim was exploring if metformin treatment affects microbiota or SCFAs. Thirty T2DM patients received the O-BN diet for 12 weeks. Faecal and blood samples were collected at baseline, 12 and 28 weeks. Although patients experienced weight loss and improved metabolic parameters, there were no significant changes in Enterobacteriaceae abundance or microbial diversity. Patients on metformin displayed higher Enterobacteriaceae abundance throughout the study (p = .008, p = .038, and p = .001, respectively). Isovaleric acid was decreased after 12 weeks (p = .018). Butyric acid was decreased at follow-up (p = .007). Improved anthropometry and metabolism in T2DM after introduction of the O-BN diet is not associated with changes in Enterobacteriaceae abundance, microbial diversity or SCFA concentrations.</p>},
  author       = {Huang, Fang and Nilholm, Clara and Roth, Bodil and Linninge, Caroline and Höglund, Peter and Nyman, Margareta and Ohlsson, Bodil},
  issn         = {0963-7486},
  keyword      = {Enterobacteriaceae,microbial diversity,Okinawan-based Nordic diet,short-chain fatty acids (SCFA)},
  language     = {eng},
  month        = {12},
  pages        = {12},
  publisher    = {Taylor & Francis},
  series       = {International Journal of Food Sciences and Nutrition},
  title        = {Anthropometric and metabolic improvements in human type 2 diabetes after introduction of an Okinawan-based Nordic diet are not associated with changes in microbial diversity or SCFA concentrations},
  url          = {http://dx.doi.org/10.1080/09637486.2017.1408059},
  year         = {2017},
}