Lars Rönnstrand
- Division of Translational Cancer Research
- Molecular Cancer Research
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Stem Cell Center
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- LUCC: Lund University Cancer Centre
- EpiHealth: Epidemiology for Health
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- 2024
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Mark
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
(
- Contribution to journal › Article
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Mark
AlphaML : A clear, legible, explainable, transparent, and elucidative binary classification platform for tabular data
(
- Contribution to journal › Article
- 2023
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Mark
A Receptor Tyrosine Kinase Inhibitor Sensitivity Prediction Model Identifies AXL Dependency in Leukemia
(
- Contribution to journal › Article
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Mark
Understanding the Role of Activation Loop Mutants in Drug Efficacy for FLT3-ITD
(
- Contribution to journal › Article
- 2022
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Mark
Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance
(
- Contribution to journal › Article
- 2020
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Mark
Why and how to investigate the role of protein phosphorylation in ZIP and ZnT zinc transporter activity and regulation
(
- Contribution to journal › Scientific review
- 2019
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Mark
The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia
(
- Contribution to journal › Letter
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Mark
The role of SRC family kinases in FLT3 signaling
(
- Contribution to journal › Scientific review
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Mark
FMS-like Tyrosine Kinase 3/FLT3 : From Basic Science to Clinical Implications
(
- Contribution to journal › Article
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Mark
Metallopeptidase inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer
(
- Contribution to journal › Article
- 2018
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Mark
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
(
- Contribution to journal › Article
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Mark
Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation
(
- Contribution to journal › Article
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Mark
SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation
(
- Contribution to journal › Article
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Mark
XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation
(
- Contribution to journal › Article
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Mark
Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma
(
- Contribution to journal › Article
- 2017
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Mark
The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation
(
- Contribution to journal › Article
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Mark
KITD816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma
(
- Contribution to journal › Article
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Mark
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling
(
- Contribution to journal › Article
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Mark
BEX3
2017) p.1-4(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
(
- Contribution to journal › Article
- 2016
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Mark
HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.
(
- Contribution to journal › Article
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Mark
FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.
(
- Contribution to journal › Article
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Mark
Expression of GADS enhances FLT3-induced mitogenic signaling.
(
- Contribution to journal › Article
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Mark
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling
(
- Contribution to journal › Article
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Mark
Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML
(
- Contribution to journal › Article
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Mark
FMS-Like Tyrosine Kinase-3
2016) p.1-4(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
Kit
2016) p.1-5(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
Src-Like Adapter Protein 2 (SLAP2)
(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
Src-Like Adapter Protein (SLAP)
2016) p.1-4(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
GRB10
2016) p.1-4(
- Chapter in Book/Report/Conference proceeding › Book chapter
- 2015
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Mark
Brain-Expressed X-linked (BEX) proteins in human cancers.
(
- Contribution to journal › Scientific review
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Mark
SOCS6 (suppressor of cytokine signaling 6)
(
- Contribution to journal › Scientific review
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Mark
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
(
- Contribution to journal › Article
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Mark
BEX1 acts as a tumor suppressor in acute myeloid leukemia.
(
- Contribution to journal › Article
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Mark
Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.
(
- Contribution to journal › Scientific review
-
Mark
The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V.
(
- Contribution to journal › Article
-
Mark
Mesenchymal – Development and Regeneration Potential.
2015) p.752-755(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Mesenchymal Stem Cells
2015) p.762-764(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
-
Mark
The PDGFR Receptor Family
2015) p.373-538(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)
2015)(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
-
Mark
Bone Marrow Transplants
2015) p.129-132(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
Drug Testing and Drug Development in Cell Culture
2015) p.363-366(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
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Mark
Fluorescence-Activated Cell Sorting
2015) p.418-420(
- Chapter in Book/Report/Conference proceeding › Entry for encyclopaedia/dictionary
-
Mark
The role of HOXB2 and HOXB3 in acute myeloid leukemia.
(
- Contribution to journal › Article
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Mark
PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner.
(
- Contribution to journal › Article
- 2014
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Mark
Keratin 19 expression correlates with poor prognosis in breast cancer
(
- Contribution to journal › Article
-
Mark
SOCS6 is a selective suppressor of receptor tyrosine kinase signaling
(
- Contribution to journal › Scientific review
-
Mark
EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation.
(
- Contribution to journal › Article
-
Mark
Src-Like Adaptor Protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling
(
- Contribution to journal › Article
-
Mark
SOCS proteins in regulation of receptor tyrosine kinase signaling.
(
- Contribution to journal › Scientific review
-
Mark
SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia.
(
- Contribution to journal › Article
-
Mark
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
(
- Contribution to journal › Article
- 2013
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Mark
The basic helix-loop-helix (bHLH) proteins in breast cancer progression
(
- Contribution to journal › Letter
-
Mark
Protein kinase C expression is deregulated in chronic lymphocytic leukemia
(
- Contribution to journal › Letter
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Mark
FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL)
(
- Contribution to journal › Letter
-
Mark
Deregulation of protein phosphatase expression in acute myeloid leukemia
(
- Contribution to journal › Article
-
Mark
Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.
(
- Contribution to journal › Article
-
Mark
Enhanced SOX10 and KIT expression in cutaneous melanoma.
(
- Contribution to journal › Letter
-
Mark
FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
(
- Contribution to journal › Article
-
Mark
Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.
(
- Contribution to journal › Article
-
Mark
Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.
(
- Contribution to journal › Article
-
Mark
The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling.
(
- Contribution to journal › Article
-
Mark
Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.
(
- Contribution to journal › Scientific review
-
Mark
The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome.
(
- Contribution to journal › Letter
- 2012
-
Mark
Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling.
(
- Contribution to journal › Article
-
Mark
HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed.
(
- Contribution to journal › Article
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Mark
Suppressor Of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated Tyr 591 and Tyr 919 of Flt3.
(
- Contribution to journal › Article
-
Mark
3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells
(
- Contribution to journal › Article
-
Mark
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3
(
- Contribution to journal › Article
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Mark
SRC is a signaling mediator in FLT3-ITD-but not in FLT3-TKD-positive AML
(
- Contribution to journal › Article
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Mark
Stem cell factor receptor/c-Kit: from basic science to clinical implications
(
- Contribution to journal › Scientific review
- 2011
-
Mark
Protein tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling
(
- Contribution to journal › Article
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Mark
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation
(
- Contribution to journal › Article
-
Mark
C-KIT Signaling Depends on Microphthalmia-Associated Transcription Factor for Effects on Cell Proliferation.
(
- Contribution to journal › Article
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Mark
Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
(
- Contribution to journal › Article
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Mark
Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase
(
- Contribution to journal › Article
-
Mark
Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice.
(
- Contribution to journal › Article
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Mark
Signaling by the Platelet-Derived Growth Factor Receptor Family
2011) p.117-124(
- Chapter in Book/Report/Conference proceeding › Book chapter
- 2010
-
Mark
Signaling by the Platelet-Derived Growth Factor Receptor Family
(
- Chapter in Book/Report/Conference proceeding › Book chapter
- 2009
-
Mark
A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML
(
- Contribution to journal › Article
-
Mark
The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.
(
- Contribution to journal › Article
-
Mark
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival.
(
- Contribution to journal › Article
-
Mark
Oncogenic flt3 receptors display different specificity and kinetics of autophosphorylation.
(
- Contribution to journal › Article
-
Mark
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3.
(
- Contribution to journal › Scientific review
-
Mark
Signaling by the Platelet-Derived Growth Factor Receptor Family
2009) p.427-434(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.
(
- Contribution to journal › Article
- 2008
-
Mark
The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.
(
- Contribution to journal › Article
-
Mark
The D816V Mutation of C-Kit Circumvents a Requirement for Sire Family Kinases in C-Kit Mediated Signal Tranduction and Transformation.
(
- Contribution to journal › Published meeting abstract
-
Mark
GAB2 is involved in differential pi3-kinase signaling by two splice forms of C-kit.
(
- Contribution to journal › Article
-
Mark
Identification Of Three Tyrosine Residues Of Importance For Survival Signaling Of Flt3 Ito Through Gab2
2008) 13th Congress of the European-Hematology-Association In Haematologica-The Hematology Journal 93. p.0461-0461(
- Contribution to journal › Published meeting abstract
-
Mark
Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.
(
- Contribution to journal › Article
-
Mark
The Identification of a Novel Stromal Stem/Progenitor Cell Phenotype in the Human Adult Prostate
2008) 23rd Annual Congress of the European Association of Urology, 2008 In European Urology Supplements 7(3). p.93-93(
- Contribution to journal › Published meeting abstract
- 2007
-
Mark
Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.
(
- Contribution to journal › Article
-
Mark
Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
(
- Contribution to journal › Article
- 2006
-
Mark
The stem cell factor receptor/c-Kit as a drug target in cancer.
(
- Contribution to journal › Scientific review
-
Mark
Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor
(
- Contribution to journal › Article
-
Mark
Receptor association and tyrosine phosphorylation of S6 kinases
(
- Contribution to journal › Article
-
Mark
Direct binding of Cbl to Tyr(568) and Tyr(936) of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation
(
- Contribution to journal › Article
-
Mark
Identification of Y589 and Y599 in the juxamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
(
- Contribution to journal › Article
-
Mark
Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
(
- Contribution to journal › Article