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- 2024
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Mark
The dual incretin co-agonist tirzepatide increases both insulin secretion and glucose effectiveness in model experiments in mice
(
- Contribution to journal › Article
- 2023
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Mark
Contribution of GIP and GLP-1 to the Insulin Response to Oral Administration of Glucose in Female Mice
(
- Contribution to journal › Article
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Mark
Gut hormone-based pharmacology : novel formulations and future possibilities for metabolic disease therapy
(
- Contribution to journal › Scientific review
-
Mark
Paradigm Shift in the Management of Metabolic Diseases—Next-Generation Incretin Therapy
(
- Contribution to journal › Scientific review
- 2022
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Mark
Temporal Patterns of Glucagon and Its Relationships with Glucose and Insulin following Ingestion of Different Classes of Macronutrients
(
- Contribution to journal › Article
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Mark
Assessing the Effect of Incretin Hormones and Other Insulin Secretagogues on Pancreatic Beta-Cell Function : Review on Mathematical Modelling Approaches
(
- Contribution to journal › Scientific review
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Mark
The Glucose Sensitivity of Insulin Secretion-Lessons from In Vivo and In Vitro Studies in Mice
(
- Contribution to journal › Article
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Mark
Glucose-dependent insulinotropic polypeptide secretion after oral macronutrient ingestion : The human literature revisited and a systematic study in model experiments in mice
(
- Contribution to journal › Article
- 2021
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Mark
Glucose effectiveness : Lessons from studies on insulin-independent glucose clearance in mice
(
- Contribution to journal › Scientific review
-
Mark
The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice : Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice
(
- Contribution to journal › Article
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Mark
Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice
(
- Contribution to journal › Article
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Mark
Mathematical Model of Glucagon Kinetics for the Assessment of Insulin-Mediated Glucagon Inhibition During an Oral Glucose Tolerance Test
(
- Contribution to journal › Article
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Mark
Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice
(
- Contribution to journal › Article
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Mark
Glucose-lowering action through targeting islet dysfunction in type 2 diabetes : Focus on dipeptidyl peptidase-4 inhibition
(
- Contribution to journal › Scientific review
-
Mark
Hepatic and extrahepatic insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors
(
- Contribution to journal › Article
-
Mark
The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice
(
- Contribution to journal › Article
- 2020
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Mark
Persistent whole day meal effects of three dipeptidyl peptidase-4 inhibitors on glycaemia and hormonal responses in metformin-treated type 2 diabetes
(
- Contribution to journal › Article
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Mark
The incretin effect in female mice with double deletion of GLP-1 and GIP receptors
(
- Contribution to journal › Article
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Mark
Consequences on islet and incretin hormone responses to dinner by omission of lunch in healthy men
(
- Contribution to journal › Article
- 2019
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Mark
Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice
2019) In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 316(1). p.27-37(
- Contribution to journal › Article
-
Mark
Glucagon-like peptide-1 receptor agonists for type 2 diabetes : A rational drug development
(
- Contribution to journal › Article
-
Mark
Effect of Liraglutide on Times in Glycaemic Ranges as Assessed by CGM for Type 2 Diabetes Patients Treated With Multiple Daily Insulin Injections
(
- Contribution to journal › Article
-
Mark
Islet adaptation in GIP receptor knockout mice
2019) In Peptides(
- Contribution to journal › Scientific review
-
Mark
Incretin-based medications (GLP-1 receptor agonists, DPP-4 inhibitors) as a means to avoid hypoglycaemic episodes
(
- Contribution to journal › Article
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Mark
DPP-4 inhibition and the path to clinical proof
(
- Contribution to journal › Article
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Mark
Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects.
(
- Contribution to journal › Article
-
Mark
Effect of liraglutide on anthropometric measurements, sagittal abdominal diameter and adiponectin levels in people with type 2 diabetes treated with multiple daily insulin injections: evaluations from a randomized trial (MDI-liraglutide study 5).
(
- Contribution to journal › Article
-
Mark
Reductioninglycatedhemoglobin and daily insulin dose alongside circadian clock upregulation in patients with type 2 diabetes consuming a three-meal diet : A randomized clinical trial
(
- Contribution to journal › Article
- 2018
-
Mark
Variables associated with HbA1c and weight reductions when adding liraglutide to multiple daily insulin injections in persons with type 2 diabetes (MDI Liraglutide trial 3)
(
- Contribution to journal › Article
-
Mark
Different glucagon effects during DPP-4 inhibition versus SGLT-2 inhibition in metformin-treated type 2 diabetes patients
(
- Contribution to journal › Article
-
Mark
DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes
(
- Contribution to journal › Article
-
Mark
Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials
(
- Contribution to journal › Article
-
Mark
Effects on the glucagon response to hypoglycaemia during DPP-4 inhibition in elderly subjects with type 2 diabetes : A randomized, placebo-controlled study
(
- Contribution to journal › Article
-
Mark
Increased insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors
2018) In American Journal of Physiology - Regulatory Integrative and Comparative Physiology 314(5). p.639-646(
- Contribution to journal › Article
-
Mark
Effect of single-dose DPP-4 inhibitor sitagliptin on β-cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug-naïve, well-controlled type 2 diabetes subjects
(
- Contribution to journal › Article
- 2017
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Mark
Glucagon increases insulin levels by stimulating insulin secretion without effect on insulin clearance in mice
(
- Contribution to journal › Article
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Mark
Diurnal glucose exposure profiles of patients treated with lixisenatide before breakfast or the main meal of the day : An analysis using continuous glucose monitoring
(
- Contribution to journal › Article
-
Mark
Albiglutide for the treatment of type 2 diabetes mellitus : An integrated safety analysis of the HARMONY phase 3 trials
(
- Contribution to journal › Article
-
Mark
Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes : A randomized, open-label, 2-arm parallel comparative, exploratory trial
(
- Contribution to journal › Article
-
Mark
Once weekly glucagon-like peptide-1 receptor agonist albiglutide vs. prandial insulin added to basal insulin in patients with type 2 diabetes mellitus : Results over 52 weeks
(
- Contribution to journal › Article
-
Mark
Three-year data from 5 HARMONY phase 3 clinical trials of albiglutide in type 2 diabetes mellitus : Long-term efficacy with or without rescue therapy
(
- Contribution to journal › Article
-
Mark
Glucagon-like peptide-1 and glucose-dependent insulinotropic peptide : effects alone and in combination on insulin secretion and glucose disappearance in mice
(
- Contribution to journal › Article
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Mark
Influences of breakfast on clock gene expression and postprandial glycemia in healthy individuals and individuals with diabetes : A randomized clinical trial
(
- Contribution to journal › Article
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Mark
The vildagliptin experience - 25 years since the initiation of the novartis glucagon-like peptide-1 based therapy programme and 10 years since the first vildagliptin registration
(
- Contribution to journal › Article
-
Mark
High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA1C in Type 2 diabetes
(
- Contribution to journal › Article
-
Mark
Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2) : a 56-week, double-blind, phase 3a, randomised trial
(
- Contribution to journal › Article
-
Mark
Alain Ktorza, PhD
(
- Contribution to journal › Debate/Note/Editorial
- 2016
-
Mark
Decreased insulin secretion and glucose clearance in exocrine pancreas-insufficient pigs.
(
- Contribution to journal › Article
-
Mark
Mixed meal diminishes glucose excursion compared to glucose by several adaptive mechanisms in man.
(
- Contribution to journal › Article
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Mark
Efficacy and Cardiovascular Safety of Linagliptin as an Add-On to Insulin in Type 2 Diabetes: A Pooled Comprehensive Post Hoc Analysis.
(
- Contribution to journal › Article
-
Mark
Effect of the GLP-1 Receptor Agonist Lixisenatide on Counter-Regulatory Responses to Hypoglycemia in Subjects With Insulin-Treated Type 2 Diabetes.
(
- Contribution to journal › Article
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Mark
Enhanced Insulin Sensitivity by Adipose Tissue Browning Alters Islet Morphology and Hormone Secretion in Response to Autonomic Nervous Activation in Female Mice.
(
- Contribution to journal › Article
-
Mark
Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism.
2016) In Diabetologia(
- Contribution to journal › Article
-
Mark
Defective insulin secretion by chronic glucagon receptor activation in glucose intolerant mice.
(
- Contribution to journal › Article
-
Mark
Evidence for time dependent variation of glucagon secretion in mice.
(
- Contribution to journal › Article
-
Mark
Efficacy of lixisenatide in patients with type 2 diabetes : A post hoc analysis of patients with diverse β-cell function in the GetGoal-M and GetGoal-S trials
(
- Contribution to journal › Article
-
Mark
Estimation of the Relative Contribution of Postprandial Glucose Exposure to Average Total Glucose Exposure in Subjects with Type 2 Diabetes
(
- Contribution to journal › Article
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Mark
CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
(
- Contribution to journal › Article
-
Mark
Efficacy and safety of liraglutide added to capped insulin treatment in subjects with type 1 diabetes : The adjunct two randomized trial
(
- Contribution to journal › Article
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Mark
Insulin resistance is accompanied by increased fasting glucagon and delayed glucagon suppression in individuals with normal and impaired glucose regulation
(
- Contribution to journal › Article
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Mark
Postprandial Glucagon Reductions Correlate to Reductions in Postprandial Glucose and Glycated Hemoglobin with Lixisenatide Treatment in Type 2 Diabetes Mellitus : A Post Hoc Analysis
(
- Contribution to journal › Article
-
Mark
Extrapancreatic contribution to glucose regulation by dipeptidyl peptidase 4 inhibition
(
- Contribution to journal › Scientific review
-
Mark
Evidence for neural contribution to islet effects of DPP-4 inhibition in mice
(
- Contribution to journal › Article
-
Mark
Incretin hormone receptors are required for normal beta cell development and function in female mice
(
- Contribution to journal › Article
- 2015
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Mark
Four-Year Durability of Initial Combination Therapy with Sitagliptin and Metformin in Patients with Type 2 Diabetes in Clinical Practice; COSMIC Study.
(
- Contribution to journal › Article
-
Mark
Liraglutide in people treated for type 2 diabetes with multiple daily insulin injections: randomised clinical trial (MDI Liraglutide trial).
(
- Contribution to journal › Article
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Mark
Deciphering the hypoglycemic glucagon response: development of a graded hyperinsulinemic hypoglycemic clamp technique in female mice.
(
- Contribution to journal › Article
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Mark
Creative use of novel glucose-lowering drugs for type 2 diabetes: where will we head in the next 50 years?
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Incretin and islet hormone responses to meals of increasing size in healthy subjects.
(
- Contribution to journal › Article
-
Mark
Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin.
(
- Contribution to journal › Article
-
Mark
The Islet and Metabolism Keep Time
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice.
(
- Contribution to journal › Article
-
Mark
Fibroblast growth factor 21 prevents glycemic deterioration in insulin deficient mouse models of diabetes.
(
- Contribution to journal › Article
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Mark
Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis. Are there not some surrogate indexes lost in this story? Reply to Bastard JP, Rabasa-Lhoret R, Laville M and Disse E [letter]
(
- Contribution to journal › Letter
-
Mark
DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP-glucagon counterregulatory axis in mice.
(
- Contribution to journal › Article
-
Mark
Glucagon-early breakthroughs and recent discoveries.
(
- Contribution to journal › Scientific review
-
Mark
High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: a randomised clinical trial
(
- Contribution to journal › Article
-
Mark
Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control.
(
- Contribution to journal › Article
-
Mark
Hepato-Incretin Function of GLP-1: Novel Concept and Target in Type 1 Diabetes.
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Fasting Until Noon Triggers Increased Postprandial Hyperglycemia and Impaired Insulin Response After Lunch and Dinner in Individuals With Type 2 Diabetes: A Randomized Clinical Trial.
(
- Contribution to journal › Article
-
Mark
Incretin Effect after Oral Amino Acid Ingestion in Humans.
(
- Contribution to journal › Article
- 2014
-
Mark
Higher Risk of Hypoglycemia with Glimepiride Versus Vildagliptin in Patients with Type 2 Diabetes is not Driven by High Doses of Glimepiride: Divergent Patient Susceptibilities?
2014) In Diabetes therapy : research, treatment and education of diabetes and related disorders(
- Contribution to journal › Article
-
Mark
Impact of glucose dosing regimens on modeling of glucose tolerance and β-cell function by intravenous glucose tolerance test in diet-induced obese mice.
(
- Contribution to journal › Article
-
Mark
Conditional glucagon receptor overexpression has multi-faceted consequences for beta-cell function.
(
- Contribution to journal › Article
-
Mark
Fibroblast Growth Factor 21 (FGF21) and Glucagon Like-Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor Deficient Mice.
(
- Contribution to journal › Article
-
Mark
Efficacy of vildagliptin versus sulfonylureas as add-on therapy to metformin: comparison of results from randomised controlled and observational studies.
(
- Contribution to journal › Article
-
Mark
Equal improvement in glycaemia with lixisenatide given before breakfast or the main meal of the day.
(
- Contribution to journal › Article
-
Mark
Glucagon dynamics during hypoglycaemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes.
(
- Contribution to journal › Article
-
Mark
GLP-1 released to the mesenteric lymph duct in mice: Effects of glucose and fat.
(
- Contribution to journal › Article
-
Mark
The mind and the belly: a glance at how the nervous system directs metabolism
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial
(
- Contribution to journal › Article
-
Mark
Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets.
(
- Contribution to journal › Article
-
Mark
The neuro-incretin concept.
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis
(
- Contribution to journal › Article
-
Mark
Pronounced Reduction Of Postprandial Glucagon By Lixisenatide: A Meta-Analysis Of Randomized Clinical Trials.
(
- Contribution to journal › Article
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Mark
HARMONY 3: 104-Week Randomized, Double-Blind, Placebo- and Active-Controlled Trial Assessing the Efficacy and Safety of Albiglutide Compared With Placebo, Sitagliptin, and Glimepiride in Patients With Type 2 Diabetes Taking Metformin.
(
- Contribution to journal › Article
-
Mark
Pleiotropic Mechanisms for the Glucose-Lowering Action of DPP-4 Inhibitors.
(
- Contribution to journal › Article
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Mark
Advancing Basal Insulin Replacement in Type 2 Diabetes Inadequately Controlled With Insulin Glargine Plus Oral Agents: A Comparison of Adding Albiglutide, a Weekly GLP-1 Receptor Agonist, Versus Thrice-Daily Prandial Insulin Lispro.
(
- Contribution to journal › Article
-
Mark
Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.
(
- Contribution to journal › Article
-
Mark
Glucagon clearance is regulated by nutritional state : Evidence from experimental studies in mice
(
- Contribution to journal › Article
-
Mark
Insulin plus incretin: A glucose-lowering strategy for type 2-diabetes.
(
- Contribution to journal › Scientific review
- 2013
-
Mark
Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion.
(
- Contribution to journal › Article
-
Mark
Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease
(
- Contribution to journal › Article
-
Mark
Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials
(
- Contribution to journal › Article
-
Mark
Incretin dysfunction in type 2 diabetes: Clinical impact and future perspectives.
(
- Contribution to journal › Scientific review
-
Mark
Sitagliptin and pioglitazone provide complementary effects on postprandial glucose and pancreatic islet cell function
(
- Contribution to journal › Article
-
Mark
Glucose-lowering effect of the DPP-4 inhibitor sitagliptin after glucose and non-glucose macronutrient ingestion in non-diabetic subjects.
(
- Contribution to journal › Article
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Mark
Efficacy and Safety of Lixisenatide Once-Daily Morning or Evening Injections in Type 2 Diabetes Inadequately Controlled on Metformin (GetGoal-M).
(
- Contribution to journal › Article
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Mark
Shifting the paradigm of islet inflammation-good guy or bad guy?
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Methods and Models for Metabolic Assessment in Mice
2013) In Journal of Diabetes Research(
- Contribution to journal › Article
-
Mark
Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model.
(
- Contribution to journal › Article
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Mark
Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes.
(
- Contribution to journal › Article
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Mark
Serum but not Cerebrospinal Fluid levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 (IGFBP-3) are Increased in Alzheimer ́s Disease
2013) Endokrindagarna, 2013(
- Contribution to conference › Poster
- 2012
-
Mark
Vildagliptin Reduces Glucagon during Hyperglycemia and Sustains Glucagon Counterregulation during Hypoglycemia in Type 1 Diabetes.
(
- Contribution to journal › Article
-
Mark
Differential Development of Glucose Intolerance and Pancreatic Islet Adaptation in Multiple Diet Induced Obesity Models
(
- Contribution to journal › Article
-
Mark
Varning för okritisk användning av överviktskirurgi vid typ 2-diabetes.
(
- Contribution to journal › Article
-
Mark
Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice.
(
- Contribution to journal › Article
-
Mark
DPP-4 inhibition and islet function
(
- Contribution to journal › Scientific review
-
Mark
Plasma lipid fatty acid composition, desaturase activities and insulin sensitivity in Amerindian women
(
- Contribution to journal › Article
-
Mark
Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis.
(
- Contribution to journal › Article
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Mark
The hyperstimulated beta-cell: prelude to diabetes?
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Switching From High-Fat to Low-Fat Diet Normalizes Glucose Metabolism and Improves Glucose-Stimulated Insulin Secretion and Insulin Sensitivity But Not Body Weight in C57BL/6J Mice.
(
- Contribution to journal › Article
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Mark
Using albumin to improve the therapeutic properties of diabetes treatments.
(
- Contribution to journal › Article
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Mark
Islet nerves in focus-defining their neurobiological and clinical role.
2012) In Diabetologia(
- Contribution to journal › Article
-
Mark
Incretin hormones and the up-regulation of insulin secretion in insulin resistance.
(
- Contribution to journal › Article
- 2011
-
Mark
Increased IL-1 beta reactivity upon a glucose challenge in patients with deliberate self-harm
(
- Contribution to journal › Article
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Mark
Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice
2011) In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 300(5). p.1126-1133(
- Contribution to journal › Article
-
Mark
The dynamic incretin adaptation and type 2 diabetes.
(
- Contribution to journal › Article
-
Mark
Editorial: Long in the shade, glucagon re-occupies centre court
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice.
(
- Contribution to journal › Article
-
Mark
Positive correlation between tumor necrosis factor (TNF)-alpha and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women
(
- Contribution to journal › Article
-
Mark
Mechanisms of Action of the DPP-4 Inhibitor Vildagliptin in Man.
(
- Contribution to journal › Scientific review
-
Mark
Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase 4 activity in obese patients with type 2 diabetes.
(
- Contribution to journal › Article
-
Mark
GLP-1 for type 2 diabetes
(
- Contribution to journal › Scientific review
-
Mark
Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin.
(
- Contribution to journal › Article
-
Mark
The future of incretin-based therapy: novel avenues-novel targets.
(
- Contribution to journal › Article
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Mark
Incretin Hormone and Insulin Responses to Oral Versus Intravenous Lipid Administration in Humans.
(
- Contribution to journal › Article
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Mark
Are Sulfonylureas Less Desirable Than DPP-4 Inhibitors as Add-on to Metformin in the Treatment of Type 2 Diabetes?
(
- Contribution to journal › Article
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Mark
Reply to the letter by P. Guillausseau Regarding "Sulfonylureas or Dipeptidyl Peptidase (DPP-4) Inhibitors in the Management of Type 2 Diabetes: Debate Is Not Yet Closed"
(
- Contribution to journal › Article
-
Mark
Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.
(
- Contribution to journal › Article
- 2010
-
Mark
A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease.
(
- Contribution to journal › Article
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Mark
Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet
(
- Contribution to journal › Article
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Mark
Changes in Prandial Glucagon Levels after 2-year Treatment with Vildagliptin or Glimepiride in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin Monotherapy.
(
- Contribution to journal › Article
-
Mark
Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice
(
- Contribution to journal › Article
-
Mark
Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo
(
- Contribution to journal › Article
-
Mark
Disassociated relation between plasma tumor necrosis factor-alpha, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance
(
- Contribution to journal › Article
-
Mark
What ails the beta-cell?
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
CART is upregulated in islets of type 2 diabetic patients, stimulates insulin secretion, inhibits glucagon secretion and protects against beta cell death
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.95-95(
- Contribution to journal › Published meeting abstract
-
Mark
Increased beta-cell volume in mice fed a high-fat diet A dynamic study over 12 months
(
- Contribution to journal › Article
-
Mark
Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice.
(
- Contribution to journal › Article
-
Mark
Glucagon normalises disposition index by increasing acute insulin response to intravenous glucose: comparison with incretins
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.694-694(
- Contribution to journal › Published meeting abstract
-
Mark
Degradation of GIP but not of GLP-1 is reduced after protein ingestion in obese subjects
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.646-646(
- Contribution to journal › Published meeting abstract
-
Mark
Cerebrospinal fluid insulin during non-neurological surgery
(
- Contribution to journal › Article
-
Mark
Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study
(
- Contribution to journal › Article
-
Mark
Pituitary adenylate cyclase-activating polypeptide (PACAP) and islet function
(
- Contribution to journal › Published meeting abstract
-
Mark
Cocaine- and amphetamine-regulated transcript (CART) is upregulated in islets of type-2 diabetic patients to stimulate insulin secretion, inhibit glucagon secretion and protect against beta cell death
(
- Contribution to journal › Published meeting abstract
-
Mark
The incretin effect is apparent after lipid challenge in healthy humans
2010) 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) In Diabetologia 53(Suppl. 1). p.648-648(
- Contribution to journal › Published meeting abstract
-
Mark
Changes in cerebrospinal fluid insulin during non-neurological surgery
2010) 23rd Congress Meeting of European-College-of-Neuropsychopharmacology In European Neuropsychopharmacology 20. p.328-329(
- Contribution to journal › Published meeting abstract
-
Mark
Increased β-cell volume in mice fed a high-fat diet: A dynamic study over 12 months.
(
- Contribution to journal › Article
-
Mark
Incretin hormone secretion over the day.
(
- Contribution to journal › Article
-
Mark
Eget ansvar i vården?
Sahlin, Nils-Eric LU ; Ahrén, Bo LU and Ståhl, Katrin LU (2010)
- Book/Report › Anthology (editor)
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Secretion and Dipeptidyl Peptidase-4-Mediated Metabolism of Incretin Hormones after a Mixed Meal or Glucose Ingestion in Obese Compared to Lean, Nondiabetic Men.
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- Contribution to journal › Article
- 2009
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Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
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- Contribution to journal › Article
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Differential reduction in incretin hormone response to different macronutrients in obese vs lean healthy subjects
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.568-568(
- Contribution to journal › Published meeting abstract
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Differential Islet and Incretin Hormone Responses in Morning vs. Afternoon after Standardized Meal in Healthy Men.
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- Contribution to journal › Article
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Arterial Gastroduodenal Infusion of Cholecystokinin-33 Stimulates the Exocrine Pancreatic Enzyme Release Via an Enteropancreatic Reflex, Without Affecting the Endocrine Insulin Secretion in Pigs.
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- Contribution to journal › Article
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Changes in prandial glucagon levels after 2 years treatment with vildagliptin or glimepiride
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.798-798(
- Contribution to journal › Published meeting abstract
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beta-Cell research - A decade of rapid growth
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- Contribution to journal › Article
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Changes in cerebrospinal fluid insulin during non-neurological surgery
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.677-677(
- Contribution to journal › Published meeting abstract
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Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes.
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- Contribution to journal › Scientific review
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Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery
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- Contribution to journal › Article
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Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice
2009) In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 296(5). p.1316-1324(
- Contribution to journal › Article
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Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid
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- Contribution to journal › Article
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Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin - diabetes control and potential adverse events
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- Contribution to journal › Article
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GIP and GLP-1 normalize glucose tolerance by normalizing islet adaptation to insulin resistance without increasing glucose effectiveness in high-fat fed mice
2009) 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes In Diabetologia 52(Suppl 1). p.197-197(
- Contribution to journal › Published meeting abstract
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Vildagliptin improves glucose sensitivity of cells in patients with type 2 diabetes: glucagon response to hypoglycemia
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- Contribution to journal › Published meeting abstract
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Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets.
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- Contribution to journal › Article
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Altered glucose tolerance in women with deliberate self-harm.
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Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.
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- Contribution to journal › Article
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Vildagliptin Enhances Islet Responsiveness to Both Hyper- and Hypoglycemia in Patients with Type 2 Diabetes.
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- Contribution to journal › Article
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Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study
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- Contribution to journal › Article
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beta- and alpha-Cell Dysfunction in Subjects Developing Impaired Glucose Tolerance Outcome of a 12-Year Prospective Study in Postmenopausal Caucasian Women
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- Contribution to journal › Article
- 2008
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Vildagliptin improves alpha cell glucose sensing in patients with type 2 diabetes
2008) 44th EASD Annual Meeting of the European Association for the Study of Diabetes In Diabetologia 51(S1). p.36-37(
- Contribution to journal › Published meeting abstract
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Diurnal variation in the incretin response to a meal challenge in humans
2008) 44th EASD Annual Meeting of the European Association for the Study of Diabetes In Diabetologia 51(S1). p.247-247(
- Contribution to journal › Published meeting abstract
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Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin
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- Contribution to journal › Article
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Sex-related differences in the associations between hyperleptinemia, insulin resistance and dysfibrinolysis
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Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus
2008) In Experimental Diabetes Research(
- Contribution to journal › Article
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Reconstructing the pancreas: Restoration of normoglycemia, exocrine function, and islet innervation by islet transplantation to the pancreas
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Incretin and islet hormonal responses to fat and protein ingestion in healthy men
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Role of pituitary adenylate cyclase-activating polypeptide in the pancreatic endocrine system.
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Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin.
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Disturbed alpha-cell function in mice with beta-cell specific overexpression of human islet amyloid polypeptide.
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The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice.
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Evidence that autonomic mechanisms contribute to the adaptive increase in insulin secretion during dexamethasone-induced insulin resistance in humans.
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Body fat related to daily physical activity and insulin concentrations in non-diabetic children.
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Durable islet effects on insulin secretion and protein kinase A expression following exendin-4 treatment of high-fat diet-fed mice.
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The islet enhancer vildagliptin: mechanisms of improved glucose metabolism.
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Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes.
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Clinical measures of islet function: usefulness to characterize defects in diabetes.
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- Contribution to journal › Article
- 2007
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Role of VIP and PACAP in islet function
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Improved metabolic risk markers following two 6-month physical activity programs among socioeconomic marginalized women of native American ancestry in Lima, Peru
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Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes
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Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects.
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The impact of large tidal volume ventilation on the absorption of inhaled insulin in rabbits.
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G-protein-coupled receptors and islet function-Implications for treatment of type 2 diabetes.
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A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.
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DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.
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Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.
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Gender-specific links between hepatic 11 beta reduction of cortisone and adipokines
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Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice.
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DPP-4 Inhibitors -- Clinical Data and Clinical Implications.
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- Contribution to journal › Scientific review
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Omega-3 fatty acids and other PUFAs and weight control
2007)(
- Chapter in Book/Report/Conference proceeding › Book chapter
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GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors.
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- Contribution to journal › Article
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Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice
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- Contribution to journal › Article
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DPP-4 inhibitors.
2007) In Baillière's Best Practice & Research in Clinical Endocrinology & Metabolism 21(4). p.517-533(
- Contribution to journal › Article
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Två genombrott i behandling av typ 2-diabetes. Både receptoragonist och enzymhämmare har nu nått kliniken.
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- Contribution to journal › Article
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Improved meal-related insulin processing contributes to the enhancement of B-Cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes
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- Contribution to journal › Article
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GPR40 is expressed in glucagon producing cells and affects glucagon secretion.
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- Contribution to journal › Article
- 2006
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Binding and the effect of the red kidney bean lectin, phytohaemagglutinin, in the gastrointestinal tract of suckling rats
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- Contribution to journal › Article
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Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice.
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- Contribution to journal › Article
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Glucagon secretion in relation to insulin sensitivity in healthy subjects.
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- Contribution to journal › Article
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Postprandial interstitial insulin concentrations in type 2 diabetes relatives
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Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.
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- Contribution to journal › Article
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Contributions from the first SICOD meeting (Stockholm, October 2004)
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- Contribution to journal › Debate/Note/Editorial
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Adrenal incidentaloma - follow-up results from a Swedish prospective study
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- Contribution to journal › Article
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Glucose-stimulated insulin secretion correlates with beta-cell lipolysis.
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- Contribution to journal › Article
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Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties.
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- Contribution to journal › Article
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The insulin response to gastric glucose is reduced in PAC1 and GRP receptor gene deleted mice.
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- Contribution to journal › Article
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Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver
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- Contribution to journal › Article
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Leptin is closely related to body fat in prepubertal children aged 8-11 years.
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- Contribution to journal › Article
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A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.
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- Contribution to journal › Article
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Neuropeptides and the regulation of islet function.
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Mature-onset obesity in interleukin-1 receptor I knockout mice
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- Contribution to journal › Article
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Serum cholesteryl fatty acid composition and plasma glucose concentrations in Amerindian women.
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- Contribution to journal › Article
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{beta}-Cell Lipases and Insulin Secretion.
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A Novel Approach to Assess Insulin Sensitivity Reveals No Increased Insulin Sensitivity in Mice with a Dominant-Negative Mutant Hepatocyte Nuclear Factor-1{alpha}
2006) In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 291(1). p.131-137(
- Contribution to journal › Article
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Suppression of apolipoprotein M expression and secretion in alloxan-diabetic mouse: Partial reversal by insulin.
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Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function
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Klinisk forskning måste baseras på team av både kliniker och forskare
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- Contribution to journal › Letter
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Down-regulation of apolipoprotein M expression is mediated by phosphatidylinositol 3-kinase in HepG2 cells.
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- Contribution to journal › Article
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Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice.
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- Contribution to journal › Article
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In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse - Pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells
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- Contribution to journal › Article
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Improvement in cardiac systolic function and reduced prevalence of metabolic syndrome after 2 years of GH treatment in GH deficient adult survivors of childhood acute lymphoblastic leukaemia.
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- Contribution to journal › Article
- 2005
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The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice.
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Reduced insulin clearance contributes to the increased insulin levels after administration of glucagon-like peptide 1 in mice.
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- Contribution to journal › Article
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Beta-cell expression of a dominant-negative HNF-1alpha compromises the ability of inhibition of dipeptidyl peptidase-4 to elicit a long-term augmentation of insulin secretion in mice.
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- Contribution to journal › Article
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Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males
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- Contribution to journal › Article
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Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker diabetic fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV
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- Contribution to journal › Article
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Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats
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- Contribution to journal › Article
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Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice
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- Contribution to journal › Article