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- 2024
-
Mark
The history and status of dopamine cell therapies for Parkinson's disease
2024) In BioEssays(
- Contribution to journal › Scientific review
-
Mark
The AAV-α-Synuclein Model of Parkinson's Disease : An Update
2024) In Journal of Parkinson's Disease(
- Contribution to journal › Scientific review
- 2023
-
Mark
Restorative cell and gene therapies for Parkinson's disease
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Athymic Nude Rat Brain Atlas
2023)(
- Book/Report › Book
- 2022
-
Mark
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System
(
- Contribution to journal › Scientific review
- 2021
-
Mark
Dopamine Cell Therapy : From Cell Replacement to Circuitry Repair
(
- Contribution to journal › Scientific review
-
Mark
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease
(
- Contribution to journal › Article
-
Mark
Repairing the Parkinson Brain
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
In vivo conversion of dopamine neurons in mouse models of Parkinson's disease - a future approach for regenerative therapy?
(
- Contribution to journal › Scientific review
-
Mark
Stem Derived Dopamine Neurons : Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?
(
- Contribution to journal › Article
-
Mark
GDNF Therapy : Can We Make It Work?
(
- Contribution to journal › Article
- 2020
-
Mark
Parkinson’s disease laterality : a 11C-PE2I PET imaging study
2020) In Journal of Neurology(
- Contribution to journal › Article
-
Mark
BDNF Overexpression Increases Striatal D3 Receptor Level at Striatal Neurons and Exacerbates D1-Receptor Agonist-Induced Dyskinesia
(
- Contribution to journal › Article
-
Mark
Animal Models of Parkinson's Disease : Are They Useful or Not?
(
- Contribution to journal › Scientific review
-
Mark
Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair : 40 Years in Perspective
(
- Contribution to journal › Scientific review
-
Mark
Transsynaptic tracing and its emerging use to assess graftreconstructed neural circuits
(
- Contribution to journal › Article
-
Mark
From Skin to Brain : A Parkinson's Disease Patient Transplanted with His Own Cells
(
- Contribution to journal › Article
-
Mark
Animal models for preclinical Parkinson´s research: An update and critical appraisal
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD
2020) In Proceedings of the National Academy of Sciences of the United States of America 117(26). p.15209-15220(
- Contribution to journal › Article
- 2019
-
Mark
The amphetamine induced rotation test : A re-assessment of its use as a tool to monitor motor impairment and functional recovery in rodent models of Parkinson's disease
(
- Contribution to journal › Scientific review
-
Mark
Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease
(
- Contribution to journal › Article
-
Mark
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease
(
- Contribution to journal › Article
-
Mark
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease
(
- Contribution to journal › Article
- 2018
-
Mark
Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats
(
- Contribution to journal › Article
-
Mark
The serotonergic system in L-DOPA-induced dyskinesia : pre-clinical evidence and clinical perspective
(
- Contribution to journal › Article
-
Mark
Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson’s disease
(
- Contribution to journal › Article
- 2017
-
Mark
Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
2017) In Proceedings of the National Academy of Sciences of the United States of America 114(39). p.8284-8293(
- Contribution to journal › Article
-
Mark
Mechanisms and use of neural transplants for brain repair
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Preface
(
- Chapter in Book/Report/Conference proceeding › Foreword/Postscript
-
Mark
BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats
(
- Contribution to journal › Article
-
Mark
Replacing Dopamine Neurons in Parkinson's Disease : How did it happen?
(
- Contribution to journal › Scientific review
-
Mark
Preface
(
- Chapter in Book/Report/Conference proceeding › Foreword/Postscript
- 2016
-
Mark
α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter
(
- Contribution to journal › Article
- 2015
-
Mark
Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.
(
- Contribution to journal › Article
-
Mark
Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells.
(
- Contribution to journal › Scientific review
-
Mark
GDNF is not required for catecholaminergic neuron survival in vivo.
(
- Contribution to journal › Letter
-
Mark
Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression.
(
- Contribution to journal › Article
-
Mark
Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors.
(
- Contribution to journal › Article
-
Mark
The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study.
(
- Contribution to journal › Article
-
Mark
Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.
2015) In Biological Psychiatry(
- Contribution to journal › Article
- 2014
-
Mark
The anti-dyskinetic effect of dopamine receptor blockade is enhanced in parkinsonian rats following dopamine neuron transplantation.
(
- Contribution to journal › Article
- 2013
-
Mark
Anti-dyskinetic effect of anpirtoline in animal models of L-DOPA-induced dyskinesia
(
- Contribution to journal › Article
-
Mark
Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
(
- Contribution to journal › Article
-
Mark
Generation of induced neurons via direct conversion in vivo.
(
- Contribution to journal › Article
-
Mark
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.
(
- Contribution to journal › Article
- 2012
-
Mark
Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons.
(
- Contribution to journal › Article
-
Mark
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.
(
- Contribution to journal › Article
-
Mark
Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson's Patients Treated with Dopamine Grafts
(
- Contribution to journal › Article
-
Mark
α-Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons.
(
- Contribution to journal › Article
-
Mark
Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo.
(
- Contribution to journal › Article
-
Mark
Amphetamine-induced rotation and l-DOPA-induced dyskinesia in the rat 6-OHDA model: A correlation study.
(
- Contribution to journal › Article
-
Mark
Introduction (Part I)
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Introduction (Part II)
(
- Chapter in Book/Report/Conference proceeding › Book chapter
-
Mark
Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation
(
- Chapter in Book/Report/Conference proceeding › Book chapter
- 2011
-
Mark
Direct conversion of human fibroblasts to dopaminergic neurons.
(
- Contribution to journal › Article
-
Mark
Cell Therapeutics in Parkinson's Disease.
(
- Contribution to journal › Article
-
Mark
Gene therapy for Parkinson's disease shows promise.
(
- Contribution to journal › Article
- 2010
-
Mark
Recent Advances In Parkinson'S Disease: Translational And Clinical Research Preface
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia
(
- Contribution to journal › Scientific review
-
Mark
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease
(
- Contribution to journal › Scientific review
-
Mark
Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants
(
- Contribution to journal › Article
-
Mark
New Mouse Models for Studying Postnatal Role of GDNF In Vivo
2010) 17th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair In Cell Transplantation 19(3). p.331-331(
- Contribution to journal › Published meeting abstract
-
Mark
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.
(
- Contribution to journal › Article
- 2009
-
Mark
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
(
- Contribution to journal › Article
-
Mark
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
(
- Contribution to journal › Article
-
Mark
Differential Infectivity Following Basal Ganglia Administration of Differing AAV Serotypes in Nonhuman Primates
2009) 16th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair In Cell Transplantation 18(2). p.212-213(
- Contribution to journal › Published meeting abstract
-
Mark
Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts
(
- Contribution to journal › Scientific review
-
Mark
Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.
(
- Contribution to journal › Article
-
Mark
Gene therapy for dopamine replacement in Parkinson's disease.
(
- Contribution to journal › Article
- 2008
-
Mark
Embryonic dopaminergic precursors can be isolated at different states of differentiation and function upon grafting into an animal model of Parkinson's disease
2008) 17th Biennial Meeting of the International-Society-for-Developmental-Neuroscience In International Journal of Developmental Neuroscience 26(8). p.887-888(
- Contribution to journal › Published meeting abstract
-
Mark
In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
(
- Contribution to journal › Article
-
Mark
Gene therapy for Parkinson's disease
2008) 19th Helsinki Drug Research 2008 In European Journal of Pharmaceutical Sciences 34(1, Suppl. 1). p.14-14(
- Contribution to journal › Published meeting abstract
-
Mark
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
(
- Contribution to journal › Article
-
Mark
Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
(
- Contribution to journal › Article
-
Mark
Involvement of the serotonin system in L-dopa-induced dyskinesias
(
- Contribution to journal › Article
- 2007
-
Mark
Dopamine neuron systems in the brain: an update
(
- Contribution to journal › Scientific review
-
Mark
In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133.
(
- Contribution to journal › Article
-
Mark
Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
(
- Contribution to journal › Article
- 2006
-
Mark
Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.
(
- Contribution to journal › Article
- 2005
-
Mark
Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.
(
- Contribution to journal › Article
-
Mark
Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse.
(
- Contribution to journal › Article
-
Mark
Parkinson's disease: Viral vector delivery of parkin generates model results in rats.
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor.
(
- Contribution to journal › Article
-
Mark
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.
(
- Contribution to journal › Article
-
Mark
Cell transplantation in Parkinson's disease: how can we make it work?
(
- Contribution to journal › Debate/Note/Editorial
- 2004
-
Mark
Cell Therapy in Parkinson's Disease.
(
- Contribution to journal › Article
-
Mark
Localized striatal delivery of GDNF as a treatment for Parkinson disease.
(
- Contribution to journal › Article
-
Mark
Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression.
2004) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 24(31). p.6958-6967(
- Contribution to journal › Article
-
Mark
Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.
(
- Contribution to journal › Article
-
Mark
Special Issue Stem Cells - Preface
(
- Contribution to journal › Debate/Note/Editorial
- 2003
-
Mark
Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro.
(
- Contribution to journal › Article
-
Mark
Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model.
(
- Contribution to journal › Article
-
Mark
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.
(
- Contribution to journal › Scientific review
-
Mark
Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease.
(
- Contribution to journal › Article
- 2002
-
Mark
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
(
- Contribution to journal › Article
-
Mark
Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector.
(
- Contribution to journal › Article