IPSC Laboratory for CNS Disease Modeling
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- 2023
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Mark
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer's disease pathogenesis
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- Contribution to journal › Article
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Mark
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function
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- Contribution to journal › Article
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Mark
Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections
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- Contribution to journal › Article
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Mark
Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration
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- Contribution to journal › Article
- 2022
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Mark
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties
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- Contribution to journal › Article
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Mark
Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes
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- Contribution to journal › Article
- 2021
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Mark
Generation of the human pluripotent stem-cell-derived astrocyte model with forebrain identity
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- Contribution to journal › Article
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Mark
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration
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- Contribution to journal › Article
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Mark
The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
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- Contribution to journal › Article
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Mark
Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome
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- Contribution to journal › Article
- 2020
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Mark
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes
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- Contribution to journal › Article
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Mark
Unique signatures of stress-induced senescent human astrocytes
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- Contribution to journal › Article
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Mark
Stem cell-based models to study cellular alterations in Parkinson’s Disease
2020) In Lund University, Faculty of Medicine Doctoral Dissertation Series(
- Thesis › Doctoral thesis (compilation)
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Mark
Human iPSC-Derived Hippocampal Spheroids : An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
(
- Contribution to journal › Article
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Mark
Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease
(
- Contribution to journal › Article
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Mark
Generation of an induced pluripotent stem cell line (CSC-32) from a patient with Parkinson's disease carrying a heterozygous variation p.A53T in the SNCA gene
(
- Contribution to journal › Article
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Mark
Oligodendroglial (dys)function in alpha-synucleinopathies
2020) In Lund University, Faculty of Medicine Doctoral Dissertation Series(
- Thesis › Doctoral thesis (compilation)
- 2019
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Mark
Generation of an induced pluripotent stem cell line (CSC-46) from a patient with Parkinson's disease carrying a novel p.R301C mutation in the GBA gene
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- Contribution to journal › Article
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Mark
PARK2 mutation causes metabolic disturbances and impaired survival of human iPSC-derived neurons
(
- Contribution to journal › Article
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Mark
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes
(
- Contribution to journal › Article
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Mark
Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
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- Contribution to journal › Article
- 2018
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Mark
Parkin absence accelerates microtubule aging in dopaminergic neurons
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- Contribution to journal › Article
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Mark
Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
2018) In Proceedings of the National Academy of Sciences of the United States of America 115(37). p.8765-8774(
- Contribution to journal › Article
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Mark
Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene
(
- Contribution to journal › Article
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Mark
Generation of an induced pluripotent stem cell line (CSC-44) from a Parkinson's disease patient carrying a compound heterozygous mutation (c.823C > T and EX6 del) in the PARK2 gene
(
- Contribution to journal › Article
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Mark
Generation of a human induced pluripotent stem cell line (CSC-40) from a Parkinson's disease patient with a PINK1 p.Q456X mutation
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- Contribution to journal › Article
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Mark
Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease
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- Contribution to journal › Article
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Mark
Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease
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- Contribution to journal › Article
- 2017
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Mark
Memory formation orchestrates the wiring of adult-born hippocampal neurons into brain circuits
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- Contribution to journal › Article
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Mark
Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease
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- Contribution to journal › Article
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Mark
Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources
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- Contribution to journal › Article
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Mark
Human astrocytes transfer aggregated alpha-synuclein via tunneling nanotubes
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- Contribution to journal › Article
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Mark
Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer's disease
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- Contribution to journal › Article
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Mark
Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease
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- Contribution to journal › Article
- 2016
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Mark
Label-free concentration of viable neurons, hESCs and cancer cells by means of acoustophoresis.
(
- Contribution to journal › Article
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Mark
α-Synuclein is a Novel Microtubule Dynamase
(
- Contribution to journal › Article
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Mark
Generating new models to study propagation and pathology of alpha-synuclein in Parkinson's disease and multiple system atrophy
2016)(
- Thesis › Doctoral thesis (compilation)
- 2015
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Mark
The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.
(
- Contribution to journal › Article
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Mark
Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors.
(
- Contribution to journal › Article
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Mark
Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease.
(
- Contribution to journal › Article
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Mark
Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models.
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- Contribution to journal › Article
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Mark
Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3'UTR.
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- Contribution to journal › Article
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Mark
Inflammatory risk factors and pathologies promoting Alzheimer's disease progression: is RAGE the key?
(
- Contribution to journal › Scientific review
- 2014
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Mark
Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
(
- Contribution to journal › Article
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Mark
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.
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- Contribution to journal › Article
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Mark
Gene Profiling of Human Induced Pluripotent Stem Cell-Derived Astrocyte Progenitors Following Spinal Cord Engraftment.
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- Contribution to journal › Article
- 2013
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Mark
Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer's Disease
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- Contribution to journal › Article
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Mark
NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease
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- Contribution to journal › Article
- 2009
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Mark
Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries.
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- Contribution to journal › Article
- 2006
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Mark
Stem Cell Plasticity Controlling Neuronal Differentiation Prior to Cell Transplantation
(
- Thesis › Doctoral thesis (compilation)
- 1998
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Mark
Human eosinophils express, relative to other circulating leukocytes, large amounts of secretory 14-kD phospholipase A2
(
- Contribution to journal › Article