Brain Repair and Imaging in Neural Systems (BRAINS)
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- 2024
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Mark
Image post-processing for SILMAS : structured illumination light sheet microscopy with axial sweeping
(
- Contribution to journal › Article
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Mark
Basal activity of PINK1 and PRKN in cell models and rodent brain
(
- Contribution to journal › Article
- 2023
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Mark
Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene
(
- Contribution to journal › Article
-
Mark
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease
(
- Contribution to journal › Article
-
Mark
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease
(
- Contribution to journal › Article
-
Mark
Optogenetics for controlling seizure circuits for translational approaches
(
- Contribution to journal › Article
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Mark
Immune response in blood before and after epileptic and psychogenic non-epileptic seizures
(
- Contribution to journal › Article
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Mark
Reduced epilepsy development in synapsin 2 knockout mice with autistic behavior following early systemic treatment with interleukin-6 receptor antibody
(
- Contribution to journal › Article
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Mark
Cell-specific switch for epileptiform activity : critical role of interneurons in the mouse subicular network
(
- Contribution to journal › Article
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Mark
Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation
(
- Contribution to journal › Article
- 2022
-
Mark
Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats
(
- Contribution to journal › Article
-
Mark
Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients
(
- Contribution to journal › Article
-
Mark
High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping
(
- Contribution to journal › Article
-
Mark
Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
(
- Contribution to journal › Article
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Mark
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
(
- Contribution to journal › Article
- 2021
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Mark
Viral-based rodent and nonhuman primate models of multiple system atrophy : Fidelity to the human disease
(
- Contribution to journal › Article
-
Mark
Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model
(
- Contribution to journal › Article
-
Mark
Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
(
- Contribution to journal › Article
-
Mark
Structured light sheet microscopy for high contrast 3D imaging of whole mouse brain
2021) Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 In Optics InfoBase Conference Papers(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease
(
- Contribution to journal › Article
-
Mark
Early white matter pathology in the fornix of the limbic system in Huntington disease
(
- Contribution to journal › Article
- 2020
-
Mark
Parkinson’s disease laterality : a 11C-PE2I PET imaging study
2020) In Journal of Neurology(
- Contribution to journal › Article
-
Mark
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
(
- Contribution to journal › Article
-
Mark
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
(
- Contribution to journal › Article
- 2019
-
Mark
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS) : a new animal model of relevance to schizophrenia
(
- Contribution to journal › Article
-
Mark
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease
(
- Contribution to journal › Article
-
Mark
How is alpha-synuclein cleared from the cell?
(
- Contribution to journal › Scientific review
-
Mark
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
(
- Contribution to journal › Article
- 2018
-
Mark
Multivoxel 1H-MR Spectroscopy Biometrics for Preoprerative Differentiation Between Brain Tumors
(
- Contribution to journal › Article
-
Mark
Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs
(
- Contribution to journal › Article
-
Mark
Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay
(
- Contribution to journal › Article
-
Mark
Pre- and postsynaptic dysregulation of dopamine signalling in Parkinson's disease
(
- Thesis › Doctoral thesis (compilation)
-
Mark
Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice
(
- Contribution to journal › Article
-
Mark
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein
(
- Contribution to journal › Article
- 2017
-
Mark
Gene therapy for Parkinson's disease : Disease modification by GDNF family of ligands
(
- Contribution to journal › Scientific review
-
Mark
Toxic effects of human and rodent variants of alpha-synuclein in vivo
(
- Contribution to journal › Article
-
Mark
Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats
(
- Contribution to journal › Article
-
Mark
Multibiometric multivoxel mr spectroscopy for distinction between brain tumours
(
- Contribution to journal › Published meeting abstract
-
Mark
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy : studies in rodents and nonhuman primates
(
- Contribution to journal › Article
- 2016
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Mark
Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.
(
- Contribution to journal › Article
-
Mark
Reduced baseline sensitivity to Maraviroc inhibition among R5 HIV-1 isolates from individuals with severe immunodeficiency.
(
- Contribution to journal › Letter
-
Mark
Neurochemical Signatures for the Evaluation of Disease State and Therapeutic Strategies in Neurodegenerative Diseases: a Magnetic Resonance Spectroscopy Study
2016)(
- Thesis › Doctoral thesis (compilation)
-
Mark
Pathogenic effects of alpha-synuclein: modifications and toxicity
2016)(
- Thesis › Doctoral thesis (compilation)
-
Mark
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
(
- Contribution to journal › Article
-
Mark
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?
(
- Contribution to journal › Scientific review
- 2015
-
Mark
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.
(
- Contribution to journal › Article
-
Mark
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.
(
- Contribution to journal › Article
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Mark
Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.
(
- Contribution to journal › Article
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Mark
The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.
(
- Contribution to journal › Article
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Mark
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
(
- Contribution to journal › Article
-
Mark
Selective loss of oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study.
(
- Contribution to journal › Letter
-
Mark
Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
(
- Contribution to journal › Article
-
Mark
Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
A doctor's dilemma
(
- Contribution to journal › Article
- 2014
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Mark
Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
(
- Contribution to journal › Article
-
Mark
Twisting mice move the dystonia field forward
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease
(
- Thesis › Doctoral thesis (compilation)
-
Mark
Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease
(
- Contribution to journal › Article
-
Mark
Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.
(
- Contribution to journal › Article
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Mark
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.
(
- Contribution to journal › Article
- 2013
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Mark
Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents
(
- Thesis › Doctoral thesis (compilation)
-
Mark
Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.
(
- Contribution to journal › Article
-
Mark
Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
(
- Contribution to journal › Article
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Mark
Variability in Neuronal Expression of Dopamine Receptors and Transporters in the Substantia Nigra
(
- Contribution to journal › Article
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Mark
Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies
(
- Contribution to journal › Scientific review
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Mark
Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein
(
- Contribution to journal › Article
-
Mark
LAMP2A as a therapeutic target in Parkinson disease
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents.
(
- Contribution to journal › Article
-
Mark
Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
(
- Contribution to journal › Article
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Mark
Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry
(
- Contribution to journal › Article
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Mark
Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntingtons disease
(
- Contribution to journal › Article
-
Mark
A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.
(
- Contribution to journal › Article
-
Mark
The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats
(
- Contribution to journal › Article
-
Mark
Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration
(
- Contribution to journal › Article
- 2012
-
Mark
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
(
- Contribution to journal › Article
-
Mark
Special Issue: Viral delivery of genes: new frontiers Introduction
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.
(
- Contribution to journal › Article
-
Mark
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.
(
- Contribution to journal › Article
-
Mark
GIRK2 Expression in Dopamine Neurons of the Substantia Nigra and Ventral Tegmental Area
(
- Contribution to journal › Article
-
Mark
Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
(
- Contribution to journal › Article
-
Mark
Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain
(
- Contribution to journal › Scientific review
-
Mark
Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
(
- Contribution to journal › Article
-
Mark
alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
(
- Contribution to journal › Article
-
Mark
Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
(
- Contribution to journal › Article
-
Mark
Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue.
2012) In Journal of Neurochemistry(
- Contribution to journal › Article
-
Mark
Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
(
- Contribution to journal › Article
- 2011
-
Mark
Imaging of Brain Prion Protein Amyloid in Patients with Gertstmann-Straussler-Scheinker Disease
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.
(
- Contribution to journal › Article
-
Mark
Systemic Rotenone Does Not Enhance Parkinsonian Pathology Caused By Intracerebral Alpha-Synuclein In Rats
(
- Contribution to journal › Published meeting abstract
-
Mark
GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Statistically Guided Visualization and Exploratory Analysis of Omics Data
2011)(
- Thesis › Doctoral thesis (compilation)
-
Mark
Gene therapy for Parkinson's disease shows promise.
(
- Contribution to journal › Article
-
Mark
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
(
- Contribution to journal › Article
-
Mark
Magnetic Resonance Spectroscopic Methods for the Assessment of Metabolic Functions in the Diseased Brain.
2011) In Current Topics in Behavioral Neurosciences(
- Contribution to journal › Article
-
Mark
Efficacy of L-DOPA therapy in Parkinson's disease
2011) p.454-463(
- Chapter in Book/Report/Conference proceeding › Book chapter
- 2010
-
Mark
CELL THERAPY FOR PARKINSON'S DISEASE: PERSPECTIVES ON THE CLINICAL EXPERIENCE
2010) 10th Biennial Meeting of the Asia-Pacific Society of Neurochemistry In Journal of Neurochemistry 115(Suppl. 1). p.2-2(
- Contribution to journal › Published meeting abstract
-
Mark
Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats
(
- Contribution to journal › Article
-
Mark
Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors
(
- Thesis › Doctoral thesis (compilation)
-
Mark
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease
(
- Contribution to journal › Scientific review
-
Mark
Microglia Acquire Distinct Activation Profiles Depending on the Degree of alpha-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease
(
- Contribution to journal › Article
-
Mark
Gene Therapy
(
- Contribution to journal › Published meeting abstract
-
Mark
Glial Cell Derived Neurotrophic Factor Does not Provide Neuroprotection Against Alpha-Synuclein-Induced Toxicity in a Rat Model of Parkinson's Disease
(
- Contribution to journal › Published meeting abstract
-
Mark
The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System
(
- Contribution to journal › Article
-
Mark
Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates
(
- Contribution to journal › Article
-
Mark
Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain
(
- Contribution to journal › Article
-
Mark
A simple method for large-scale generation of dopamine neurons from human embryonic stem cells.
(
- Contribution to journal › Article
-
Mark
Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.
(
- Contribution to journal › Article
-
Mark
Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses.
(
- Contribution to journal › Article
-
Mark
Gene therapy for dopamine replacement.
(
- Contribution to journal › Scientific review
-
Mark
Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats.
(
- Contribution to journal › Article
-
Mark
Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.
(
- Contribution to journal › Article
-
Mark
Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Gene therapy for Parkinson's disease.
(
- Contribution to journal › Article
- 2009
-
Mark
Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants
(
- Contribution to journal › Article
-
Mark
Are the animal models of Parkinson's disease suitable for development of neuroprotective therapies?
2009) 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders In Journal of Neurochemistry 110(Suppl 1). p.63-63(
- Contribution to journal › Published meeting abstract
-
Mark
Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.
(
- Contribution to journal › Article
-
Mark
Differential Infectivity Following Basal Ganglia Administration of Differing AAV Serotypes in Nonhuman Primates
2009) 16th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair In Cell Transplantation 18(2). p.212-213(
- Contribution to journal › Published meeting abstract
-
Mark
Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors
(
- Contribution to journal › Article
-
Mark
Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT(1A) and 5-HT(1B) receptor agonists in the rat Parkinson model.
(
- Contribution to journal › Article
-
Mark
Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
(
- Contribution to journal › Article
-
Mark
Proton NMR of (15)N-Choline Metabolites Enhanced by Dynamic Nuclear Polarization.
(
- Contribution to journal › Article
-
Mark
Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy
(
- Contribution to journal › Article
-
Mark
Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by Alpha-Synuclein Protofibrils
(
- Contribution to journal › Article
-
Mark
Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application
(
- Thesis › Doctoral thesis (compilation)
-
Mark
Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.
(
- Contribution to journal › Article
-
Mark
Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis.
(
- Contribution to journal › Article
-
Mark
Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.
(
- Contribution to journal › Article
-
Mark
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.
(
- Contribution to journal › Article
-
Mark
Huntington's Disease - New Perspectives Based on Neuroendocrine Changes in Rodent Models.
(
- Contribution to journal › Article
-
Mark
Gene therapy for dopamine replacement in Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Scientific rationale for the development of gene therapy strategies for Parkinson's disease.
(
- Contribution to journal › Article
- 2008
-
Mark
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
(
- Contribution to journal › Article
-
Mark
In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
(
- Contribution to journal › Article
-
Mark
In vivo gene delivery for development of mammalian models for Parkinson's disease
(
- Contribution to journal › Scientific review
-
Mark
Future Cell- and Gene-Based Therapies for Parkinson's Disease
2008) p.145-156(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
(
- Contribution to journal › Article
-
Mark
Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory.
2008) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 28(31). p.7797-7807(
- Contribution to journal › Article
-
Mark
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.
(
- Contribution to journal › Article
-
Mark
Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?
(
- Contribution to journal › Letter
-
Mark
Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.
(
- Contribution to journal › Article
-
Mark
Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease?
(
- Contribution to journal › Article
-
Mark
Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
(
- Contribution to journal › Article
-
Mark
Involvement of the serotonin system in L-dopa-induced dyskinesias
(
- Contribution to journal › Article
- 2007
-
Mark
Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat.
(
- Contribution to journal › Article
-
Mark
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
(
- Contribution to journal › Article
-
Mark
Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.
(
- Contribution to journal › Scientific review
-
Mark
Murine models of acute neuronopathic Gaucher disease
(
- Contribution to journal › Article
-
Mark
Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy.
(
- Contribution to journal › Article
-
Mark
The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
(
- Contribution to journal › Article
-
Mark
Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model
2007)(
- Thesis › Doctoral thesis (compilation)
-
Mark
Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133.
(
- Contribution to journal › Article
-
Mark
Targeted gene transfer in the developing central nervous system using viral vectors
2007)(
- Thesis › Doctoral thesis (compilation)
-
Mark
Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.
(
- Contribution to journal › Article
- 2006
-
Mark
Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.
(
- Contribution to journal › Article
-
Mark
Enriched environment after focal cortical ischemia enhances the generation of astroglia and NG2 positive polydendrocytes in adult rat neocortex
(
- Contribution to journal › Article
-
Mark
Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.
(
- Contribution to journal › Article
-
Mark
Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain.
(
- Contribution to journal › Article
-
Mark
Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats.
(
- Contribution to journal › Article
-
Mark
An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections
(
- Contribution to journal › Article
-
Mark
Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls
(
- Contribution to journal › Letter
-
Mark
Evidence for disease-regulated transgene expression in the brain with use of lentiviral vectors.
(
- Contribution to journal › Article
- 2005
-
Mark
Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes.
(
- Contribution to journal › Article
-
Mark
Imaging in cell-based therapy for neurodegenerative diseases.
(
- Contribution to journal › Scientific review
-
Mark
Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.
(
- Contribution to journal › Article
-
Mark
Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.
(
- Contribution to journal › Article
-
Mark
Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse.
(
- Contribution to journal › Article
-
Mark
Parkinson's disease: Viral vector delivery of parkin generates model results in rats.
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
Development of lentiviral vectors for CNS gene transfer
2005)(
- Thesis › Doctoral thesis (compilation)
-
Mark
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.
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- Contribution to journal › Article
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Mark
Cell transplantation in Parkinson's disease: how can we make it work?
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- Contribution to journal › Debate/Note/Editorial
- 2004
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Mark
Localized striatal delivery of GDNF as a treatment for Parkinson disease.
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- Contribution to journal › Article
- 2003
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Mark
Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
(
- Contribution to journal › Article
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Mark
Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.
(
- Contribution to journal › Article
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Mark
Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease.
(
- Contribution to journal › Article
- 2002
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Mark
Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer.
(
- Contribution to journal › Article
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Mark
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
(
- Contribution to journal › Article
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Mark
Neuronal replacement from endogenous precursors in the adult brain after stroke.
(
- Contribution to journal › Article
- 2001
-
Mark
Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
(
- Contribution to journal › Article
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Mark
Substitution of conserved methionines by leucines in chloroplast small heat shock protein results in loss of redox-response but retained chaperone-like activity
(
- Contribution to journal › Article
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Mark
Neuronal and fibre organization in neocortical grafts placed in post-ischaemic adult rat brain: a three-dimensional confocal microscopy study
(
- Contribution to journal › Article
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Mark
Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
2001) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 21(8). p.2889-2896(
- Contribution to journal › Article
- 2000
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Mark
Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
(
- Contribution to journal › Article
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Mark
Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
(
- Contribution to journal › Article
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Mark
Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
(
- Contribution to journal › Article
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Mark
EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum
(
- Contribution to journal › Article
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Mark
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
(
- Contribution to journal › Article
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Mark
Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement
(
- Contribution to journal › Article
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Mark
Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
(
- Contribution to journal › Article
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Mark
Environmental influence on brain-derived neurotrophic factor messenger RNA expression after middle cerebral artery occlusion in spontaneously hypertensive rats
(
- Contribution to journal › Article
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Mark
Expression of zinc-positive cells and terminals in fetal neocortical homografts to adult rat depends on lesion type and rearing conditions
(
- Contribution to journal › Article
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Mark
European neuroscience meets the snow
(
- Contribution to journal › Article
- 1999
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Mark
Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants
(
- Contribution to journal › Article
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Mark
Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
(
- Contribution to journal › Article
- 1998
-
Mark
Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
(
- Contribution to journal › Article
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Mark
Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
(
- Contribution to journal › Article
- 1997
-
Mark
Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
(
- Contribution to journal › Scientific review
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Mark
Acute contractile effects of epidermal growth factor on bladder smooth muscles. An in vivo and in vitro study in rats
(
- Contribution to journal › Article