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- 2024
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Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis
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- Contribution to journal › Article
- 2023
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Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint
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- Contribution to journal › Article
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Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin-antitoxin operon
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- Contribution to journal › Article
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Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria : VmlR2, Ard1 and CplR
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- Contribution to journal › Article
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Mark
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems
2023) In Proceedings of the National Academy of Sciences of the United States of America 120(33). p.1-12(
- Contribution to journal › Article
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Mark
The structure of DarB in complex with RelNTD reveals nonribosomal activation of Rel stringent factors
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- Contribution to journal › Article
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Prediction of COVID-19 positive cases, a nation-wide SARS-CoV-2 wastewater-based epidemiology study
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- Contribution to journal › Article
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Escherichia coli CspA stimulates translation in the cold of its own mRNA by promoting ribosome progression
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- Contribution to journal › Article
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Uncovering new families and folds in the natural protein universe
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- Contribution to journal › Article
- 2022
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Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation
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- Contribution to journal › Letter
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Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
(
- Contribution to journal › Article
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A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains
2022) In Proceedings of the National Academy of Sciences of the United States of America 119(6). p.1-12(
- Contribution to journal › Article
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Mark
Sal-type ABC-F proteins : Intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci
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- Contribution to journal › Article
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Direct activation of a bacterial innate immune system by a viral capsid protein
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- Contribution to journal › Article
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Synthetic oxepanoprolinamide iboxamycin is active against Listeria monocytogenes despite the intrinsic resistance mediated by VgaL/Lmo0919 ABCF ATPase
(
- Contribution to journal › Article
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Mark
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp
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- Contribution to journal › Article
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Mark
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes
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- Contribution to journal › Article
- 2021
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(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains
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- Contribution to journal › Article
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Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis
(
- Contribution to journal › Article
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Mark
Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
(
- Contribution to journal › Article
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Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
(
- Contribution to journal › Article
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Mark
Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools
(
- Contribution to journal › Article
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
(
- Contribution to journal › Article
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RqcH and RqcP catalyze processive poly-alanine synthesis in a reconstituted ribosome-associated quality control system
(
- Contribution to journal › Article
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Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA
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- Contribution to journal › Article
- 2020
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Hfq-Assisted RsmA Regulation Is Central to Pseudomonas aeruginosa Biofilm Polysaccharide PEL Expression
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- Contribution to journal › Article
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In Vitro Studies of Persister Cells
(
- Contribution to journal › Article
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Target protection as a key antibiotic resistance mechanism
(
- Contribution to journal › Scientific review
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A widespread toxin−antitoxin system exploiting growth control via alarmone signaling
2020) In Proceedings of the National Academy of Sciences of the United States of America 117(19). p.10500-10510(
- Contribution to journal › Article
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Mark
A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes
(
- Contribution to journal › Article
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Mark
The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes
(
- Contribution to journal › Article
- 2019
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Mark
A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling
(
- Contribution to journal › Article
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Mark
Analysis of nucleotide pools in bacteria using HPLC-MS in HILIC mode
(
- Contribution to journal › Article
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Mark
Intramolecular interactions dominate the autoregulation of escherichia coli stringent factor RelA
(
- Contribution to journal › Article
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Mark
The Rel stringent factor from Thermus thermophilus : Crystallization and X-ray analysis
(
- Contribution to journal › Article
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Mark
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance : Structural and Functional Diversification across the Tree of Life
(
- Contribution to journal › Article
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Mark
Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
(
- Contribution to journal › Article
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Mark
Reanalysis of proteomics results fails to detect mazf-mediated stress proteins
(
- Contribution to journal › Letter
- 2018
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Mark
Elimination of Ribosome Inactivating Factors Improves the Efficiency of Bacillus subtilis and Saccharomyces cerevisiae Cell-Free Translation Systems
(
- Contribution to journal › Article
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Mark
Reassessing the role of type II toxin-antitoxin systems in formation of escherichia coli type II persister cells
(
- Contribution to journal › Article
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Mark
The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
(
- Contribution to journal › Article
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Mark
Reply to Holden and Errington, “Type II toxin-antitoxin systems and persister cells”
(
- Contribution to journal › Letter
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Mark
Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR
2018) In Proceedings of the National Academy of Sciences of the United States of America 115(36). p.8978-8983(
- Contribution to journal › Article
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Mark
Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest
(
- Contribution to journal › Article
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Mark
Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP
(
- Contribution to journal › Article
- 2017
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Mark
Subinhibitory concentrations of bacteriostatic antibiotics induce relA-dependent and relA-independent tolerance to β-lactams
(
- Contribution to journal › Article
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Mark
Small Alarmone Synthetases as novel bacterial RNA-binding proteins
(
- Contribution to journal › Scientific review
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Mark
Molecular mutagenesis of ppGpp : Turning a RelA activator into an inhibitor
(
- Contribution to journal › Article
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Mark
Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA
2017) In Proceedings of the National Academy of Sciences of the United States of America 114(14). p.3726-3731(
- Contribution to journal › Article
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Mark
HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp
(
- Contribution to journal › Article
- 2016
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Mark
Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products
(
- Contribution to journal › Article
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Mark
Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp
(
- Contribution to journal › Article
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Mark
Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes
(
- Contribution to journal › Article
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Mark
The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis
(
- Contribution to journal › Article
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Mark
Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors
(
- Contribution to journal › Article
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Mark
Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli
(
- Contribution to journal › Article
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Mark
Aim-less translation : Loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis
(
- Contribution to journal › Article
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Mark
Persisters—as elusive as ever
(
- Contribution to journal › Scientific review
- 2015
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Mark
Recent functional insights into the role of (p)ppGpp in bacterial physiology
(
- Contribution to journal › Scientific review
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Mark
Fusidic acid targets elongation factor G in several stages of translocation on the bacterial ribosome
(
- Contribution to journal › Article
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Mark
From (p)ppGpp to (pp)pGpp : Characterization of regulatory effects of pGpp synthesized by the small alarmone synthetase of Enterococcus faecalis
(
- Contribution to journal › Article
- 2014
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Mark
Mitochondrial translation initiation machinery : Conservation and diversification
(
- Contribution to journal › Scientific review
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Mark
An evolutionary ratchet leading to loss of elongation factors in eukaryotes
(
- Contribution to journal › Article
- 2013
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Mark
Protein biosynthesis in mitochondria
(
- Contribution to journal › Scientific review
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Mark
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
(
- Contribution to journal › Article
- 2012
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Mark
Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae
(
- Contribution to journal › Article
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Mark
GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner
(
- Contribution to journal › Article
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Mark
Positive allosteric feedback regulation of the stringent response enzyme RelA by its product
(
- Contribution to journal › Article
- 2011
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Mark
Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40
(
- Contribution to journal › Article
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Mark
Single-molecule investigations of the stringent response machinery in living bacterial cells
2011) In Proceedings of the National Academy of Sciences of the United States of America 108(31). p.365-373(
- Contribution to journal › Article
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Mark
The RelA/SpoT Homolog (RSH) superfamily : Distribution and functional evolution of ppgpp synthetases and hydrolases across the tree of life
(
- Contribution to journal › Article
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Mark
An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea
(
- Contribution to journal › Article
- 2010
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Mark
Structure of the Dom34-Hbs1 complex and implications for no-go decay
(
- Contribution to journal › Article
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Mark
Thermodynamic Characterization of ppGpp Binding to EF-G or IF2 and of Initiator tRNA Binding to Free IF2 in the Presence of GDP, GTP, or ppGpp
(
- Contribution to journal › Article
- 2009
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Mark
GTP-dependent structural rearrangement of the eRF1:eRF3 complex and eRF3 sequence motifs essential for PABP binding
(
- Contribution to journal › Article
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Mark
Thermodynamics of GTP and GDP Binding to Bacterial Initiation Factor 2 Suggests Two Types of Structural Transitions
(
- Contribution to journal › Article
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Mark
Does the ribosome have initiation and elongation modes of translation?
(
- Contribution to journal › Letter
- 2008
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Mark
Evolution of nonstop, no-go and nonsense-mediated mRNA decay and their termination factor-derived components
(
- Contribution to journal › Article
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Mark
The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form
2008) In Proceedings of the National Academy of Sciences of the United States of America 105(41). p.15678-15683(
- Contribution to journal › Article
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Mark
The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome
(
- Contribution to journal › Article
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Mark
Cofactor dependent conformational switching of GTPases
(
- Contribution to journal › Article
- 2007
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Mark
Evolution of translational machinery : Could translation termination come into being before elongation?
(
- Contribution to journal › Letter
- 2006
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Mark
Two-Step Selection of mRNAs in Initiation of Protein Synthesis
(
- Contribution to journal › Letter
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Mark
GTPases of the prokaryotic translation apparatus
(
- Contribution to journal › Scientific review
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Mark
Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3
(
- Contribution to journal › Article
- 2005
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Mark
Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs
(
- Contribution to journal › Article
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Mark
Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G
(
- Contribution to journal › Article