Lund University Publications

@article{cfa535ab-676b-4f10-a01a-a5d2c8a31200,
  abstract     = {{<p>Background: The Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Over 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Results: Adherence to the arMED score was not associated with the risk of differentiated TC (HR<sub>high vs. low adherence</sub> = 0.94, 95% CI: 0.70–1.25; p-trend 0.27), while a suggestive, but non-statistically significant inverse relationship was observed with rMED (HR<sub>high vs. low adherence</sub> = 0.88, 95% CI: 0.68–1.14; p-trend 0.17). Low meat (HR<sub>low vs. high meat intake</sub> = 0.81, 95% CI: 0.67–0.99; p-trend = 0.04) and moderate alcohol (HR<sub>moderate vs. non−moderate intake</sub> = 0.88, 95% CI: 0.75–1.03) intake were related with lower differentiated TC risk. Conclusions: Our study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.</p>}},
  author       = {{Llaha, Fjorida and Cayssials, Valerie and Farràs, Marta and Agudo, Antonio and Sandström, Maria and Eriksen, Anne Kirstine and Tjønneland, Anne and Boutron-Ruault, Marie Christine and Laouali, Nasser and Truong, Thérèse and Le Cornet, Charlotte and Katzke, Verena and Schulze, Matthias and Palli, Domenico and Krogh, Vittorio and Signoriello, Simona and Tumino, Rosario and Ricceri, Fulvio and Skeie, Guri and Jensen, Torill Miriam Enget and Chen, Sairah Lai Fa and Lasheras, Cristina and Rodriguez-Barranco, Miguel and Amiano, Pilar and Huerta, José María and Guevara, Marcela and Almquist, Martin and Nilson, Lena Maria and Hennings, Joakim and Papier, Keren and Heath, Alicia and Weiderpass, Elisabete and Rinaldi, Sabina and Zamora-Ros, Raul}},
  issn         = {{2296-861X}},
  keywords     = {{cohort; EPIC study; intake; meat; Mediterranean diet (MD); thyroid cancer (TC)}},
  language     = {{eng}},
  month        = {{09}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Nutrition}},
  title        = {{Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort : The EPIC study}},
  url          = {{http://dx.doi.org/10.3389/fnut.2022.982369}},
  doi          = {{10.3389/fnut.2022.982369}},
  volume       = {{9}},
  year         = {{2022}},
}