Division of Molecular Medicine and Gene Therapy
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- 2014
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Mark
Gene therapy cures the anemia and lethal bone marrow failure in mouse model for RPS19-deficient Diamond-Blackfan anemia.
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- Contribution to journal › Article
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Mark
Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.
(
- Contribution to journal › Article
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Mark
Regulation of Hematopoietic Stem Cells
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- Thesis › Doctoral thesis (compilation)
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Mark
Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated Transformation.
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- Contribution to journal › Article
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Mark
The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease
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- Contribution to journal › Article
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Somatic cells with a heavy mitochondrial DNA mutational load render iPS cells with distinct differentiation defects.
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- Contribution to journal › Article
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Mark
RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib.
(
- Contribution to journal › Letter
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Hypoxic induction of vascular endothelial growth factor regulates erythropoiesis but not hematopoietic stem cell function in the fetal liver.
(
- Contribution to journal › Article
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Mark
Musculoskeletal Pain in Patients With Chronic Myeloid Leukemia After Discontinuation of Imatinib: A Tyrosine Kinase Inhibitor Withdrawal Syndrome?
(
- Contribution to journal › Letter
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Mark
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo.
(
- Contribution to journal › Article
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The epigenetic landscape of aneuploidy: constitutional mosaicism leading the way?
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- Contribution to journal › Article
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Mark
Brain pericytes acquire a microglial phenotype after stroke.
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- Contribution to journal › Article
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Mark
Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms.
(
- Contribution to journal › Article
- 2013
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Mark
Expression of Integrin A2 Receptor in Human Cord Blood Cd34+Cd38-Cd90+ Stem Cells Engrafting Long-Term in Nod/Scid-Il2rγ(C) Null Mice.
(
- Contribution to journal › Article
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Mark
Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice
(
- Contribution to journal › Article
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Mark
The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells
(
- Contribution to journal › Article
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Mark
Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
(
- Contribution to journal › Article
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Mark
Defining Regulators of Human Hematopoietic Stem Cells
(
- Thesis › Doctoral thesis (compilation)
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Mark
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.
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- Contribution to journal › Article
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Mark
40K glycoPEGylated, recombinant FVIIa: 3-month, double-blind, randomized trial of safety, pharmacokinetics, and preliminary efficacy in hemophilia patients with inhibitors.
(
- Contribution to journal › Article
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Mark
Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes
(
- Contribution to journal › Article
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Mark
Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
(
- Contribution to journal › Article
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Mark
Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients
(
- Contribution to journal › Article
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Mark
Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease
(
- Contribution to journal › Article
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Mark
Response to letter to the editor 'Serum cystatin-C levels correlate with endothelial dysfunction in patients with the metabolic syndrome'
(
- Contribution to journal › Letter
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Mark
B cell lymphoma and myeloma in murine Gaucher's disease
(
- Contribution to journal › Article
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Mark
Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells
(
- Contribution to journal › Article
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Mark
FACS binding assay for analysing GDNF interactions.
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- Contribution to journal › Article
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Mark
Interfering with histone demethylases in HSCs.
(
- Contribution to journal › Debate/Note/Editorial
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Mark
Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.
(
- Contribution to journal › Article
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Mark
Sox4 Is a Key Oncogenic Target in C/EBP alpha Mutant Acute Myeloid Leukemia
(
- Contribution to journal › Article
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Mark
Lentiviral gene transfer of TCIRG1 into peripheral blood CD34(+) cells restores osteoclast function in infantile malignant osteopetrosis.
(
- Contribution to journal › Article
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Mark
Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem- and progenitor cells.
(
- Contribution to journal › Article
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Mark
A Robust Screening Assay For Diamond Blackfan Anemia Candidate Drugs
(
- Contribution to journal › Published meeting abstract
- 2012
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Mark
Murine ameloblasts are immunonegative for Tcirg1, the v-H-ATPase subunit essential for the osteoclast plasma proton pump
(
- Contribution to journal › Article
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Mark
Genetic modeling of the Hippo pathway in hematopoietic stem cells
(
- Thesis › Doctoral thesis (compilation)
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Mark
Deciphering the Pathogenesis of Acute Myeloid Leukemia
(
- Thesis › Doctoral thesis (compilation)
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Mark
SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q- myelodysplastic syndrome.
(
- Contribution to journal › Article
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Mark
Targeting the hematopoietic stem cell to correct osteopetrosis
(
- Thesis › Doctoral thesis (compilation)
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Mark
Modeling Diamond-Blackfan Anemia in the Mouse: Disease Pathogenesis and Evaluation of Novel Therapies
(
- Thesis › Doctoral thesis (compilation)
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Mark
Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.
(
- Contribution to journal › Article
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Mark
Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions
(
- Contribution to journal › Article
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Mark
Normal Hematopoietic Stem Cell Function in Mice with Enforced Expression of the Hippo Signaling Effector YAP1.
(
- Contribution to journal › Article
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Mark
Killer-cell immunoglobulin-like receptor gene profile predicts good molecular response to dasatinib therapy in chronic myeloid leukemia
(
- Contribution to journal › Article
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Mark
RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
(
- Contribution to journal › Article
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Mark
Angptl4 maintains in vivo repopulation capacity of CD34(+) human cord blood cells.
(
- Contribution to journal › Article
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Mark
Common signaling networks characterize leukemia-initiating cells in acute myeloid leukemia.
(
- Contribution to journal › Article
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Mark
Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo.
(
- Contribution to journal › Article
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Mark
Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.
(
- Contribution to journal › Article
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Mark
Do HSCs divide asymmetrically?
(
- Contribution to journal › Article
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Mark
Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
(
- Contribution to journal › Article
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Mark
Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia.
(
- Contribution to journal › Article
- 2011
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Mark
Efficient Generation of Hematopoietic Precursors and Progenitors From Human Pluripotent Stem Cell Lines.
(
- Contribution to journal › Article
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Mark
Targeting Expression of the Leukemogenic PML-RAR alpha Fusion Protein by Lentiviral Vector-Mediated Small Interfering RNA Results in Leukemic Cell Differentiation and Apoptosis
(
- Contribution to journal › Article
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Mark
Regulation of morphogen signalling during neural patterning in the Xenopus embryo
(
- Thesis › Doctoral thesis (compilation)
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Mark
THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
(
- Thesis › Doctoral thesis (compilation)
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Mark
The role of Smad signaling in hematopoiesis and translational hematology.
(
- Contribution to journal › Article
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Mark
Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications
(
- Contribution to journal › Scientific review
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Mark
Stress hematopoiesis requires Erg
(
- Contribution to journal › Debate/Note/Editorial
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Mark
Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength
(
- Contribution to journal › Article
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Mark
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
(
- Contribution to journal › Article
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Mark
Proteasome Inhibition Improves the Muscle of Laminin {alpha}2 Chain Deficient Mice.
(
- Contribution to journal › Article
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Mark
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
(
- Contribution to journal › Scientific review
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Mark
Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche.
(
- Contribution to journal › Article
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Mark
The Vascular Repair Process after Injury of the Carotid Artery is regulated by IL-1RI and MyD88 Signalling.
(
- Contribution to journal › Article
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Mark
Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78.
(
- Contribution to journal › Article
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Mark
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
(
- Contribution to journal › Article
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Mark
(H)if blood stem cells gO 2 sleep: What can wake them up?
(
- Contribution to journal › Article
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Mark
Joining the stem cell maintenance squad.
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- Contribution to journal › Article
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Mark
Success Story of Targeted Therapy in Chronic Myeloid Leukemia: A Population-Based Study of Patients Diagnosed in Sweden From 1973 to 2008.
(
- Contribution to journal › Article
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Mark
SMAD4 binds HOXA9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by HOXA9 and leukemia transformation.
(
- Contribution to journal › Article
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Mark
Successful management of a planned pregnancy in severe congenital thrombotic thrombocytopaenic purpura: the Upshaw-Schulman syndrome.
(
- Contribution to journal › Article
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Mark
High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event.
(
- Contribution to journal › Article
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Mark
P4-09-02: G Protein-Coupled Estrogen Receptor 1 Positively Correlates with Estrogen Receptor a Expression and Increased Distant Disease-Free Survival of Breast Cancer Patients.
(
- Contribution to journal › Published meeting abstract
- 2010
-
Mark
Development of Novel Therapies in Murine Models for Gaucher Disease
2010) 7th Annual Conference of the British-Society-for-Gene-Therapy In Human Gene Therapy 21(4). p.490-491(
- Contribution to journal › Published meeting abstract
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Mark
Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
(
- Contribution to journal › Article
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Mark
Cripto Selectively Expands a Distinct Population of Hematopoietic Stem Cells Expressing the Cell Surface Receptor GRP78 and Strongly Induces An Immature Phenotype In Vivo After Ex Vivo Culture
(
- Contribution to journal › Published meeting abstract
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Mark
W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.
(
- Contribution to journal › Article
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Mark
PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression
(
- Contribution to journal › Article
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Mark
Nonablative neonatal bone marrow transplantation rapidly reverses severe murine osteopetrosis despite low level engraftment and lack of selective expansion of the osteoclastic lineage.
(
- Contribution to journal › Article
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Mark
In Vitro RNA Interference Screen for Regulators of Adhesion in Hematopoietic Stem/Progenitor Cells
2010) 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells In Experimental Hematology 38(9). p.256-256(
- Contribution to journal › Published meeting abstract
-
Mark
Chronic RPS19 Deficiency Leads to Bone Marrow Failure In a Mouse Model for Diamond Blackfan Anemia
(
- Contribution to journal › Published meeting abstract
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Mark
CCL28 Is a Growth Factor for Human Hematopoietic Stem- and Progenitor Cells
2010) 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells In Experimental Hematology 38(9). p.254-254(
- Contribution to journal › Published meeting abstract
-
Mark
A Human Model of IMO by Lentiviral Mediated shRNA Knock-down of Tcirg1 in CD34+Cells
2010) 18th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy In Human Gene Therapy 21(10). p.1458-1459(
- Contribution to journal › Published meeting abstract
-
Mark
Cripto Selectively Expands a Distinct Population Of Hematopoietic Stem Cells Expressing Cell Surface Receptor GRP78
2010) 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells In Experimental Hematology 38(9). p.038-038(
- Contribution to journal › Published meeting abstract
-
Mark
Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses
(
- Contribution to journal › Article
-
Mark
Role of Biallelic C/EBPalpha Mutations and FLT-3 LTD in Initiation and Maintenance of AML
2010) 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells In Experimental Hematology 38(9). p.250-250(
- Contribution to journal › Published meeting abstract
-
Mark
Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice
(
- Contribution to journal › Article
-
Mark
High Levels of the Adhesion Molecule CD44 on Leukemic Cells Generate Acute Myeloid Leukemia Relapse After Withdrawal of the Initial Transforming Event
(
- Contribution to journal › Published meeting abstract
-
Mark
A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy
(
- Contribution to journal › Article
-
Mark
The Success Story of Targeted Therapy In Chronic Myeloid Leukemia A Population Based Study of 3,173 Patients Diagnosed In Sweden 1973-2008
(
- Contribution to journal › Published meeting abstract
-
Mark
SMAD4 Sequestrates HOXA9 to Protect Hematopoietic Stem Cells Against Leukemia Transformation
(
- Contribution to journal › Published meeting abstract
-
Mark
The Proportion of Ph+CD34(+)CD38(neg) Leukemic Stem Cells In the Bone Marrow of Newly Diagnosed Patients with Chronic Myeloid Leukemia (CML) In Chronic Phase (CP) Is Variable and Correlates with High Sokal Risk, High Leukocyte Count, Low Hemoglobin Concentration, Splenomegaly and Increased Hematological Toxicity During Initial TKI Therapy Data From a Randomized Phase II NordCML006 Study
(
- Contribution to journal › Published meeting abstract
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Mark
Second-Generation BCR-ABL Kinase Inhibitors in CML
(
- Contribution to journal › Letter
-
Mark
Successful Treatment of Metachromatic Leukodystrophy Using Bone Marrow Transplantation of HoxB4 Overexpressing Cells
(
- Contribution to journal › Article
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Mark
Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.
(
- Contribution to journal › Article
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Mark
Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.
(
- Contribution to journal › Article
-
Mark
Forward RNAi screens in human stem cells.
(
- Contribution to journal › Article
-
Mark
Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.
(
- Contribution to journal › Article
- 2009
-
Mark
Dissociation of bone resorption and bone formation in adult mice transplanted with OC/OC hematopoietic stem cells
(
- Contribution to journal › Published meeting abstract