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- 2024
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Mark
Real-time monitoring of gradient chromatography using dual Kalman-filters
(
- Contribution to journal › Article
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Automatic procedure for modelling, calibration, and optimization of a three-component chromatographic separation
(
- Contribution to journal › Article
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Continuous downstream processing
(
- Contribution to journal › Article
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Mechanistic modeling of empty-full separation in recombinant adeno-associated virus production using anion-exchange membrane chromatography
(
- Contribution to journal › Article
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Mark
Accelerating vaccine manufacturing development through model-based approaches : current advances and future opportunities
(
- Contribution to journal › Scientific review
- 2023
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Mark
Methodology for fast development of digital solutions in integrated continuous downstream processing
2023) In Biotechnology and Bioengineering(
- Contribution to journal › Article
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Mark
Automated quality analysis in continuous downstream processes for small-scale applications
(
- Contribution to journal › Article
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An automated buffer management system for small-scale continuous downstream bioprocessing
(
- Contribution to journal › Article
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Real-time detection of mAb aggregates in an integrated downstream process
(
- Contribution to journal › Article
- 2022
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Binary separation control in preparative gradient chromatography using iterative learning control
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- Contribution to journal › Article
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Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand
(
- Contribution to journal › Article
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Smart platform for development of small-scale integrated continuous downstream processes
(
- Chapter in Book/Report/Conference proceeding › Book chapter
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Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies
(
- Contribution to journal › Article
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A novel process design for automated quality analysis in an integrated biopharmaceutical platform
(
- Chapter in Book/Report/Conference proceeding › Book chapter
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Mark
In-silico Formulation of Iterative Learning Control for Chromatographic Purification of Biopharmaceuticals
(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems
(
- Contribution to journal › Article
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Mark
Toward Autonomous Production of mRNA-Therapeutics in the Light of Advanced Process Control and Traditional Control Strategies for Chromatography
(
- Contribution to journal › Article
- 2021
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Mark
Optimal loading flow rate trajectory in monoclonal antibody capture chromatography
(
- Contribution to journal › Article
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Mark
An integrated continuous downstream process with real-time control: A case study with periodic countercurrent chromatography and continuous virus inactivation
2021)(
- Working paper/Preprint › Preprint in preprint archive
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Mark
An integrated continuous downstream process with real-time control : A case study with periodic countercurrent chromatography and continuous virus inactivation
(
- Contribution to journal › Article
- 2020
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Mark
Trajectory optimization of an oscillating industrial two-stage evaporator utilizing a Python-Aspen Plus Dynamics toolchain
(
- Contribution to journal › Article
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Mark
Continuous adsorption in food industry: The recovery of sinapic acid from rapeseed meal extract
(
- Contribution to journal › Article
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Mark
Model-based design and control of a small-scale integrated continuous end-to-end mAb platform
(
- Contribution to journal › Article
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Mark
Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process
(
- Contribution to journal › Article
- 2019
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Mark
Model-based monitoring of industrial reversed phase chromatography to predict insulin variants
(
- Contribution to journal › Article
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Mark
Optimization of integrated chromatography sequences for purification of biopharmaceuticals
(
- Contribution to journal › Article
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Mark
Single-shooting optimization of an industrial process through co-simulation of a modularized Aspen Plus Dynamics model
2019) 29th European Symposium on Computer Aided Process Engineering In Computer Aided Chemical Engineering 46. p.721-726(
- Chapter in Book/Report/Conference proceeding › Book chapter
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Mark
Integration of a complete downstream process for the automated lab-scale production of a recombinant protein
(
- Contribution to journal › Article
- 2018
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Mark
Multi-flowrate Optimization of the Loading Phase of a Preparative Chromatographic Separation
(
- Chapter in Book/Report/Conference proceeding › Book chapter
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Mark
Analysis of an Oscillating Two-Stage Evaporator System through Modelling and Simulation: an Industrial Case Study
(
- Contribution to journal › Article
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Mark
Design of two-column batch-to-batch recirculation to enhance performance in ion-exchange chromatography
(
- Contribution to journal › Article
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Mark
Designing an Autonomous Integrated Downstream Sequence From a Batch Separation Process − An Industrial Case Study
2018) In Biotechnology Journal(
- Contribution to journal › Article
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Mark
Multicomponent inverse modeling of supercritical fluid extraction of carotenoids, chlorophyll A, ergosterol and lipids from microalgae
(
- Contribution to journal › Article
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Mark
Mechanistic Modeling of Reversed-Phase Chromatography of Insulins within the Temperature Range 10–40 °C
(
- Contribution to journal › Article
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Mark
Pareto-optimal reversed-phase chromatography separation of three insulin variants with a solubility constraint
(
- Contribution to journal › Article
- 2017
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Mark
Design and control of integrated chromatography column sequences
(
- Contribution to journal › Article
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Mark
Mechanistic Modeling of Reversed-Phase Chromatography of Insulins with Potassium Chloride and Ethanol as Mobile-Phase Modulators
(
- Contribution to journal › Article
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Mark
Discretized multi-level elution trajectory: A proof-of-concept demonstration
(
- Contribution to journal › Article
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Mark
Unbiased Selection of Decision Variables for Optimization
2017) 27th European Symposium on Computer Aided Process Engineering In Computer Aided Chemical Engineering 40. p.253-258(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
Development and Optimization of a Single Column Analog Model for a Multi-Column Counter-Current Solvent Gradient Purification Process
(
- Chapter in Book/Report/Conference proceeding › Book chapter
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Mark
Robust Multi-Objective Optimization of Chromatographic Rare Earth Element Separation
(
- Contribution to journal › Article
- 2016
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Mark
Method development in inverse modeling applied to supercritical fluid extraction of lipids
(
- Contribution to journal › Article
- 2015
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Mark
Modeling Preparative Chromatographic Separation of Heavy Rare Earth Elements and Optimization of Thulium Purification
(
- Contribution to journal › Article
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Mark
Combined effects of potassium chloride and ethanol as mobile phase modulators on hydrophobic interaction and reversed-phase chromatography of three insulin variants
(
- Contribution to journal › Article
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Mark
Model-Based Comparison of Antibody Dimerization in Continuous and Batch-Wise Downstream Processing
(
- Contribution to journal › Article
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Mark
Dynamic Multi-Objective Optimization of Batch Chromatographic Separation Processes
2015) 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering 37. p.815-820(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
Prediction of reversible IgG1 aggregation occurring in a size exclusion chromatography column is enabled through a model based approach
(
- Contribution to journal › Article
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Mark
Multi-Objective Optimization of Chromatographic Rare Earth Element Separation
(
- Contribution to journal › Article
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Mark
Parameter Selection in the Parameter Estimation of Grade Transitions in a Polyethylene Plant
(
- Contribution to journal › Article
- 2014
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Mark
Model-Based Comparison of Batch and Continuous Preparative Chromatography in the Separation of Rare Earth Elements
(
- Contribution to journal › Article