Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Prognostic utility and characterization of left ventricular hypertrophy using global thickness

Lundin, Magnus ; Heiberg, Einar LU ; Nordlund, David LU ; Gyllenhammar, Tom LU ; Steding-Ehrenborg, Katarina LU ; Engblom, Henrik LU ; Carlsson, Marcus LU ; Atar, Dan ; van der Pals, Jesper LU and Erlinge, David LU orcid , et al. (2023) In Scientific Reports 13(1).
Abstract

Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wall thickness (GT, GTI if indexed to body surface area) was accurately calculated from LV mass and end-diastolic volume. Among patients with follow-up (n = 1575, median follow-up 5.4 years), the most predictive measure of death or hospitalization for heart failure was LV mass index (LVMI) (hazard ratio (HR)[95% confidence interval]... (More)

Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wall thickness (GT, GTI if indexed to body surface area) was accurately calculated from LV mass and end-diastolic volume. Among patients with follow-up (n = 1575, median follow-up 5.4 years), the most predictive measure of death or hospitalization for heart failure was LV mass index (LVMI) (hazard ratio (HR)[95% confidence interval] 1.16[1.12-1.20], p < 0.001), followed by GTI (HR 1.14[1.09-1.19], p < 0.001). Among patients with normal findings (n = 326, median follow-up 5.8 years), the most predictive measure was GT (HR 1.62[1.35-1.94], p < 0.001). GT and LVMI could characterize patients as having a normal LV mass and wall thickness, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy, and the three abnormal groups had worse prognosis than the normal group (p < 0.05 for all). LV mass is highly prognostic when mass is elevated, but GT is easily and accurately calculated, and adds value and discrimination amongst those with normal LV mass (early disease).

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiology, Left ventricular hypertrophy
in
Scientific Reports
volume
13
issue
1
article number
22806
publisher
Nature Publishing Group
external identifiers
  • scopus:85180193352
  • pmid:38129418
ISSN
2045-2322
DOI
10.1038/s41598-023-48173-7
language
English
LU publication?
yes
additional info
© 2023. The Author(s).
id
abcda6b7-9866-452b-8183-4cb961f9e11a
date added to LUP
2023-12-24 01:15:33
date last changed
2024-11-02 03:54:23
@article{abcda6b7-9866-452b-8183-4cb961f9e11a,
  abstract     = {{<p>Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wall thickness (GT, GTI if indexed to body surface area) was accurately calculated from LV mass and end-diastolic volume. Among patients with follow-up (n = 1575, median follow-up 5.4 years), the most predictive measure of death or hospitalization for heart failure was LV mass index (LVMI) (hazard ratio (HR)[95% confidence interval] 1.16[1.12-1.20], p &lt; 0.001), followed by GTI (HR 1.14[1.09-1.19], p &lt; 0.001). Among patients with normal findings (n = 326, median follow-up 5.8 years), the most predictive measure was GT (HR 1.62[1.35-1.94], p &lt; 0.001). GT and LVMI could characterize patients as having a normal LV mass and wall thickness, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy, and the three abnormal groups had worse prognosis than the normal group (p &lt; 0.05 for all). LV mass is highly prognostic when mass is elevated, but GT is easily and accurately calculated, and adds value and discrimination amongst those with normal LV mass (early disease).</p>}},
  author       = {{Lundin, Magnus and Heiberg, Einar and Nordlund, David and Gyllenhammar, Tom and Steding-Ehrenborg, Katarina and Engblom, Henrik and Carlsson, Marcus and Atar, Dan and van der Pals, Jesper and Erlinge, David and Borgquist, Rasmus and Khoshnood, Ardavan and Ekelund, Ulf and Nickander, Jannike and Themudo, Raquel and Nordin, Sabrina and Kozor, Rebecca and Bhuva, Anish N and Moon, James C and Maret, Eva and Caidahl, Kenneth and Sigfridsson, Andreas and Sörensson, Peder and Schelbert, Erik B and Arheden, Håkan and Ugander, Martin}},
  issn         = {{2045-2322}},
  keywords     = {{Cardiology; Left ventricular hypertrophy}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Prognostic utility and characterization of left ventricular hypertrophy using global thickness}},
  url          = {{https://lup.lub.lu.se/search/files/167388409/s41598-023-48173-7.pdf}},
  doi          = {{10.1038/s41598-023-48173-7}},
  volume       = {{13}},
  year         = {{2023}},
}