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A randomized trial involving a multifunctional diet reveals systematic lipid remodeling and improvements in cardiometabolic risk factors in middle aged to aged adults

Balderas Arroyo, Claudia LU ; Greño Ocariz, Maider LU ; Rogova, Oksana LU ; Al-Majdoub, Mahmoud LU ; Björck, Inger LU ; Tovar, Juscelino LU and Spégel, Peter LU (2023) In Frontiers in nutrition 10.
Abstract

BACKGROUND: A multifunctional diet (MFD) combining foods and ingredients with proven functional properties, such as fatty fish and fiber-rich foods, among others, was developed and shown to markedly reduce cardiometabolic risk-associated factors.

OBJECTIVE: Here, we aim at examining metabolic physiological changes associated with these improvements.

METHODS: Adult overweight individuals without other risk factors were enrolled in an 8-week randomized controlled intervention following a parallel design, with one group (
n  = 23) following MFD and one group (
n  = 24) adhering to a control diet (CD) that followed the caloric formula (E%) advised by the Nordic Nutritional Recommendations. Plasma metabolites and... (More)

BACKGROUND: A multifunctional diet (MFD) combining foods and ingredients with proven functional properties, such as fatty fish and fiber-rich foods, among others, was developed and shown to markedly reduce cardiometabolic risk-associated factors.

OBJECTIVE: Here, we aim at examining metabolic physiological changes associated with these improvements.

METHODS: Adult overweight individuals without other risk factors were enrolled in an 8-week randomized controlled intervention following a parallel design, with one group (
n  = 23) following MFD and one group (
n  = 24) adhering to a control diet (CD) that followed the caloric formula (E%) advised by the Nordic Nutritional Recommendations. Plasma metabolites and lipids were profiled by gas chromatography and ultrahigh performance liquid chromatography/mass spectrometry.

RESULTS: Weight loss was similar between groups. The MFD and CD resulted in altered levels of 137 and 78 metabolites, respectively. Out of these, 83 were uniquely altered by the MFD and only 24 by the CD. The MFD-elicited alterations in lipid levels depended on carbon number and degree of unsaturation.

CONCLUSION: An MFD elicits weight loss-independent systematic lipid remodeling, promoting increased circulating levels of long and highly unsaturated lipids.

CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT02148653?term=NCT02148653&draw=2&rank=1, NCT02148653.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in nutrition
volume
10
article number
1236153
pages
13 pages
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85173008848
  • pmid:37781111
ISSN
2296-861X
DOI
10.3389/fnut.2023.1236153
language
English
LU publication?
yes
id
f9019760-3ae4-4fa6-b0d2-325b9188e278
date added to LUP
2023-09-15 16:54:45
date last changed
2024-04-12 19:58:48
@article{f9019760-3ae4-4fa6-b0d2-325b9188e278,
  abstract     = {{<p>BACKGROUND: A multifunctional diet (MFD) combining foods and ingredients with proven functional properties, such as fatty fish and fiber-rich foods, among others, was developed and shown to markedly reduce cardiometabolic risk-associated factors.</p><p>OBJECTIVE: Here, we aim at examining metabolic physiological changes associated with these improvements.</p><p>METHODS: Adult overweight individuals without other risk factors were enrolled in an 8-week randomized controlled intervention following a parallel design, with one group (<br>
 n  = 23) following MFD and one group ( <br>
 n  = 24) adhering to a control diet (CD) that followed the caloric formula (E%) advised by the Nordic Nutritional Recommendations. Plasma metabolites and lipids were profiled by gas chromatography and ultrahigh performance liquid chromatography/mass spectrometry.<br>
 </p><p>RESULTS: Weight loss was similar between groups. The MFD and CD resulted in altered levels of 137 and 78 metabolites, respectively. Out of these, 83 were uniquely altered by the MFD and only 24 by the CD. The MFD-elicited alterations in lipid levels depended on carbon number and degree of unsaturation.</p><p>CONCLUSION: An MFD elicits weight loss-independent systematic lipid remodeling, promoting increased circulating levels of long and highly unsaturated lipids.</p><p>CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT02148653?term=NCT02148653&amp;draw=2&amp;rank=1, NCT02148653.</p>}},
  author       = {{Balderas Arroyo, Claudia and Greño Ocariz, Maider and Rogova, Oksana and Al-Majdoub, Mahmoud and Björck, Inger and Tovar, Juscelino and Spégel, Peter}},
  issn         = {{2296-861X}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in nutrition}},
  title        = {{A randomized trial involving a multifunctional diet reveals systematic lipid remodeling and improvements in cardiometabolic risk factors in middle aged to aged adults}},
  url          = {{http://dx.doi.org/10.3389/fnut.2023.1236153}},
  doi          = {{10.3389/fnut.2023.1236153}},
  volume       = {{10}},
  year         = {{2023}},
}