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Daily intake of milk powder and risk of celiac disease in early childhood : A nested case-control study

Hård af Segerstad, Elin M. LU ; Lee, Hye Seung; Aronsson, Carin Andrén LU ; Yang, Jimin; Uusitalo, Ulla; Sjöholm, Ingegerd LU ; Rayner, Marilyn LU ; Kurppa, Kalle; Virtanen, Suvi M. and Norris, Jill M., et al. (2018) In Nutrients 10(5).
Abstract

Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease. A 1-to-3 nested case-control study, comprised of 207 celiac disease children and 621 controls matched for sex, birth year, and HLA genotype, was performed on a birth cohort of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. Subjects were screened annually for celiac disease using tissue transglutaminase autoantibodies (tTGA). Three-day food records estimated the mean intake of milk powder at ages 6 months, 9 months, 12 months, 18 months, and... (More)

Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease. A 1-to-3 nested case-control study, comprised of 207 celiac disease children and 621 controls matched for sex, birth year, and HLA genotype, was performed on a birth cohort of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. Subjects were screened annually for celiac disease using tissue transglutaminase autoantibodies (tTGA). Three-day food records estimated the mean intake of milk powder at ages 6 months, 9 months, 12 months, 18 months, and 24 months. Conditional logistic regression calculated odds ratios (OR) at last intake prior to seroconversion of tTGA positivity, and for each time-point respectively and adjusted for having a first-degree relative with celiac disease and gluten intake. Intake of milk powder prior to seroconversion of tTGA positivity was not associated with celiac disease (OR = 1.00; 95% CI = 0.99, 1.03; p = 0.763). In conclusion, intake of milk powder in early childhood is not associated with celiac disease in genetically susceptible children.

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published
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keywords
Commercial infant foods, Formula, Gluten, HLA, Infant feeding, Milk powder, Sweden
in
Nutrients
volume
10
issue
5
publisher
MDPI AG
external identifiers
  • scopus:85046349002
ISSN
2072-6643
DOI
10.3390/nu10050550
language
English
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yes
id
abd9f341-f920-4e2d-a574-55f10f5b3f11
date added to LUP
2018-05-15 13:39:47
date last changed
2018-05-16 03:00:02
@article{abd9f341-f920-4e2d-a574-55f10f5b3f11,
  abstract     = {<p>Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease. A 1-to-3 nested case-control study, comprised of 207 celiac disease children and 621 controls matched for sex, birth year, and HLA genotype, was performed on a birth cohort of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. Subjects were screened annually for celiac disease using tissue transglutaminase autoantibodies (tTGA). Three-day food records estimated the mean intake of milk powder at ages 6 months, 9 months, 12 months, 18 months, and 24 months. Conditional logistic regression calculated odds ratios (OR) at last intake prior to seroconversion of tTGA positivity, and for each time-point respectively and adjusted for having a first-degree relative with celiac disease and gluten intake. Intake of milk powder prior to seroconversion of tTGA positivity was not associated with celiac disease (OR = 1.00; 95% CI = 0.99, 1.03; p = 0.763). In conclusion, intake of milk powder in early childhood is not associated with celiac disease in genetically susceptible children.</p>},
  articleno    = {550},
  author       = {Hård af Segerstad, Elin M. and Lee, Hye Seung and Aronsson, Carin Andrén and Yang, Jimin and Uusitalo, Ulla and Sjöholm, Ingegerd and Rayner, Marilyn and Kurppa, Kalle and Virtanen, Suvi M. and Norris, Jill M. and Agardh, Daniel and , },
  issn         = {2072-6643},
  keyword      = {Commercial infant foods,Formula,Gluten,HLA,Infant feeding,Milk powder,Sweden},
  language     = {eng},
  month        = {05},
  number       = {5},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Daily intake of milk powder and risk of celiac disease in early childhood : A nested case-control study},
  url          = {http://dx.doi.org/10.3390/nu10050550},
  volume       = {10},
  year         = {2018},
}