Leif Groop
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- 2013
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Mark
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.
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- Contribution to journal › Article
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Mark
Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.
(
- Contribution to journal › Article
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Mark
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
(
- Contribution to journal › Article
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Mark
Alterations in bile acid synthesis in carriers of HNF1α mutations.
(
- Contribution to journal › Article
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Mark
Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
(
- Contribution to journal › Article
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Mark
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
(
- Contribution to journal › Article
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Mark
Genetics of diabetes - Are we missing the genes or the disease?
2013) In Molecular and Cellular Endocrinology(
- Contribution to journal › Article
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Mark
THOC5 : A novel gene involved in HDL-cholesterol metabolism
(
- Contribution to journal › Article
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Maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
2013)(
- Contribution to conference › Poster
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Mark
The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
(
- Contribution to journal › Article
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Mark
A link between GIP and osteopontin in adipose tissue and insulin resistance.
(
- Contribution to journal › Article
- 2012
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Mark
Subjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes The PPP-Botnia Study
(
- Contribution to journal › Article
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Mark
Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.
(
- Contribution to journal › Article
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Mark
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
(
- Contribution to journal › Article
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Mark
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
(
- Contribution to journal › Article
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Mark
Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes - A role for the transcription factor NFAT and phosphodiesterase 3B.
(
- Contribution to journal › Article
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Mark
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
(
- Contribution to journal › Article
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Mark
A Single Nucleotide Polymorphism Associates With the Response of Muscle ATP Synthesis to Long-Term Exercise Training in Relatives of Type 2 Diabetic Humans
(
- Contribution to journal › Article
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Mark
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
(
- Contribution to journal › Article
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Mark
Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
(
- Contribution to journal › Article
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Mark
SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
(
- Contribution to journal › Article
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Mark
First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
(
- Contribution to journal › Article
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Mark
Analysis of case-control association studies with known risk variants
(
- Contribution to journal › Article
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Mark
Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study
(
- Contribution to journal › Article
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Mark
Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
(
- Contribution to journal › Article
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Mark
Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study
(
- Contribution to journal › Article
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Mark
FTO genotype is associated with phenotypic variability of body mass index
(
- Contribution to journal › Article
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Mark
New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
(
- Contribution to journal › Article
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Mark
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
(
- Contribution to journal › Article
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Mark
Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
(
- Contribution to journal › Article
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Mark
Reduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
(
- Contribution to journal › Article
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Mark
Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus
(
- Contribution to journal › Article
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Mark
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
(
- Contribution to journal › Article
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Mark
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
(
- Contribution to journal › Article
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Mark
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
(
- Contribution to journal › Article
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Mark
Association between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: Results from the PPP-Botnia Study
(
- Contribution to journal › Article
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Mark
Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).
2012) In Diabetes(
- Contribution to journal › Article
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Mark
Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
(
- Contribution to journal › Article
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Mark
Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
2012) In Diabetologia(
- Contribution to journal › Article
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Mark
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
(
- Contribution to journal › Article
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Mark
The Triglyceride Content in Skeletal Muscle Is Associated with Hepatic But Not Peripheral Insulin Resistance in Elderly Twins.
2012) In The Journal of clinical endocrinology and metabolism(
- Contribution to journal › Article
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Mark
Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.
2012) In Diabetologia(
- Contribution to journal › Article
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Mark
A common variant upstream of the PAX6 gene influences islet function in man.
(
- Contribution to journal › Article
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Mark
Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.
2012) In Diabetologia(
- Contribution to journal › Article
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Mark
Intraorbital deiodinase type 2 expression is downregulated in chronic phase of Graves' ophthalmopathy.
(
- Contribution to journal › Letter
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Mark
Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.
(
- Contribution to journal › Article
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Mark
Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance.
(
- Contribution to journal › Article
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Mark
Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
(
- Contribution to journal › Article
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Mark
Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
2012) In Diabetes(
- Contribution to journal › Article
- 2011
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Mark
Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
(
- Contribution to journal › Article
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Mark
The Genetic Structure of the Swedish Population
(
- Contribution to journal › Article
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Mark
Two-Step Approach for the Prediction of Future Type 2 Diabetes Risk
(
- Contribution to journal › Article
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Mark
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction
(
- Contribution to journal › Article
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Mark
FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
(
- Contribution to journal › Article
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Mark
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
(
- Contribution to journal › Article
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Mark
Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance The PPP-Botnia Study
(
- Contribution to journal › Article
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Mark
Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current
(
- Contribution to journal › Article
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Mark
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
(
- Contribution to journal › Article
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Mark
High prevalence of type 2 diabetes in Iraqi and Swedish residents in a deprived Swedish neighbourhood - a population based study
(
- Contribution to journal › Article
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Mark
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
(
- Contribution to journal › Article
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Mark
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
(
- Contribution to journal › Article
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Mark
Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
(
- Contribution to journal › Article
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Mark
Power in the Phenotypic Extremes: A Simulation Study of Power in Discovery and Replication of Rare Variants
(
- Contribution to journal › Article
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Mark
Two common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.
(
- Contribution to journal › Article
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Mark
LifeGene-a large prospective population-based study of global relevance
(
- Contribution to journal › Article
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Mark
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
(
- Contribution to journal › Article
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Mark
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
(
- Contribution to journal › Article
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Mark
A common variant near the PRL gene is associated with increased adiposity in males
(
- Contribution to journal › Article
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Mark
Relation between cycling exercise capacity, fiber-type composition, and lower extremity muscle strength and muscle endurance.
(
- Contribution to journal › Article
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Mark
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
(
- Contribution to journal › Article
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Mark
Genetics of Type 2 Diabetes.
(
- Contribution to journal › Scientific review
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Mark
The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
(
- Contribution to journal › Article
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Mark
Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.
(
- Contribution to journal › Article
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Mark
Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.
(
- Contribution to journal › Article
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Mark
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.
(
- Contribution to journal › Article
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Mark
Uromodulin gene variant is associated with type 2 diabetic nephropathy.
(
- Contribution to journal › Article
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Mark
Upper Body Muscle Strength and Endurance in Relation to Peak Exercise Capacity During Cycling in Healthy Sedentary Male Subjects.
(
- Contribution to journal › Article
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Mark
Gene Expression in Graves' Ophthalmopathy and Arm Lymphedema: Similarities and Differences.
(
- Contribution to journal › Article
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Mark
Facilitation of information exhange between genetic research, primary health care and decision makers using a regional diabetes register DIREVA (Diabetes Register Vaasa)
2011) 5th International Multi-Conference on Society, Cybernetics and Informatics, IMSCI 2011 1. p.288-288(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
Survival of rat pancreatic islets is partly controlled by a TCF7L2-p53-p53INP1 dependent pathway
(
- Contribution to journal › Article
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Mark
Genetics of type 2 diabetes
(
- Contribution to journal › Scientific review
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Mark
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
(
- Contribution to journal › Article
- 2010
-
Mark
GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
(
- Contribution to journal › Article
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Mark
Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
(
- Contribution to journal › Article
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Mark
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
(
- Contribution to journal › Article
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Mark
Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years
(
- Contribution to journal › Article
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Mark
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
(
- Contribution to journal › Article
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Mark
Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
(
- Contribution to journal › Article
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Mark
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
(
- Contribution to journal › Article
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Mark
Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
(
- Contribution to journal › Article
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Mark
Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
(
- Chapter in Book/Report/Conference proceeding › Paper in conference proceeding
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Mark
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
(
- Contribution to journal › Article
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Mark
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
(
- Contribution to journal › Article
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Mark
Stressful Life Events and the Metabolic Syndrome - The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia Study
(
- Contribution to journal › Article
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Mark
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
(
- Contribution to journal › Article
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Mark
TCF7L2-conferred apoptosis in pancreatic beta cells involves the p53 pathway
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.298-298(
- Contribution to journal › Published meeting abstract
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Mark
A mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.705-705(
- Contribution to journal › Published meeting abstract
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Mark
Analysis of TBC1D4 in patients with severe insulin resistance
(
- Contribution to journal › Letter
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Mark
An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
(
- Contribution to journal › Article
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Mark
Differences in associations between HSD11B1 gene expression and metabolic parameters in subjects with and without impaired glucose homeostasis
(
- Contribution to journal › Article