IPSC Laboratory for CNS Disease Modeling

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2022
Mark Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties
Azevedo, Carla ^LU ; Teku, Gabriel ^LU ; Pomeshchik, Yuriy ^LU ; Reyes, Juan F ^LU ; Chumarina, Margarita ^LU ; Russ, Kaspar ^LU ; Savchenko, Ekaterina ^LU ; Hammarberg, Anna ^LU ; Lamas, Nuno Jorge ^LU and Collin, Anna ^LU , et al. (2022) In Proceedings of the National Academy of Sciences of the United States of America 119(12).
- Contribution to journal › Article
Mark Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes
Skauli, Nadia ; Savchenko, Ekaterina ^LU ; Ottersen, Ole Petter ; Roybon, Laurent ^LU and Amiry-Moghaddam, Mahmood (2022) In Frontiers in Cellular Neuroscience 16.
- Contribution to journal › Article
2021
Mark The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
Gustavsson, Nadja ^LU ; Savchenko, Ekaterina ^LU ; Klementieva, Oxana ^LU and Roybon, Laurent ^LU (2021) In Acta Neuropathologica Communications 9(1).
- Contribution to journal › Article
Mark Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome
Peteri, Ulla Kaisa ^LU ; Pitkonen, Juho ; de Toma, Ilario ; Nieminen, Otso ; Utami, Kagistia Hana ; Strandin, Tomas M. ; Corcoran, Padraic ; Roybon, Laurent ^LU ; Vaheri, Antti and Ethell, Iryna , et al. (2021) In GLIA 69(12). p.2947-2962
- Contribution to journal › Article
Mark Generation of the human pluripotent stem-cell-derived astrocyte model with forebrain identity
Peteri, Ulla Kaisa ^LU ; Pitkonen, Juho ; Utami, Kagistia Hana ; Paavola, Jere ; Roybon, Laurent ^LU ; Pouladi, Mahmoud A. and Castrén, Maija L. (2021) In Brain Sciences 11(2).
- Contribution to journal › Article
Mark TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration
Russ, Kaspar ^LU ; Teku, Gabriel ^LU ; Bousset, Luc ; Redeker, Virginie ; Piel, Sara ^LU ; Savchenko, Ekaterina ^LU ; Pomeshchik, Yuriy ^LU ; Savistchenko, Jimmy ; Stummann, Tina C. and Azevedo, Carla ^LU , et al. (2021) In Cell Reports 34(12).
- Contribution to journal › Article
2020
Mark Stem cell-based models to study cellular alterations in Parkinson’s Disease
Chumarina, Margarita ^LU (2020) In Lund University, Faculty of Medicine Doctoral Dissertation Series
- Thesis › Doctoral thesis (compilation)
Mark NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes
Oksanen, Minna ; Hyötyläinen, Ida ; Trontti, Kalevi ; Rolova, Taisia ; Wojciechowski, Sara ; Koskuvi, Marja ; Viitanen, Matti ; Levonen, Anna Liisa ; Hovatta, Iiris and Roybon, Laurent ^LU , et al. (2020) In GLIA 68(3). p.589-599
- Contribution to journal › Article
Mark Human iPSC-Derived Hippocampal Spheroids : An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
Pomeshchik, Yuriy ^LU ; Klementieva, Oxana ^LU ; Gil, Jeovanis ^LU ; Martinsson, Isak ^LU ; Hansen, Marita Grønning ^LU ; de Vries, Tessa ^LU ; Sancho-Balsells, Anna ^LU ; Russ, Kaspar ^LU ; Savchenko, Ekaterina ^LU and Collin, Anna ^LU , et al. (2020) In Stem Cell Reports 15(1). p.256-273
- Contribution to journal › Article
Mark Unique signatures of stress-induced senescent human astrocytes
Simmnacher, Katrin ; Krach, Florian ; Schneider, Yanni ; Alecu, Julian E. ; Mautner, Lena ; Klein, Paulina ; Roybon, Laurent ^LU ; Prots, Iryna ; Xiang, Wei and Winner, Beate (2020) In Experimental Neurology 334.
- Contribution to journal › Article

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