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- 2024
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Mark
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
2024) In Journal of Medicinal Chemistry(
- Contribution to journal › Article
-
Mark
Galectin-8 inhibition and functions in immune response and tumor biology
2024) In Medicinal Research Reviews(
- Contribution to journal › Scientific review
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Mark
Interplay of halogen bonding and solvation in protein-ligand binding
(
- Contribution to journal › Article
-
Mark
Development of a novel AAK1 inhibitor via Kinobeads-based screening
(
- Contribution to journal › Article
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Mark
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket
(
- Contribution to journal › Article
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Mark
Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
(
- Contribution to journal › Article
- 2023
-
Mark
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
(
- Contribution to journal › Article
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Mark
Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
(
- Contribution to journal › Article
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Mark
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
(
- Contribution to journal › Article
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Mark
Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds
(
- Contribution to journal › Article
-
Mark
Resistance to anti-PD-1/anti-PD-L1 : galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
(
- Contribution to journal › Article
-
Mark
Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
(
- Contribution to journal › Article
-
Mark
N-BAR and F-BAR proteins - Endophilin-A3 and PSTPIP1 - control clathrin-independent endocytosis of L1CAM
(
- Contribution to journal › Article
-
Mark
Discovery of Selective and Orally Available Galectin-1 Inhibitors
(
- Contribution to journal › Article
-
Mark
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis
(
- Contribution to journal › Article
- 2022
-
Mark
Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside
(
- Contribution to journal › Article
-
Mark
Sialic Acid 4-N-Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter
(
- Contribution to journal › Article
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Mark
Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
(
- Contribution to journal › Article
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Mark
Direct Sialic Acid 4-OAc Substitution by Nitrogen, Sulfur and Carbon Nucleophiles with Retention of Stereochemistry
(
- Contribution to journal › Article
-
Mark
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia
(
- Contribution to journal › Article
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Mark
Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth
(
- Contribution to journal › Article
-
Mark
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors
(
- Contribution to journal › Article
-
Mark
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
(
- Contribution to journal › Article
-
Mark
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix
(
- Contribution to journal › Article
-
Mark
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
(
- Contribution to journal › Article
- 2021
-
Mark
Coupling ofN-tosylhydrazones with tetrazoles : synthesis of 2-β-d-glycopyranosylmethyl-5-substituted-2H-tetrazole type glycomimetics
(
- Contribution to journal › Article
-
Mark
Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C
(
- Contribution to journal › Article
-
Mark
Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors
(
- Contribution to journal › Article
-
Mark
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression
(
- Contribution to journal › Article
-
Mark
Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity
(
- Contribution to journal › Article
-
Mark
Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals
(
- Contribution to journal › Article
-
Mark
Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain : Structure-based design and optimisation
(
- Contribution to journal › Article
-
Mark
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
(
- Contribution to journal › Article
-
Mark
Structure-Guided Design of d -Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain
(
- Contribution to journal › Article
-
Mark
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
(
- Contribution to journal › Article
- 2020
-
Mark
Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice
(
- Contribution to journal › Article
-
Mark
Epimers Switch Galectin-9 Domain Selectivity : 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal
(
- Contribution to journal › Article
-
Mark
The binding mechanism of the virulence factor Streptococcus suis adhesin P subtype to globotetraosylceramide is associated with systemic disease
(
- Contribution to journal › Article
-
Mark
Synthesis of tricyclic carbohydrate-benzene hybrids as selective inhibitors of galectin-1 and galectin-8 N-terminal domains
(
- Contribution to journal › Article
-
Mark
In Vivo Veritas : 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
(
- Contribution to journal › Article
- 2019
-
Mark
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
Extracellular and intracellular small-molecule galectin-3 inhibitors
(
- Contribution to journal › Article
-
Mark
Human trophoblast requires galectin-3 for cell migration and invasion
(
- Contribution to journal › Article
-
Mark
An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade
(
- Contribution to journal › Article
-
Mark
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
(
- Contribution to journal › Article
-
Mark
C1-Galactopyranosyl Heterocycle Structure Guides Selectivity : Triazoles Prefer Galectin-1 and Oxazoles Prefer Galectin-3
(
- Contribution to journal › Article
-
Mark
Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
(
- Contribution to journal › Article
-
Mark
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
(
- Contribution to journal › Article
-
Mark
Stereo- And regioselective hydroboration of 1-exo-methylene pyranoses : Discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors
(
- Contribution to journal › Article
-
Mark
A galactoside-binding protein tricked into binding unnatural pyranose derivatives : 3-deoxy-3-methyl-gulosides selectively inhibit galectin-1
(
- Contribution to journal › Article
-
Mark
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
(
- Contribution to journal › Article
-
Mark
Structure and Energetics of Ligand–Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides : Insight into Solvation Effects and Multipolar Interactions
(
- Contribution to journal › Article
- 2018
-
Mark
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
(
- Contribution to journal › Article
-
Mark
Arynes in the Monoarylation of Unprotected Carbohydrate Amines
(
- Contribution to journal › Article
-
Mark
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site
(
- Contribution to journal › Article
-
Mark
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain
(
- Contribution to journal › Article
-
Mark
Galectin-3 is an amplifier of the interleukin-1β-mediated inflammatory response in corneal keratinocytes
(
- Contribution to journal › Article
-
Mark
Designing interactions by control of protein-ligand complex conformation : Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
(
- Contribution to journal › Article
-
Mark
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity
(
- Contribution to journal › Article
-
Mark
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
(
- Contribution to journal › Article
-
Mark
Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function
(
- Contribution to journal › Article
-
Mark
Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions
(
- Contribution to journal › Article
-
Mark
Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations
(
- Contribution to journal › Article
-
Mark
Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
(
- Contribution to journal › Article
- 2017
-
Mark
Galectin-3 inhibition by a small-molecule inhibitor reduces both pathological corneal neovascularization and fibrosis
(
- Contribution to journal › Article
-
Mark
Spindle pole cohesion requires glycosylation-mediated localization of NuMA
(
- Contribution to journal › Article
- 2016
-
Mark
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3 '-sulfo-lactose, and 2 '-fucosyllactose
(
- Contribution to journal › Article
-
Mark
Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release.
(
- Contribution to journal › Article
-
Mark
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
(
- Contribution to journal › Article
-
Mark
A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model
(
- Contribution to journal › Article
-
Mark
Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C
(
- Contribution to journal › Article
-
Mark
Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition
(
- Contribution to journal › Article
-
Mark
Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents
(
- Contribution to journal › Article
-
Mark
Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans
(
- Contribution to journal › Article
- 2015
-
Mark
Aryl Sulfonates in Inversions at Secondary Carbohydrate Hydroxyl Groups: A New and Improved Route Toward 3-Azido-3-deoxy-beta-D-galactopyranosides
(
- Contribution to journal › Article
-
Mark
Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury
(
- Contribution to journal › Article
-
Mark
Structural characterization of human galectin-4 C-terminal domain : Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens
(
- Contribution to journal › Article
-
Mark
Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter
(
- Contribution to journal › Article
- 2014
-
Mark
Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins
(
- Contribution to journal › Article
-
Mark
Tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the synthesis of S-linked glycosides and glyco-conjugates.
(
- Contribution to journal › Article
-
Mark
Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists
(
- Contribution to journal › Article
-
Mark
Design, synthesis, And applications of galectin modulators in human health
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
The role of Galectin-3 in α-synuclein-induced microglial activation
(
- Contribution to journal › Scientific review
-
Mark
Ligand binding and complex formation of galectin-3 is modulated by pH variations
(
- Contribution to journal › Article
- 2013
-
Mark
Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors
(
- Contribution to journal › Article
-
Mark
Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1
(
- Contribution to journal › Article
-
Mark
Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro
(
- Contribution to journal › Article
-
Mark
Bacterial adhesion of Streptococcus suis to host cells and its inhibition by carbohydrate ligands
(
- Contribution to journal › Scientific review
- 2012
-
Mark
Low-Molecular Weight Inhibitors of Galectins
(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
-
Mark
The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
(
- Contribution to journal › Article
-
Mark
Ligand induced galectin-3 self-association.
(
- Contribution to journal › Article
-
Mark
Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types.
(
- Contribution to journal › Article
-
Mark
Taloside Inhibitors of Galectin-1 and Galectin-3
(
- Contribution to journal › Article
-
Mark
Inhibition mechanism of human galectin-7 by a novel galactose- benzylphosphate inhibitor
(
- Contribution to journal › Article
-
Mark
Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice
(
- Contribution to journal › Article
-
Mark
Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3
(
- Contribution to journal › Article
- 2011
-
Mark
Inhibition of Galectins with Small Molecules
(
- Contribution to journal › Article
-
Mark
Synthesis of 3-amido-3-deoxy-beta-D-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors
(
- Contribution to journal › Article
-
Mark
Identification of a Novel Streptococcal Adhesin P (SadP) Protein Recognizing Galactosyl-alpha 1-4-galactose-containing Glycoconjugates CONVERGENT EVOLUTION OF BACTERIAL PATHOGENS TO BINDING OF THE SAME HOST RECEPTOR
(
- Contribution to journal › Article
-
Mark
Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries
(
- Contribution to journal › Article