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- 2019
- Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
-
Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells
Chapellier, Marion LU ; Peña-Martínez, Pablo LU ; Ramakrishnan, Ramprasad LU ; Eriksson, Mia LU ; Safaee-Talkhoncheh, Mehrnaz LU ; Orsmark-Pietras, Christina LU ; Lilljebjörn, Henrik LU
;
Högberg, Carl
LU
;
Hagström-Andersson, Anna
LU
and
Fioretos, Thoas
LU
, et al.
(2019)
In Haematologica
104(10).
p.2006-2016
Mark
- HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells
- Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells
- 2018
- Cohesin in haematopoiesis and leukaemia
- Pentaisomaltose, an Alternative to DMSO. Engraftment of Cryopreserved Human CD34+ Cells in Immunodeficient NSG Mice
- Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells
- 2017
- Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells
- Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration
- Forward RNAi screens in human hematopoietic stem cells
- Barcodes show family trees in ALL
- 2016
- Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
- Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs
- 2015
- Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.
- 2014
- RNA interference screening to detect targetable molecules in hematopoietic stem cells.
- 2013
- Expression of Integrin A2 Receptor in Human Cord Blood Cd34+Cd38-Cd90+ Stem Cells Engrafting Long-Term in Nod/Scid-Il2rγ(C) Null Mice.
- Outcome of Ischemic Foot Ulcer in Diabetic Patients Who Had no Invasive Vascular Intervention.
- Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem- and progenitor cells.
- Interfering with histone demethylases in HSCs.
-
FACS binding assay for analysing GDNF interactions.
Quintino, Luis LU
;
Baudet, Aurelie
LU
;
Larsson, Jonas
LU
and
Lundberg, Cecilia
LU
(2013)
In Journal of Neuroscience Methods
218(1).
p.25-28
Mark
- 2012
- Do HSCs divide asymmetrically?
- RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
- Normal Hematopoietic Stem Cell Function in Mice with Enforced Expression of the Hippo Signaling Effector YAP1.
- 2011
- Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
- Joining the stem cell maintenance squad.
- 2010
-
Chronic RPS19 Deficiency Leads to Bone Marrow Failure In a Mouse Model for Diamond Blackfan Anemia
Jaako, Pekka LU ; Flygare, Johan LU ; Olsson, Karin LU ; Quere, Ronan LU ; Larsson, Jonas LU ; Bryder, David LU and Karlsson, Stefan LU
(2010)
In Blood
116(21).
p.89-89
Mark
- Forward RNAi screens in human stem cells.
-
Cripto Selectively Expands a Distinct Population of Hematopoietic Stem Cells Expressing the Cell Surface Receptor GRP78 and Strongly Induces An Immature Phenotype In Vivo After Ex Vivo Culture
Miharada, Kenichi LU ; Karlsson, Göran LU ; Larsson, Jonas LU ; Rörby, Emma LU ; Siva, Kavitha LU and Karlsson, Stefan LU
(2010)
In Blood
116(21).
p.180-181
Mark
- CCL28 Is a Growth Factor for Human Hematopoietic Stem- and Progenitor Cells
- In Vitro RNA Interference Screen for Regulators of Adhesion in Hematopoietic Stem/Progenitor Cells
-
Cripto Selectively Expands a Distinct Population Of Hematopoietic Stem Cells Expressing Cell Surface Receptor GRP78
Miharada, Kenichi LU ; Karlsson, Göran LU ; Larsson, Jonas LU ; Rörby, Emma LU ; Siva, Kavitha LU and Karlsson, Stefan LU
(2010)
In Experimental Hematology
38(9).
p.038-038
Mark
- W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.
- 2009
-
Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation
Itoh, Fumiko ; Itoh, Susumu ; Carvalho, Rita L. C. ; Adachi, Tomomi ; Ema, Masatsugu ; Goumans, Marie-Jose ; Larsson, Jonas LU ; Karlsson, Stefan LU
;
Takahashi, Satoru
and
Mummery, Christine L.
, et al.
(2009)
In Laboratory Investigation
89(7).
p.800-810
Mark
-
A Novel Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia Locates the Erythroid Defect at CFU-E/Proerythroblast Transition
Jaako, Pekka LU ; Flygare, Johan ; Olsson, Karin LU ; Schambach, Axel ; Baum, Christopher ; Larsson, Jonas LU ; Bryder, David LU and Karlsson, Stefan LU
(2009)
In Blood
114(22).
p.79-79
Mark
- Forward RNAi screens in primary human hematopoietic stem/progenitor cells
- 2008
- W41/W41 blastocyst complementation: A versatile system to study gene function in hematopoietic stem cells
- W41/w41 blastocyst complementation: A versatile system to study gene function in hematopotetic stem cells
- Signaling via the Tgf-beta type I receptor Alk5 in heart development
- 2007
-
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma
Honjo, Yasuyuki ; Bian, Yansong ; Kawakami, Koji ; Molinolo, Alfredo ; Longenecker, Glenn ; Boppana, Ramanamurthy ; Larsson, Jonas LU ; Karlsson, Stefan LU
;
Gutkind, J. Silvio
and
Puri, Raj K.
, et al.
(2007)
In Cell Cycle
6(11).
p.1360-1366
Mark
- Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands
-
Neuron-specific TGF-beta signaling deficiency results in retinal detachment and cataracts in mice
Honjo, Yasuyuki ; Nagineni, Chandrasekharam N. ; Larsson, Jonas LU ; Nandula, Seshagiri R. ; Hooks, John J. ; Chan, Chi-Chao ; Karlsson, Stefan LU
and
Kulkarni, Ashok B.
(2007)
In Biochemical and Biophysical Research Communications
352(2).
p.418-422
Mark
-
HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.
Magnusson, Mattias LU ; Brun, Ann LU ; Miyake, Noriko LU ; Larsson, Jonas LU ; Ehinger, Mats LU ; Björnsson, Jon Mar LU ; Wutz, Anton ; Sigvardsson, Mikael LU and Karlsson, Stefan LU
(2007)
In Blood
109(9).
p.3687-3696
Mark
- 2006
-
Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion
Dudas, Marek ; Kim, Jieun ; Li, Wai-Yee ; Nagy, Andre ; Larsson, Jonas LU ; Karlsson, Stefan LU
;
Chai, Yang
and
Kaartinen, Vesa
(2006)
In Developmental Biology
296(2).
p.298-314
Mark
- Nervous activity in a stem cell niche
- Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
-
Smad7 promotes self-renewal of hematopoietic stem cells in vivo.
Blank Savukinas, Ulrika LU ; Karlsson, Göran LU ; Moody, Jennifer LU ; Utsugisawa, Taiju LU ; Magnusson, Mattias LU ; Singbrant, Sofie LU ; Larsson, Jonas LU and Karlsson, Stefan LU
(2006)
In Blood
108(13).
p.4246-4254
Mark
- 2005
-
TGF-{beta} type II receptor deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo.
Levéen, Per LU ; Carlsén, Maria LU ; Makowska, Anna LU ; Oddsson, Saemundur LU ; Larsson, Jonas LU ; Goumans, Marie-Jose ; Cilio, Corrado LU and Karlsson, Stefan LU
(2005)
In Blood
106(13).
p.4234-4240
Mark
-
Gene expression profiling demonstrates that TGF-{beta}1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-{beta} signaling.
Karlsson, Göran LU ; Liu, Yingchun LU ; Larsson, Jonas LU ; Goumans, Marie-Jose ; Lee, Ju-Seog ; Thorgeirsson, Snorri S ; Ringnér, Markus LU and Karlsson, Stefan LU
(2005)
In Physiological Genomics
21(3).
p.396-403
Mark
- The role of Smad signaling in hematopoiesis.
- Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5
-
Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo.
Larsson, Jonas LU ; Blank Savukinas, Ulrika LU ; Klintman, Jenny LU ; Magnusson, Mattias LU and Karlsson, Stefan LU
(2005)
In Experimental Hematology
33(5).
p.592-596
Mark
- 2004
-
Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice
Oe, S ; Lemmer, ER ; Conner, EA ; Factor, VM ; Levéen, Per LU ; Larsson, Jonas LU ; Karlsson, Stefan LU
and
Thorgeirsson, SS
(2004)
In Hepatology
40(5).
p.1098-1105
Mark
-
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction
Lopes, SMCDS ; Feijen, A ; Korving, J ; Korchynskyi, O ; Larsson, Jonas LU ; Karlsson, Stefan LU
;
Ten Dijke, P
;
Lyons, KM
;
Goldschmeding, R
and
Doevendans, P
, et al.
(2004)
In Developmental Dynamics
231(3).
p.542-550
Mark
-
Defective paracrine signalling by TGF beta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia
Carvalho, RLC ; Jonker, L ; Goumans, MJ ; Larsson, Jonas LU ; Bouwman, P ; Karlsson, Stefan LU
;
ten Dijke, P
;
Arthur, HM
and
Mummery, CL
(2004)
In Development
131(24).
p.6237-6247
Mark
- 2003
- Reduced proliferative capacity of hematopoietic stem cells deficient in hoxb3 and hoxb4.
-
TGF-{beta} signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro.
Larsson, Jonas LU ; Blank Savukinas, Ulrika LU ; Helgadottir, Hildur ; Björnsson, Jon Mar LU ; Ehinger, Mats LU ; Goumans, Marie-Jose ; Fan, Xiaolong LU ; Levéen, Per LU and Karlsson, Stefan LU
(2003)
In Blood
102(9).
p.3129-3135
Mark
-
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFP/ALK5 signaling
Goumans, MJ ; Valdimarsdottir, G ; Itoh, S ; Lebrin, F ; Larsson, Jonas LU ; Mummery, C ; Karlsson, Stefan LU
and
ten Dijke, P
(2003)
In Molecular Cell
12(4).
p.817-828
Mark
- 2002
-
Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable.
Levéen, Per LU ; Larsson, Jonas LU ; Ehinger, Mats LU ; Cilio, Corrado LU ; Sundler, Martin ; Jansson Sjöstrand, Lottie LU ; Holmdahl, Rikard LU and Karlsson, Stefan LU
(2002)
In Blood
100(2).
p.560-568
Mark
-
Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.
Fan, Xiaolong LU ; Valdimarsdottir, Gudrun ; Larsson, Jonas LU ; Brun, Ann LU ; Magnusson, Mattias LU ; Jacobsen, Sten Eirik W LU ; ten Dijke, Peter and Karlsson, Stefan LU
(2002)
In Journal of Immunology
168(2).
p.755-762
Mark
- The role of TGF-§ in hematopoiesis
- 2001
-
Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice
Larsson, Jonas LU ; Goumans, Marie-José ; Jansson Sjöstrand, Lottie LU ; van Rooijen, Marga A. ; Ward, Dorien ; Levéen, Per LU ; Xu, Xiufeng ; ten Dijke, Peter ; Mummery, Christine L. and Karlsson, Stefan LU
(2001)
In EMBO Journal
20(7).
p.1663-1673
Mark